Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990452086> ?p ?o ?g. }
- W1990452086 endingPage "21" @default.
- W1990452086 startingPage "14" @default.
- W1990452086 abstract "Arsenic is a well-documented human carcinogen and is known to cause oxidative stress in cultured cells and animals. A hospital-based case-control study was conducted to evaluate the relationship among the levels of urinary 8-hydroxydeoxyguanosine (8-OHdG), the arsenic profile, and urothelial carcinoma (UC). Urinary 8-OHdG was measured by using high-sensitivity enzyme-linked immunosorbent assay (ELISA) kits. The urinary species of inorganic arsenic and their metabolites were analyzed by high-performance liquid chromatography (HPLC) and hydride generator-atomic absorption spectrometry (HG-AAS). This study showed that the mean urinary concentration of total arsenics was significantly higher, at 37.67+/-2.98 microg/g creatinine, for UC patients than for healthy controls of 21.10+/-0.79 microg/g creatinine (p<0.01). Urinary 8-OHdG levels correlated with urinary total arsenic concentrations (r=0.19, p<0.01). There were significantly higher 8-OHdG levels, of 7.48+/-0.97 ng/mg creatinine in UC patients, compared to healthy controls of 5.95+/-0.21 ng/mg creatinine. Furthermore, female UC patients had higher 8-OHdG levels of 9.22+/-0.75 than those of males at 5.76+/-0.25 ng/mg creatinine (p<0.01). Multiple linear regression analyses revealed that high urinary 8-OHdG levels were associated with increased total arsenic concentrations, inorganic arsenite, monomethylarsonic acid (MMA), and dimethylarsenate (DMA) as well as the primary methylation index (PMI) even after adjusting for age, gender, and UC status. The results suggest that oxidative DNA damage was associated with arsenic exposure, even at low urinary level of arsenic." @default.
- W1990452086 created "2016-06-24" @default.
- W1990452086 creator A5030951075 @default.
- W1990452086 creator A5055953293 @default.
- W1990452086 creator A5073853082 @default.
- W1990452086 creator A5077644656 @default.
- W1990452086 creator A5079509862 @default.
- W1990452086 creator A5084589126 @default.
- W1990452086 creator A5085342962 @default.
- W1990452086 date "2008-01-01" @default.
- W1990452086 modified "2023-10-14" @default.
- W1990452086 title "Urinary 8-hydroxydeoxyguanosine and urothelial carcinoma risk in low arsenic exposure area" @default.
- W1990452086 cites W1505133202 @default.
- W1990452086 cites W1517590819 @default.
- W1990452086 cites W1891879236 @default.
- W1990452086 cites W1966398962 @default.
- W1990452086 cites W1977318871 @default.
- W1990452086 cites W1984255063 @default.
- W1990452086 cites W2002721333 @default.
- W1990452086 cites W2004386304 @default.
- W1990452086 cites W2008026863 @default.
- W1990452086 cites W2017809988 @default.
- W1990452086 cites W2019455369 @default.
- W1990452086 cites W2021346010 @default.
- W1990452086 cites W2030117536 @default.
- W1990452086 cites W2037410441 @default.
- W1990452086 cites W2039029820 @default.
- W1990452086 cites W2040474332 @default.
- W1990452086 cites W2043671866 @default.
- W1990452086 cites W2046155936 @default.
- W1990452086 cites W2048468348 @default.
- W1990452086 cites W2048553024 @default.
- W1990452086 cites W2049257272 @default.
- W1990452086 cites W2053485263 @default.
- W1990452086 cites W2053798667 @default.
- W1990452086 cites W2055388350 @default.
- W1990452086 cites W2058491607 @default.
- W1990452086 cites W2059949476 @default.
- W1990452086 cites W2072008845 @default.
- W1990452086 cites W2078965860 @default.
- W1990452086 cites W2090975426 @default.
- W1990452086 cites W2096860860 @default.
- W1990452086 cites W2102311939 @default.
- W1990452086 cites W2105360146 @default.
- W1990452086 cites W2108082718 @default.
- W1990452086 cites W2109454629 @default.
- W1990452086 cites W2109543726 @default.
- W1990452086 cites W2110244716 @default.
- W1990452086 cites W2111671637 @default.
- W1990452086 cites W2112815302 @default.
- W1990452086 cites W2114344561 @default.
- W1990452086 cites W2124121379 @default.
- W1990452086 cites W2127185984 @default.
- W1990452086 cites W2129774057 @default.
- W1990452086 cites W2137052778 @default.
- W1990452086 cites W2140121626 @default.
- W1990452086 cites W2148733641 @default.
- W1990452086 cites W2155081928 @default.
- W1990452086 cites W2529100617 @default.
- W1990452086 doi "https://doi.org/10.1016/j.taap.2007.08.021" @default.
- W1990452086 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17950770" @default.
- W1990452086 hasPublicationYear "2008" @default.
- W1990452086 type Work @default.
- W1990452086 sameAs 1990452086 @default.
- W1990452086 citedByCount "70" @default.
- W1990452086 countsByYear W19904520862012 @default.
- W1990452086 countsByYear W19904520862013 @default.
- W1990452086 countsByYear W19904520862014 @default.
- W1990452086 countsByYear W19904520862015 @default.
- W1990452086 countsByYear W19904520862016 @default.
- W1990452086 countsByYear W19904520862017 @default.
- W1990452086 countsByYear W19904520862018 @default.
- W1990452086 countsByYear W19904520862019 @default.
- W1990452086 countsByYear W19904520862020 @default.
- W1990452086 countsByYear W19904520862021 @default.
- W1990452086 countsByYear W19904520862022 @default.
- W1990452086 countsByYear W19904520862023 @default.
- W1990452086 crossrefType "journal-article" @default.
- W1990452086 hasAuthorship W1990452086A5030951075 @default.
- W1990452086 hasAuthorship W1990452086A5055953293 @default.
- W1990452086 hasAuthorship W1990452086A5073853082 @default.
- W1990452086 hasAuthorship W1990452086A5077644656 @default.
- W1990452086 hasAuthorship W1990452086A5079509862 @default.
- W1990452086 hasAuthorship W1990452086A5084589126 @default.
- W1990452086 hasAuthorship W1990452086A5085342962 @default.
- W1990452086 hasConcept C126322002 @default.
- W1990452086 hasConcept C126894567 @default.
- W1990452086 hasConcept C134018914 @default.
- W1990452086 hasConcept C178790620 @default.
- W1990452086 hasConcept C185592680 @default.
- W1990452086 hasConcept C2776305511 @default.
- W1990452086 hasConcept C2780026642 @default.
- W1990452086 hasConcept C2780306776 @default.
- W1990452086 hasConcept C502230775 @default.
- W1990452086 hasConcept C55493867 @default.
- W1990452086 hasConcept C71924100 @default.
- W1990452086 hasConcept C77411442 @default.
- W1990452086 hasConceptScore W1990452086C126322002 @default.