FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990455141> ?p ?o ?g. }

• W1990455141 endingPage "1013" @default.
• W1990455141 startingPage "1005" @default.
• W1990455141 abstract "Background Antiretrovirals that achieve adequate concentrations in anatomical sites of transmission are of interest for HIV prevention. A Phase I open-label pharmacokinetic (PK) study was performed to describe first dose (PK1) and steady-state (PK2) PKs of the integrase inhibitor dolutegravir (DTG) in blood plasma (BP), cervicovaginal fluid (CVF), cervical tissue (CT) and vaginal tissue (VT) in HIV type-1-negative women. Methods A total of 8 healthy females given DTG 50 mg daily for 5–7 days had 11 paired BP and CVF samples collected over 24 h following the first dose (PK1) and multiple dosing (PK2). Each woman underwent CT and VT biopsies at 1/4 time points at PK1 and PK2 to generate composite PK profiles. DTG concentrations were analysed by validated liquid chromatography-tandem mass spectrometry methods. Non-compartmental PK analysis was performed and Spearman rank correlations determined between matrices. Results BP areas under the concentration–time curve (AUCs) were similar to previous reports and concentrations remained greater than the protein-adjusted (PA) 90% inhibitory concentration (IC 90 ) for wild-type HIV (64 ng/ml). CVF exposures were approximately 6% of BP with low inter-individual variability. CT and VT exposures were 7% of BP at PK1, and 9–10% of BP at PK2 with 94% of samples >PA-IC 90 . CT and VT concentrations were correlated to each other (ρ=0.70, P=0.003), and to CVF at steady state (ρ=0.52, P=0.04). Accumulation of DTG from PK1 to PK2 occurred in BP, CT and VT, but only marginally in CVF. Conclusions DTG BP PK were consistent with previously published values. CVF, CT and VT exposures were highly correlated. At PK2, DTG accumulated to a greater extent in tissue than in BP or CVF, suggesting increased tissue affinity." @default.
• W1990455141 created "2016-06-24" @default.
• W1990455141 creator A5000561788 @default.
• W1990455141 creator A5021388560 @default.
• W1990455141 creator A5034242048 @default.
• W1990455141 creator A5034376098 @default.
• W1990455141 creator A5038196837 @default.
• W1990455141 creator A5044604990 @default.
• W1990455141 creator A5083242464 @default.
• W1990455141 date "2013-11-01" @default.
• W1990455141 modified "2023-09-25" @default.
• W1990455141 title "Single and Multiple Dose Pharmacokinetics of Dolutegravir in the Genital Tract of HIV-Negative Women" @default.
• W1990455141 cites W1990069515 @default.
• W1990455141 cites W1993270674 @default.
• W1990455141 cites W2014673451 @default.
• W1990455141 cites W2015256169 @default.
• W1990455141 cites W2050494263 @default.
• W1990455141 cites W2059016715 @default.
• W1990455141 cites W2095721785 @default.
• W1990455141 cites W2098185748 @default.
• W1990455141 cites W2100430786 @default.
• W1990455141 cites W2106130482 @default.
• W1990455141 cites W2116165373 @default.
• W1990455141 cites W2117057469 @default.
• W1990455141 cites W2122026430 @default.
• W1990455141 cites W2139430929 @default.
• W1990455141 cites W2152505869 @default.
• W1990455141 cites W2155792409 @default.
• W1990455141 cites W2162226934 @default.
• W1990455141 cites W2168251450 @default.
• W1990455141 doi "https://doi.org/10.3851/imp2665" @default.
• W1990455141 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4038682" @default.
• W1990455141 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23899439" @default.
• W1990455141 hasPublicationYear "2013" @default.
• W1990455141 type Work @default.
• W1990455141 sameAs 1990455141 @default.
• W1990455141 citedByCount "33" @default.
• W1990455141 countsByYear W19904551412014 @default.
• W1990455141 countsByYear W19904551412015 @default.
• W1990455141 countsByYear W19904551412016 @default.
• W1990455141 countsByYear W19904551412017 @default.
• W1990455141 countsByYear W19904551412018 @default.
• W1990455141 countsByYear W19904551412019 @default.
• W1990455141 countsByYear W19904551412021 @default.
• W1990455141 countsByYear W19904551412022 @default.
• W1990455141 countsByYear W19904551412023 @default.
• W1990455141 crossrefType "journal-article" @default.
• W1990455141 hasAuthorship W1990455141A5000561788 @default.
• W1990455141 hasAuthorship W1990455141A5021388560 @default.
• W1990455141 hasAuthorship W1990455141A5034242048 @default.
• W1990455141 hasAuthorship W1990455141A5034376098 @default.
• W1990455141 hasAuthorship W1990455141A5038196837 @default.
• W1990455141 hasAuthorship W1990455141A5044604990 @default.
• W1990455141 hasAuthorship W1990455141A5083242464 @default.
• W1990455141 hasBestOaLocation W19904551412 @default.
• W1990455141 hasConcept C112705442 @default.
• W1990455141 hasConcept C126322002 @default.
• W1990455141 hasConcept C126894567 @default.
• W1990455141 hasConcept C142462285 @default.
• W1990455141 hasConcept C159047783 @default.
• W1990455141 hasConcept C2777288759 @default.
• W1990455141 hasConcept C2779502633 @default.
• W1990455141 hasConcept C2989005 @default.
• W1990455141 hasConcept C2993143319 @default.
• W1990455141 hasConcept C3013748606 @default.
• W1990455141 hasConcept C71924100 @default.
• W1990455141 hasConcept C76318530 @default.
• W1990455141 hasConcept C90924648 @default.
• W1990455141 hasConceptScore W1990455141C112705442 @default.
• W1990455141 hasConceptScore W1990455141C126322002 @default.
• W1990455141 hasConceptScore W1990455141C126894567 @default.
• W1990455141 hasConceptScore W1990455141C142462285 @default.
• W1990455141 hasConceptScore W1990455141C159047783 @default.
• W1990455141 hasConceptScore W1990455141C2777288759 @default.
• W1990455141 hasConceptScore W1990455141C2779502633 @default.
• W1990455141 hasConceptScore W1990455141C2989005 @default.
• W1990455141 hasConceptScore W1990455141C2993143319 @default.
• W1990455141 hasConceptScore W1990455141C3013748606 @default.
• W1990455141 hasConceptScore W1990455141C71924100 @default.
• W1990455141 hasConceptScore W1990455141C76318530 @default.
• W1990455141 hasConceptScore W1990455141C90924648 @default.
• W1990455141 hasIssue "8" @default.
• W1990455141 hasLocation W19904551411 @default.
• W1990455141 hasLocation W19904551412 @default.
• W1990455141 hasLocation W19904551413 @default.
• W1990455141 hasLocation W19904551414 @default.
• W1990455141 hasLocation W19904551415 @default.
• W1990455141 hasOpenAccess W1990455141 @default.
• W1990455141 hasPrimaryLocation W19904551411 @default.
• W1990455141 hasRelatedWork W1980896309 @default.
• W1990455141 hasRelatedWork W1990069515 @default.
• W1990455141 hasRelatedWork W2002994412 @default.
• W1990455141 hasRelatedWork W2150833007 @default.
• W1990455141 hasRelatedWork W2397722179 @default.
• W1990455141 hasRelatedWork W2418914870 @default.
• W1990455141 hasRelatedWork W2899072855 @default.
• W1990455141 hasRelatedWork W2922294623 @default.
• W1990455141 hasRelatedWork W3087516196 @default.

• next