Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990455528> ?p ?o ?g. }
- W1990455528 endingPage "137" @default.
- W1990455528 startingPage "130" @default.
- W1990455528 abstract "In our previous report, we described a novel non-peptidic organic ligand of CD4 D1, designated J2, as a potential inhibitor of CD4 D1 and thus CD4-dependent T cell responses in vitro. In this work, we further used a murine model of corneal allograft rejection to determine its in vivo immunosuppressive activities. To mimic the situation in high-risk human eyes, the recipient mice corneas were all induced by intrastromal sutures to serve as neovascularized graft beds. J2 was administrated by mouth 3 h before transplantation and thereafter on consecutive 12 days. The results showed that J2 could significantly prolong the median survival time of the corneal allografts, compared to the untreated control group. And the subsequent functional assays, including T cell phenotype analysis, delayed-type hypersensitivity (DTH) and enzyme-linked immunospot (ELISPOT) assays revealed that the immunosuppressive activity of J2 was associated with its inhibitory effects on the CD4+ T cells and these cells-mediated responses. All these results suggest that J2 is a potential lead for the development of new immunosuppressive agents to prevent the corneal allograft rejection." @default.
- W1990455528 created "2016-06-24" @default.
- W1990455528 creator A5026273707 @default.
- W1990455528 creator A5027597262 @default.
- W1990455528 creator A5033224484 @default.
- W1990455528 creator A5037360770 @default.
- W1990455528 creator A5050852420 @default.
- W1990455528 creator A5060514130 @default.
- W1990455528 creator A5070265466 @default.
- W1990455528 creator A5071798264 @default.
- W1990455528 creator A5081615766 @default.
- W1990455528 date "2007-11-01" @default.
- W1990455528 modified "2023-09-23" @default.
- W1990455528 title "J2 prolongs the corneal allograft survival through inhibition of the CD4+ T cell-mediated response in vivo" @default.
- W1990455528 cites W107721504 @default.
- W1990455528 cites W1507999061 @default.
- W1990455528 cites W1534847634 @default.
- W1990455528 cites W1545865178 @default.
- W1990455528 cites W1557197750 @default.
- W1990455528 cites W1562090983 @default.
- W1990455528 cites W157068544 @default.
- W1990455528 cites W170122927 @default.
- W1990455528 cites W182635649 @default.
- W1990455528 cites W1831866534 @default.
- W1990455528 cites W1884067458 @default.
- W1990455528 cites W1975220496 @default.
- W1990455528 cites W197764648 @default.
- W1990455528 cites W1978018492 @default.
- W1990455528 cites W1988523451 @default.
- W1990455528 cites W1989400519 @default.
- W1990455528 cites W1991752750 @default.
- W1990455528 cites W1997946916 @default.
- W1990455528 cites W2001001705 @default.
- W1990455528 cites W2005007838 @default.
- W1990455528 cites W2020801013 @default.
- W1990455528 cites W2023817268 @default.
- W1990455528 cites W2025734854 @default.
- W1990455528 cites W2027002725 @default.
- W1990455528 cites W2027370944 @default.
- W1990455528 cites W2028834214 @default.
- W1990455528 cites W2031599341 @default.
- W1990455528 cites W2034146644 @default.
- W1990455528 cites W2039484891 @default.
- W1990455528 cites W2040239455 @default.
- W1990455528 cites W2041509515 @default.
- W1990455528 cites W2042630557 @default.
- W1990455528 cites W2046806013 @default.
- W1990455528 cites W2047451661 @default.
- W1990455528 cites W2056034283 @default.
- W1990455528 cites W2057580113 @default.
- W1990455528 cites W2069611925 @default.
- W1990455528 cites W207678091 @default.
- W1990455528 cites W2079355826 @default.
- W1990455528 cites W2086335318 @default.
- W1990455528 cites W2093409661 @default.
- W1990455528 cites W2099651445 @default.
- W1990455528 cites W2112645404 @default.
- W1990455528 cites W2118837076 @default.
- W1990455528 cites W2139861368 @default.
- W1990455528 cites W2140534997 @default.
- W1990455528 cites W2163242455 @default.
- W1990455528 cites W2167735713 @default.
- W1990455528 cites W2168195047 @default.
- W1990455528 cites W2169994044 @default.
- W1990455528 cites W2170656612 @default.
- W1990455528 cites W2414546618 @default.
- W1990455528 cites W273005537 @default.
- W1990455528 cites W29224037 @default.
- W1990455528 cites W81302761 @default.
- W1990455528 doi "https://doi.org/10.1016/j.trim.2007.05.013" @default.
- W1990455528 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18005857" @default.
- W1990455528 hasPublicationYear "2007" @default.
- W1990455528 type Work @default.
- W1990455528 sameAs 1990455528 @default.
- W1990455528 citedByCount "6" @default.
- W1990455528 countsByYear W19904555282013 @default.
- W1990455528 countsByYear W19904555282015 @default.
- W1990455528 countsByYear W19904555282017 @default.
- W1990455528 crossrefType "journal-article" @default.
- W1990455528 hasAuthorship W1990455528A5026273707 @default.
- W1990455528 hasAuthorship W1990455528A5027597262 @default.
- W1990455528 hasAuthorship W1990455528A5033224484 @default.
- W1990455528 hasAuthorship W1990455528A5037360770 @default.
- W1990455528 hasAuthorship W1990455528A5050852420 @default.
- W1990455528 hasAuthorship W1990455528A5060514130 @default.
- W1990455528 hasAuthorship W1990455528A5070265466 @default.
- W1990455528 hasAuthorship W1990455528A5071798264 @default.
- W1990455528 hasAuthorship W1990455528A5081615766 @default.
- W1990455528 hasConcept C141071460 @default.
- W1990455528 hasConcept C150903083 @default.
- W1990455528 hasConcept C202751555 @default.
- W1990455528 hasConcept C203014093 @default.
- W1990455528 hasConcept C207001950 @default.
- W1990455528 hasConcept C26291073 @default.
- W1990455528 hasConcept C2776090121 @default.
- W1990455528 hasConcept C2779053233 @default.
- W1990455528 hasConcept C2780686511 @default.
- W1990455528 hasConcept C2911091166 @default.