Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990455719> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1990455719 endingPage "41" @default.
- W1990455719 startingPage "32" @default.
- W1990455719 abstract "In our previous study on the prepositus hypoglossi nucleus (PHN), we found a neuronal subtype exhibiting a specific firing pattern in which the first interspike interval (ISI) was longer than that of the second, designated FIL (first interspike interval long) neurons. In the present study, we explored the ionic mechanisms underlying this firing pattern using whole-cell recordings of rat brainstem slice preparations. In addition to a longer first ISI, FIL neurons showed properties such as increased slow afterhyperpolarization (AHP) of the first spike relative to the second spike. The application of 4-aminopyridine (4-AP) shortened the longer first ISI and reduced the larger AHP of the first spike, but α-dendrotoxin affected neither the ISI nor the AHP. A voltage clamp study revealed that FIL neurons express transient outward currents with slow decay kinetics. When T-type Ca2+ currents alone or T-type Ca2+ plus persistent Na+ currents were blocked, the FIL firing pattern changed to one with transient hyperpolarization and delayed spike generation characteristic of late-spiking neurons. These findings indicate that A-type K+ currents showing slow decay, T-type Ca2+ currents, and persistent Na+ currents all contribute to the specific firing pattern of FIL neurons." @default.
- W1990455719 created "2016-06-24" @default.
- W1990455719 creator A5014321400 @default.
- W1990455719 creator A5053556602 @default.
- W1990455719 creator A5056081259 @default.
- W1990455719 date "2012-05-01" @default.
- W1990455719 modified "2023-10-04" @default.
- W1990455719 title "Characterization of ionic channels underlying the specific firing pattern of a novel neuronal subtype in the rat prepositus hypoglossi nucleus" @default.
- W1990455719 cites W1591734677 @default.
- W1990455719 cites W1923448222 @default.
- W1990455719 cites W1964017278 @default.
- W1990455719 cites W1971025489 @default.
- W1990455719 cites W1983568884 @default.
- W1990455719 cites W2002250549 @default.
- W1990455719 cites W2006722081 @default.
- W1990455719 cites W2035845442 @default.
- W1990455719 cites W2042394625 @default.
- W1990455719 cites W2049879893 @default.
- W1990455719 cites W2056661320 @default.
- W1990455719 cites W2060589548 @default.
- W1990455719 cites W2063856776 @default.
- W1990455719 cites W2079173805 @default.
- W1990455719 cites W2086636831 @default.
- W1990455719 cites W2093465585 @default.
- W1990455719 cites W2096519870 @default.
- W1990455719 cites W2108265031 @default.
- W1990455719 cites W2119288269 @default.
- W1990455719 cites W2148990678 @default.
- W1990455719 cites W2156780983 @default.
- W1990455719 cites W2162679150 @default.
- W1990455719 cites W2169652092 @default.
- W1990455719 cites W2171830917 @default.
- W1990455719 cites W2172547644 @default.
- W1990455719 cites W2245630575 @default.
- W1990455719 cites W2279830929 @default.
- W1990455719 cites W2400616252 @default.
- W1990455719 cites W55035104 @default.
- W1990455719 doi "https://doi.org/10.1016/j.neures.2012.02.011" @default.
- W1990455719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22401839" @default.
- W1990455719 hasPublicationYear "2012" @default.
- W1990455719 type Work @default.
- W1990455719 sameAs 1990455719 @default.
- W1990455719 citedByCount "8" @default.
- W1990455719 countsByYear W19904557192015 @default.
- W1990455719 countsByYear W19904557192017 @default.
- W1990455719 countsByYear W19904557192018 @default.
- W1990455719 countsByYear W19904557192021 @default.
- W1990455719 countsByYear W19904557192023 @default.
- W1990455719 crossrefType "journal-article" @default.
- W1990455719 hasAuthorship W1990455719A5014321400 @default.
- W1990455719 hasAuthorship W1990455719A5053556602 @default.
- W1990455719 hasAuthorship W1990455719A5056081259 @default.
- W1990455719 hasConcept C12554922 @default.
- W1990455719 hasConcept C131453863 @default.
- W1990455719 hasConcept C147944092 @default.
- W1990455719 hasConcept C169760540 @default.
- W1990455719 hasConcept C178790620 @default.
- W1990455719 hasConcept C185263204 @default.
- W1990455719 hasConcept C185592680 @default.
- W1990455719 hasConcept C2780723820 @default.
- W1990455719 hasConcept C551621295 @default.
- W1990455719 hasConcept C66974803 @default.
- W1990455719 hasConcept C86803240 @default.
- W1990455719 hasConcept C93872552 @default.
- W1990455719 hasConceptScore W1990455719C12554922 @default.
- W1990455719 hasConceptScore W1990455719C131453863 @default.
- W1990455719 hasConceptScore W1990455719C147944092 @default.
- W1990455719 hasConceptScore W1990455719C169760540 @default.
- W1990455719 hasConceptScore W1990455719C178790620 @default.
- W1990455719 hasConceptScore W1990455719C185263204 @default.
- W1990455719 hasConceptScore W1990455719C185592680 @default.
- W1990455719 hasConceptScore W1990455719C2780723820 @default.
- W1990455719 hasConceptScore W1990455719C551621295 @default.
- W1990455719 hasConceptScore W1990455719C66974803 @default.
- W1990455719 hasConceptScore W1990455719C86803240 @default.
- W1990455719 hasConceptScore W1990455719C93872552 @default.
- W1990455719 hasIssue "1" @default.
- W1990455719 hasLocation W19904557191 @default.
- W1990455719 hasLocation W19904557192 @default.
- W1990455719 hasOpenAccess W1990455719 @default.
- W1990455719 hasPrimaryLocation W19904557191 @default.
- W1990455719 hasRelatedWork W1982814690 @default.
- W1990455719 hasRelatedWork W1997319353 @default.
- W1990455719 hasRelatedWork W1999946984 @default.
- W1990455719 hasRelatedWork W2000449455 @default.
- W1990455719 hasRelatedWork W2322269681 @default.
- W1990455719 hasRelatedWork W2336804072 @default.
- W1990455719 hasRelatedWork W2391692355 @default.
- W1990455719 hasRelatedWork W2439783783 @default.
- W1990455719 hasRelatedWork W3201006807 @default.
- W1990455719 hasRelatedWork W4366821946 @default.
- W1990455719 hasVolume "73" @default.
- W1990455719 isParatext "false" @default.
- W1990455719 isRetracted "false" @default.
- W1990455719 magId "1990455719" @default.
- W1990455719 workType "article" @default.