Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990457191> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W1990457191 endingPage "257" @default.
- W1990457191 startingPage "248" @default.
- W1990457191 abstract "Evidence has suggested that cyclic AMP, acting through activation of the type II cyclic AMP-dependent protein kinase, may play a role in the regulation of interphase and mitotic microtubules. In order to examine the potential role of the type II cAMP-dependent kinase during mitosis, dividing PtK1 cells were microinjected with two specific inhibitors of the catalytic activity of the type II kinase. These inhibitors were a specific protein inhibitor of cAMP-dependent protein kinase (PKI) and an affinity-purified polyclonal antiserum (anti-C) directed against the catalytic subunit of the kinase. Both have been shown previously to inhibit kinase activity in vitro. Microinjection of PKI during early- to mid-prophase significantly delayed the progression of the cells through mitosis, with the greatest delay occurring in metaphase. PKI injected during prometaphase also delayed progression through mitosis but to a lesser extent. Microinjection of anti-C during early- to mid-prophase also caused a significant delay in the completion of mitosis, with many cells becoming “hung up” in prometaphase. Anti-C injected during prometaphase had little effect on subsequent progression through mitosis. Microinjection of either anti-C or PKI during metaphase had no discernible effect. No effect on anaphase movement of chromosomes was observed with any treatment. These results provide further evidence that cAMP-dependent phosphorylation may be involved in the regulation of mitosis, although whether it acts directly through regulation of mitotic spindle microtubules is unclear." @default.
- W1990457191 created "2016-06-24" @default.
- W1990457191 creator A5019412028 @default.
- W1990457191 creator A5029162473 @default.
- W1990457191 creator A5052367334 @default.
- W1990457191 date "1987-01-01" @default.
- W1990457191 modified "2023-09-24" @default.
- W1990457191 title "Effect of inhibition of the catalytic activity of cyclic amp-dependent protein kinase on mitosis in PtK1 cells" @default.
- W1990457191 cites W1500288237 @default.
- W1990457191 cites W1558592232 @default.
- W1990457191 cites W1567714394 @default.
- W1990457191 cites W1570227839 @default.
- W1990457191 cites W1598316265 @default.
- W1990457191 cites W1963722971 @default.
- W1990457191 cites W1965620974 @default.
- W1990457191 cites W1974389412 @default.
- W1990457191 cites W1979769675 @default.
- W1990457191 cites W1989433476 @default.
- W1990457191 cites W2010820226 @default.
- W1990457191 cites W2021389852 @default.
- W1990457191 cites W2049073646 @default.
- W1990457191 cites W2055033359 @default.
- W1990457191 cites W2067562301 @default.
- W1990457191 cites W2067990781 @default.
- W1990457191 cites W2073157727 @default.
- W1990457191 cites W2077423941 @default.
- W1990457191 cites W2086392364 @default.
- W1990457191 cites W2090317875 @default.
- W1990457191 cites W2118160510 @default.
- W1990457191 cites W2127720777 @default.
- W1990457191 cites W4250847391 @default.
- W1990457191 doi "https://doi.org/10.1002/cm.970070307" @default.
- W1990457191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3594579" @default.
- W1990457191 hasPublicationYear "1987" @default.
- W1990457191 type Work @default.
- W1990457191 sameAs 1990457191 @default.
- W1990457191 citedByCount "10" @default.
- W1990457191 crossrefType "journal-article" @default.
- W1990457191 hasAuthorship W1990457191A5019412028 @default.
- W1990457191 hasAuthorship W1990457191A5029162473 @default.
- W1990457191 hasAuthorship W1990457191A5052367334 @default.
- W1990457191 hasConcept C104317684 @default.
- W1990457191 hasConcept C148196450 @default.
- W1990457191 hasConcept C1491633281 @default.
- W1990457191 hasConcept C153911025 @default.
- W1990457191 hasConcept C154202817 @default.
- W1990457191 hasConcept C184235292 @default.
- W1990457191 hasConcept C29537977 @default.
- W1990457191 hasConcept C30481170 @default.
- W1990457191 hasConcept C45413362 @default.
- W1990457191 hasConcept C53420372 @default.
- W1990457191 hasConcept C55493867 @default.
- W1990457191 hasConcept C70278784 @default.
- W1990457191 hasConcept C86803240 @default.
- W1990457191 hasConcept C93304396 @default.
- W1990457191 hasConcept C95444343 @default.
- W1990457191 hasConcept C97029542 @default.
- W1990457191 hasConceptScore W1990457191C104317684 @default.
- W1990457191 hasConceptScore W1990457191C148196450 @default.
- W1990457191 hasConceptScore W1990457191C1491633281 @default.
- W1990457191 hasConceptScore W1990457191C153911025 @default.
- W1990457191 hasConceptScore W1990457191C154202817 @default.
- W1990457191 hasConceptScore W1990457191C184235292 @default.
- W1990457191 hasConceptScore W1990457191C29537977 @default.
- W1990457191 hasConceptScore W1990457191C30481170 @default.
- W1990457191 hasConceptScore W1990457191C45413362 @default.
- W1990457191 hasConceptScore W1990457191C53420372 @default.
- W1990457191 hasConceptScore W1990457191C55493867 @default.
- W1990457191 hasConceptScore W1990457191C70278784 @default.
- W1990457191 hasConceptScore W1990457191C86803240 @default.
- W1990457191 hasConceptScore W1990457191C93304396 @default.
- W1990457191 hasConceptScore W1990457191C95444343 @default.
- W1990457191 hasConceptScore W1990457191C97029542 @default.
- W1990457191 hasIssue "3" @default.
- W1990457191 hasLocation W19904571911 @default.
- W1990457191 hasLocation W19904571912 @default.
- W1990457191 hasOpenAccess W1990457191 @default.
- W1990457191 hasPrimaryLocation W19904571911 @default.
- W1990457191 hasRelatedWork W1990457191 @default.
- W1990457191 hasRelatedWork W2013879849 @default.
- W1990457191 hasRelatedWork W2033800255 @default.
- W1990457191 hasRelatedWork W2052345204 @default.
- W1990457191 hasRelatedWork W2056316890 @default.
- W1990457191 hasRelatedWork W2118972759 @default.
- W1990457191 hasRelatedWork W2253717600 @default.
- W1990457191 hasRelatedWork W2275386138 @default.
- W1990457191 hasRelatedWork W2524253397 @default.
- W1990457191 hasRelatedWork W2888484271 @default.
- W1990457191 hasVolume "7" @default.
- W1990457191 isParatext "false" @default.
- W1990457191 isRetracted "false" @default.
- W1990457191 magId "1990457191" @default.
- W1990457191 workType "article" @default.