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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990458022> ?p ?o ?g. }

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• W1990458022 abstract "ABSTRACT We previously reported mutations in North American West Nile viruses (WNVs) with a small-plaque ( sp ), temperature-sensitive ( ts ), and/or mouse-attenuated ( att ) phenotype. Using an infectious clone, site-directed mutations and 3′ untranslated region (3′UTR) exchanges were introduced into the WNV NY99 genome. Characterization of mutants demonstrated that a combination of mutations involving the NS4B protein (E249G) together with either a mutation in the NS5 protein (A804V) or three mutations in the 3′UTR (A10596G, C10774U, A10799G) produced sp , ts , and/or att variants. These results suggested that the discovery of North American WNV-phenotypic variants is rare because of the apparent requirement of concurrent polygenic mutations." @default.
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• W1990458022 date "2007-06-01" @default.
• W1990458022 modified "2023-09-23" @default.
• W1990458022 title "A Combination of Naturally Occurring Mutations in North American West Nile Virus Nonstructural Protein Genes and in the 3′ Untranslated Region Alters Virus Phenotype" @default.
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• W1990458022 doi "https://doi.org/10.1128/jvi.02387-06" @default.
• W1990458022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1900292" @default.
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