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- W1990458210 abstract "As predicted by systems biology, a paradigm shift will emerge through the integration of information about different layers of cellular processes. The cell cycle network is at the heart of the cellular computing system, and orchestrates versatile cellular functions. The NIRF/UHRF2 ubiquitin ligase is an “intermodular hub” that occupies a central position in the network, and facilitates coordination among the cell cycle machinery, the ubiquitin–proteasome system, and the epigenetic system. NIRF interacts with cyclins, CDKs, p53, pRB, PCNA, HDAC1, DNMTs, G9a, methylated histone H3 lysine 9, and methylated DNA. NIRF ubiquitinates cyclins D1 and E1, and induces G1 arrest. The NIRF gene is frequently lost in tumors and is a candidate tumor suppressor, while its paralog, the UHRF1 gene, is hardly altered. Thus, investigations of NIRF are essential to understand the entire biological systems. Through integration of the enormous information flows, NIRF may contribute to the coupling between the cell cycle network and the epigenetic landscape. We propose the new paradigm that NIRF produces the extreme diversity in the network wiring that helps the diversity of Waddington's canals." @default.
- W1990458210 created "2016-06-24" @default.
- W1990458210 creator A5013918876 @default.
- W1990458210 creator A5052716791 @default.
- W1990458210 creator A5076462313 @default.
- W1990458210 creator A5079062648 @default.
- W1990458210 date "2012-04-30" @default.
- W1990458210 modified "2023-10-17" @default.
- W1990458210 title "NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape" @default.
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