Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990465720> ?p ?o ?g. }
- W1990465720 endingPage "1810" @default.
- W1990465720 startingPage "1802" @default.
- W1990465720 abstract "Hepatocellular carcinoma is a common type of cancer with poor prognosis. This study examines the in vitro and in vivo mechanisms of diosmin on human hepato-cellular carcinoma HA22T cell proliferation inhibition. HA22T cells were treated with different diosmin concentrations and analyzed with Western blot analysis, MTT assay, wound healing, flow cytometry, siRNA transfection assays and co-immuno-precipitation assay. The HA22T-implanted xeno-graft nude mice model was applied to confirm the cellular effects. Diosmin showed strong HA22T cell viability inhibition in a dose dependent manner and significantly reduced the cell proliferative proteins as well as inducing cell cycle arrest in the G2/M phase through p53 activation and PI3K–Akt–MDM2 signaling pathway inhibition. However, protein phosphatase 2A (PP2A) siRNA or PP2A inhibitor totally reversed the diosmin effects. The HA22T-implanted nude mice model further confirmed that diosmin inhibited HA22T tumor cell growth and down regulated the PI3K–Akt–MDM2 signaling and cell cycle regulating proteins, as well as activating PP2A and p53 proteins. Our findings indicate that HA22T cell proliferation inhibition and tumor growth suppression by diosmin are mediated through PP2A activation." @default.
- W1990465720 created "2016-06-24" @default.
- W1990465720 creator A5016123406 @default.
- W1990465720 creator A5026102216 @default.
- W1990465720 creator A5032006263 @default.
- W1990465720 creator A5032661723 @default.
- W1990465720 creator A5047600604 @default.
- W1990465720 creator A5047609838 @default.
- W1990465720 creator A5053588259 @default.
- W1990465720 creator A5056909923 @default.
- W1990465720 creator A5073536677 @default.
- W1990465720 creator A5074006227 @default.
- W1990465720 creator A5089005621 @default.
- W1990465720 date "2012-05-01" @default.
- W1990465720 modified "2023-10-09" @default.
- W1990465720 title "PP2A mediates diosmin p53 activation to block HA22T cell proliferation and tumor growth in xenografted nude mice through PI3K–Akt–MDM2 signaling suppression" @default.
- W1990465720 cites W1520797890 @default.
- W1990465720 cites W165590492 @default.
- W1990465720 cites W1966337346 @default.
- W1990465720 cites W1970682153 @default.
- W1990465720 cites W1970693756 @default.
- W1990465720 cites W1975032153 @default.
- W1990465720 cites W1981083415 @default.
- W1990465720 cites W1983107157 @default.
- W1990465720 cites W1992366030 @default.
- W1990465720 cites W1996532455 @default.
- W1990465720 cites W1999928502 @default.
- W1990465720 cites W2018702059 @default.
- W1990465720 cites W2023229316 @default.
- W1990465720 cites W2029080338 @default.
- W1990465720 cites W2036816656 @default.
- W1990465720 cites W2040127848 @default.
- W1990465720 cites W2046024621 @default.
- W1990465720 cites W2046207683 @default.
- W1990465720 cites W2050745715 @default.
- W1990465720 cites W2062712010 @default.
- W1990465720 cites W2065465120 @default.
- W1990465720 cites W2071534171 @default.
- W1990465720 cites W2072482644 @default.
- W1990465720 cites W2074545297 @default.
- W1990465720 cites W2074820129 @default.
- W1990465720 cites W2081519294 @default.
- W1990465720 cites W2106735070 @default.
- W1990465720 cites W2119361029 @default.
- W1990465720 cites W2122164502 @default.
- W1990465720 cites W2145200068 @default.
- W1990465720 cites W2167184679 @default.
- W1990465720 cites W2168323414 @default.
- W1990465720 cites W952406814 @default.
- W1990465720 doi "https://doi.org/10.1016/j.fct.2012.01.021" @default.
- W1990465720 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22289577" @default.
- W1990465720 hasPublicationYear "2012" @default.
- W1990465720 type Work @default.
- W1990465720 sameAs 1990465720 @default.
- W1990465720 citedByCount "39" @default.
- W1990465720 countsByYear W19904657202013 @default.
- W1990465720 countsByYear W19904657202014 @default.
- W1990465720 countsByYear W19904657202015 @default.
- W1990465720 countsByYear W19904657202016 @default.
- W1990465720 countsByYear W19904657202017 @default.
- W1990465720 countsByYear W19904657202018 @default.
- W1990465720 countsByYear W19904657202019 @default.
- W1990465720 countsByYear W19904657202020 @default.
- W1990465720 countsByYear W19904657202021 @default.
- W1990465720 countsByYear W19904657202022 @default.
- W1990465720 countsByYear W19904657202023 @default.
- W1990465720 crossrefType "journal-article" @default.
- W1990465720 hasAuthorship W1990465720A5016123406 @default.
- W1990465720 hasAuthorship W1990465720A5026102216 @default.
- W1990465720 hasAuthorship W1990465720A5032006263 @default.
- W1990465720 hasAuthorship W1990465720A5032661723 @default.
- W1990465720 hasAuthorship W1990465720A5047600604 @default.
- W1990465720 hasAuthorship W1990465720A5047609838 @default.
- W1990465720 hasAuthorship W1990465720A5053588259 @default.
- W1990465720 hasAuthorship W1990465720A5056909923 @default.
- W1990465720 hasAuthorship W1990465720A5073536677 @default.
- W1990465720 hasAuthorship W1990465720A5074006227 @default.
- W1990465720 hasAuthorship W1990465720A5089005621 @default.
- W1990465720 hasConcept C11960822 @default.
- W1990465720 hasConcept C1491633281 @default.
- W1990465720 hasConcept C178666793 @default.
- W1990465720 hasConcept C184235292 @default.
- W1990465720 hasConcept C2776062698 @default.
- W1990465720 hasConcept C2778004101 @default.
- W1990465720 hasConcept C2778198054 @default.
- W1990465720 hasConcept C2779054382 @default.
- W1990465720 hasConcept C2780565469 @default.
- W1990465720 hasConcept C29537977 @default.
- W1990465720 hasConcept C389152 @default.
- W1990465720 hasConcept C502942594 @default.
- W1990465720 hasConcept C55493867 @default.
- W1990465720 hasConcept C62112901 @default.
- W1990465720 hasConcept C62478195 @default.
- W1990465720 hasConcept C75217442 @default.
- W1990465720 hasConcept C86554907 @default.
- W1990465720 hasConcept C86803240 @default.
- W1990465720 hasConcept C95444343 @default.
- W1990465720 hasConceptScore W1990465720C11960822 @default.