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- W1990471921 abstract "Treatment of rat reticulocytes with isoproterenol caused about 50, 25, and 25% decreases in β-adrenergic agonist-, fluoride-, and guanine nucleotide-stimulated adenylate cyclase activities, respectively. The desensitization was also induced by dibutyryl adenosine 3', 5'-cyclic monophosphate (cyclic AMP) and 1-(5-isoquinolinylsulfonyl)-2-methylpiperazine (H-7) prevented the isoproterenol-induced desensitization, suggesting the involvement of cyclic AMP in the desensitization. Time course studies revealed that the desensitization to NaF-AlCl3 occurred faster than that to isoproterenol. Furthermore, the rate of the resensitization to NaF-AlCl3 by removal of isoproterenol was also faster than that to isoproterenol. Thus, it is likely that both guanine nucleotide-binding stimulatory regulatory protein, Ns, and β-adrenergic receptor are sequentially involved in both desensitization and resensitization of the adenylate cyclase system in rat reticulocytes to isoproterenol." @default.
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- W1990471921 date "1987-01-01" @default.
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- W1990471921 title "Characterization of heterologous desensitization of rat reticulocyte adenylate cyclase system." @default.
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- W1990471921 doi "https://doi.org/10.1248/bpb1978.10.250" @default.
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