Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990474105> ?p ?o ?g. }
- W1990474105 abstract "Rho family proteins are constitutively activated in the highly invasive human fibrosarcoma HT1080 cells. We now investigated the specific roles of Rac1 and Rac2 in regulating morphology, F-actin organization, adhesion, migration, and chemotaxis of HT1080 cells. Downregulation of Rac1 using specific siRNA probes resulted in cell rounding, markedly decreased spreading, adhesion, and chemotaxis of HT1080 cells. 2D migration on laminin-coated surfaces in contrast was not markedly affected. Selective Rac2 depletion did not affect cell morphology, cell adhesion, and 2D migration, but significantly reduced chemotaxis. Downregulation of both Rac1 and Rac2 resulted in an even more marked reduction, but not complete abolishment, of chemotaxis indicating distinct as well as overlapping roles of both proteins in chemotaxis. Rac1 thus is selectively required for HT1080 cell spreading and adhesion whereas Rac1 and Rac2 are both required for efficient chemotaxis." @default.
- W1990474105 created "2016-06-24" @default.
- W1990474105 creator A5000495358 @default.
- W1990474105 creator A5021138046 @default.
- W1990474105 creator A5049832798 @default.
- W1990474105 date "2009-09-01" @default.
- W1990474105 modified "2023-09-25" @default.
- W1990474105 title "Specific roles of Rac1 and Rac2 in motile functions of HT1080 fibrosarcoma cells" @default.
- W1990474105 cites W1523918896 @default.
- W1990474105 cites W1568345151 @default.
- W1990474105 cites W1775749144 @default.
- W1990474105 cites W1970537259 @default.
- W1990474105 cites W1974514343 @default.
- W1990474105 cites W1991777734 @default.
- W1990474105 cites W1999088044 @default.
- W1990474105 cites W2009662773 @default.
- W1990474105 cites W2010630254 @default.
- W1990474105 cites W2019528050 @default.
- W1990474105 cites W2022979286 @default.
- W1990474105 cites W2032713332 @default.
- W1990474105 cites W2035643930 @default.
- W1990474105 cites W2040443947 @default.
- W1990474105 cites W2044441008 @default.
- W1990474105 cites W2049218641 @default.
- W1990474105 cites W2050383784 @default.
- W1990474105 cites W2060630299 @default.
- W1990474105 cites W2083543572 @default.
- W1990474105 cites W2086641174 @default.
- W1990474105 cites W2103040045 @default.
- W1990474105 cites W2113245366 @default.
- W1990474105 cites W2121545064 @default.
- W1990474105 cites W2123129088 @default.
- W1990474105 cites W2135889062 @default.
- W1990474105 cites W2149290707 @default.
- W1990474105 cites W2157246902 @default.
- W1990474105 cites W2166676058 @default.
- W1990474105 doi "https://doi.org/10.1016/j.bbrc.2009.06.098" @default.
- W1990474105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19555660" @default.
- W1990474105 hasPublicationYear "2009" @default.
- W1990474105 type Work @default.
- W1990474105 sameAs 1990474105 @default.
- W1990474105 citedByCount "10" @default.
- W1990474105 countsByYear W19904741052013 @default.
- W1990474105 countsByYear W19904741052014 @default.
- W1990474105 countsByYear W19904741052015 @default.
- W1990474105 countsByYear W19904741052021 @default.
- W1990474105 crossrefType "journal-article" @default.
- W1990474105 hasAuthorship W1990474105A5000495358 @default.
- W1990474105 hasAuthorship W1990474105A5021138046 @default.
- W1990474105 hasAuthorship W1990474105A5049832798 @default.
- W1990474105 hasConcept C104317684 @default.
- W1990474105 hasConcept C127561419 @default.
- W1990474105 hasConcept C137738243 @default.
- W1990474105 hasConcept C1491633281 @default.
- W1990474105 hasConcept C170493617 @default.
- W1990474105 hasConcept C178790620 @default.
- W1990474105 hasConcept C185592680 @default.
- W1990474105 hasConcept C2776495794 @default.
- W1990474105 hasConcept C2777751087 @default.
- W1990474105 hasConcept C2779717556 @default.
- W1990474105 hasConcept C54166955 @default.
- W1990474105 hasConcept C54355233 @default.
- W1990474105 hasConcept C55493867 @default.
- W1990474105 hasConcept C62478195 @default.
- W1990474105 hasConcept C84416704 @default.
- W1990474105 hasConcept C85789140 @default.
- W1990474105 hasConcept C86803240 @default.
- W1990474105 hasConcept C95444343 @default.
- W1990474105 hasConceptScore W1990474105C104317684 @default.
- W1990474105 hasConceptScore W1990474105C127561419 @default.
- W1990474105 hasConceptScore W1990474105C137738243 @default.
- W1990474105 hasConceptScore W1990474105C1491633281 @default.
- W1990474105 hasConceptScore W1990474105C170493617 @default.
- W1990474105 hasConceptScore W1990474105C178790620 @default.
- W1990474105 hasConceptScore W1990474105C185592680 @default.
- W1990474105 hasConceptScore W1990474105C2776495794 @default.
- W1990474105 hasConceptScore W1990474105C2777751087 @default.
- W1990474105 hasConceptScore W1990474105C2779717556 @default.
- W1990474105 hasConceptScore W1990474105C54166955 @default.
- W1990474105 hasConceptScore W1990474105C54355233 @default.
- W1990474105 hasConceptScore W1990474105C55493867 @default.
- W1990474105 hasConceptScore W1990474105C62478195 @default.
- W1990474105 hasConceptScore W1990474105C84416704 @default.
- W1990474105 hasConceptScore W1990474105C85789140 @default.
- W1990474105 hasConceptScore W1990474105C86803240 @default.
- W1990474105 hasConceptScore W1990474105C95444343 @default.
- W1990474105 hasLocation W19904741051 @default.
- W1990474105 hasLocation W19904741052 @default.
- W1990474105 hasOpenAccess W1990474105 @default.
- W1990474105 hasPrimaryLocation W19904741051 @default.
- W1990474105 hasRelatedWork W1987899788 @default.
- W1990474105 hasRelatedWork W1989752115 @default.
- W1990474105 hasRelatedWork W2009878560 @default.
- W1990474105 hasRelatedWork W2013853152 @default.
- W1990474105 hasRelatedWork W2028726891 @default.
- W1990474105 hasRelatedWork W2029672056 @default.
- W1990474105 hasRelatedWork W2052907252 @default.
- W1990474105 hasRelatedWork W2070508820 @default.
- W1990474105 hasRelatedWork W2072069418 @default.
- W1990474105 hasRelatedWork W2074520875 @default.