Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990474450> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W1990474450 endingPage "PL51" @default.
- W1990474450 startingPage "PL47" @default.
- W1990474450 abstract "The objective of this study was to determine whether chronic morphine exposure increased P-glycoprotein in rat brain. Male Sprague-Dawley rats were treated with morphine, saline, or dexamethasone for 5 days. On day 6, antinociceptive effect was measured to evaluate the extent of functional tolerance to morphine. Brain P-glycoprotein was detected by Western blot analysis of whole brain homogenate. Morphine- and dexamethasone-treated rats exhibited decreased antinociceptive response when compared to saline-treated controls. Brain P-glycoprotein was approximately 2-fold higher in morphine-treated rats compared to saline controls based on Western blot analysis. Chronic morphine exposure appears to increase P-glycoprotein in rat brain. P-glycoprotein induction may enhance morphine efflux from the brain, thus reducing morphine's pharmacologic activity. Induction of P-glycoprotein may be one mechanism involved in the development of morphine tolerance." @default.
- W1990474450 created "2016-06-24" @default.
- W1990474450 creator A5025624246 @default.
- W1990474450 creator A5038073546 @default.
- W1990474450 creator A5049414071 @default.
- W1990474450 creator A5090830617 @default.
- W1990474450 date "1999-12-01" @default.
- W1990474450 modified "2023-10-12" @default.
- W1990474450 title "Increased brain P-glycoprotein in morphine tolerant rats" @default.
- W1990474450 cites W1569290580 @default.
- W1990474450 cites W171291377 @default.
- W1990474450 cites W1775749144 @default.
- W1990474450 cites W1974856490 @default.
- W1990474450 cites W2011800934 @default.
- W1990474450 cites W2049520769 @default.
- W1990474450 cites W2067746647 @default.
- W1990474450 cites W2088060636 @default.
- W1990474450 cites W2091266010 @default.
- W1990474450 cites W2310633686 @default.
- W1990474450 cites W4245797813 @default.
- W1990474450 doi "https://doi.org/10.1016/s0024-3205(99)00599-8" @default.
- W1990474450 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10665989" @default.
- W1990474450 hasPublicationYear "1999" @default.
- W1990474450 type Work @default.
- W1990474450 sameAs 1990474450 @default.
- W1990474450 citedByCount "69" @default.
- W1990474450 countsByYear W19904744502012 @default.
- W1990474450 countsByYear W19904744502013 @default.
- W1990474450 countsByYear W19904744502014 @default.
- W1990474450 countsByYear W19904744502015 @default.
- W1990474450 countsByYear W19904744502017 @default.
- W1990474450 countsByYear W19904744502018 @default.
- W1990474450 countsByYear W19904744502019 @default.
- W1990474450 countsByYear W19904744502020 @default.
- W1990474450 countsByYear W19904744502021 @default.
- W1990474450 countsByYear W19904744502022 @default.
- W1990474450 countsByYear W19904744502023 @default.
- W1990474450 crossrefType "journal-article" @default.
- W1990474450 hasAuthorship W1990474450A5025624246 @default.
- W1990474450 hasAuthorship W1990474450A5038073546 @default.
- W1990474450 hasAuthorship W1990474450A5049414071 @default.
- W1990474450 hasAuthorship W1990474450A5090830617 @default.
- W1990474450 hasConcept C104317684 @default.
- W1990474450 hasConcept C126322002 @default.
- W1990474450 hasConcept C133936738 @default.
- W1990474450 hasConcept C134018914 @default.
- W1990474450 hasConcept C15490471 @default.
- W1990474450 hasConcept C170493617 @default.
- W1990474450 hasConcept C185592680 @default.
- W1990474450 hasConcept C2776415932 @default.
- W1990474450 hasConcept C2777389121 @default.
- W1990474450 hasConcept C2777397205 @default.
- W1990474450 hasConcept C2778707650 @default.
- W1990474450 hasConcept C2780401358 @default.
- W1990474450 hasConcept C2780820201 @default.
- W1990474450 hasConcept C501593827 @default.
- W1990474450 hasConcept C55493867 @default.
- W1990474450 hasConcept C71924100 @default.
- W1990474450 hasConcept C98274493 @default.
- W1990474450 hasConceptScore W1990474450C104317684 @default.
- W1990474450 hasConceptScore W1990474450C126322002 @default.
- W1990474450 hasConceptScore W1990474450C133936738 @default.
- W1990474450 hasConceptScore W1990474450C134018914 @default.
- W1990474450 hasConceptScore W1990474450C15490471 @default.
- W1990474450 hasConceptScore W1990474450C170493617 @default.
- W1990474450 hasConceptScore W1990474450C185592680 @default.
- W1990474450 hasConceptScore W1990474450C2776415932 @default.
- W1990474450 hasConceptScore W1990474450C2777389121 @default.
- W1990474450 hasConceptScore W1990474450C2777397205 @default.
- W1990474450 hasConceptScore W1990474450C2778707650 @default.
- W1990474450 hasConceptScore W1990474450C2780401358 @default.
- W1990474450 hasConceptScore W1990474450C2780820201 @default.
- W1990474450 hasConceptScore W1990474450C501593827 @default.
- W1990474450 hasConceptScore W1990474450C55493867 @default.
- W1990474450 hasConceptScore W1990474450C71924100 @default.
- W1990474450 hasConceptScore W1990474450C98274493 @default.
- W1990474450 hasIssue "4" @default.
- W1990474450 hasLocation W19904744501 @default.
- W1990474450 hasLocation W19904744502 @default.
- W1990474450 hasOpenAccess W1990474450 @default.
- W1990474450 hasPrimaryLocation W19904744501 @default.
- W1990474450 hasRelatedWork W1976485394 @default.
- W1990474450 hasRelatedWork W1993503604 @default.
- W1990474450 hasRelatedWork W2011717172 @default.
- W1990474450 hasRelatedWork W2067693794 @default.
- W1990474450 hasRelatedWork W2072614072 @default.
- W1990474450 hasRelatedWork W2077416684 @default.
- W1990474450 hasRelatedWork W2153052119 @default.
- W1990474450 hasRelatedWork W2748952813 @default.
- W1990474450 hasRelatedWork W4206871862 @default.
- W1990474450 hasRelatedWork W4287435042 @default.
- W1990474450 hasVolume "66" @default.
- W1990474450 isParatext "false" @default.
- W1990474450 isRetracted "false" @default.
- W1990474450 magId "1990474450" @default.
- W1990474450 workType "article" @default.