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• W1990487655 endingPage "1416" @default.
• W1990487655 startingPage "1397" @default.
• W1990487655 abstract "Accumulating evidence suggests that there is a rich cross-talk between the neuroimmune system and neuroplasticity mechanisms under both physiological conditions and pathophysiological conditions in depression. Anti-neuroplastic changes which occur in depression include a decrease in proliferation of neural stem cells (NSCs), decreased survival of neuroblasts and immature neurons, impaired neurocircuitry (cortical-striatal-limbic circuits), reduced levels of neurotrophins, reduced spine density and dendritic retraction. Since both humoral and cellular immune factors have been implicated in neuroplastic processes, in this review we present a model suggesting that neuroplastic processes in depression are mediated through various neuroimmune mechanisms. The review puts forward a model in that both humoral and cellular neuroimmune factors are involved with impairing neuroplasticity under pathophysiological conditions such as depression. Specifically, neuroimmune factors including interleukin (IL)-1, IL-6, tumour necrosis factor (TNF)-α, CD4⁺CD25⁺T regulatory cells (T reg), self-specific CD4⁺T cells, monocyte-derived macrophages, microglia and astrocytes are shown to be vital to processes of neuroplasticity such as long-term potentiation (LTP), NSC survival, synaptic branching, neurotrophin regulation and neurogenesis. In rodent models of depression, IL-1, IL-6 and TNF are associated with reduced hippocampal neurogenesis; mechanisms which are associated with this include the stress-activated protein kinase (SAPK)/Janus Kinase (JNK) pathway, hypoxia-inducible factors (HIF)-1α, JAK-Signal Transducer and Activator of Transcription (STAT) pathway, mitogen-activated protein kinase (MAPK)/cAMP responsive element binding protein (CREB) pathway, Ras-MAPK, PI-3 kinase, IKK/nuclear factor (NF)-κB and TGFβ activated kinase-1 (TAK-1). Neuroimmunological mechanisms have an active role in the neuroplastic changes associated with depression. Since therapies in depression, including antidepressants (AD), omega-3 polyunsaturated fatty acids (PUFAs) and physical activity exert neuroplasticity-enhancing effects potentially mediated by neuroimmune mechanisms, the immune system might serve as a promising target for interventions in depression." @default.
• W1990487655 created "2016-06-24" @default.
• W1990487655 creator A5031084817 @default.
• W1990487655 creator A5035122667 @default.
• W1990487655 date "2012-09-01" @default.
• W1990487655 modified "2023-09-30" @default.
• W1990487655 title "Neuroplastic changes in depression: A role for the immune system" @default.
• W1990487655 cites W1479791469 @default.
• W1990487655 cites W1482709215 @default.
• W1990487655 cites W1484832749 @default.
• W1990487655 cites W1509596990 @default.
• W1990487655 cites W1522165824 @default.
• W1990487655 cites W1522823711 @default.
• W1990487655 cites W1542136448 @default.
• W1990487655 cites W1547955534 @default.
• W1990487655 cites W1553210510 @default.
• W1990487655 cites W1591586719 @default.
• W1990487655 cites W1619322898 @default.
• W1990487655 cites W1806270851 @default.
• W1990487655 cites W1868273134 @default.
• W1990487655 cites W1903439047 @default.
• W1990487655 cites W1960145271 @default.
• W1990487655 cites W1962996875 @default.
• W1990487655 cites W1963805149 @default.
• W1990487655 cites W1965381097 @default.
• W1990487655 cites W1965976131 @default.
• W1990487655 cites W1966424136 @default.
• W1990487655 cites W1966600718 @default.
• W1990487655 cites W1969000212 @default.
• W1990487655 cites W1969392677 @default.
• W1990487655 cites W1970891635 @default.
• W1990487655 cites W1971004772 @default.
• W1990487655 cites W1971701647 @default.
• W1990487655 cites W1972187375 @default.
• W1990487655 cites W1973172818 @default.
• W1990487655 cites W1973418455 @default.
• W1990487655 cites W1973667548 @default.
• W1990487655 cites W1974959454 @default.
• W1990487655 cites W1976702427 @default.
• W1990487655 cites W1977240581 @default.
• W1990487655 cites W1978328220 @default.
• W1990487655 cites W1978606674 @default.
• W1990487655 cites W1978702665 @default.
• W1990487655 cites W1978830885 @default.
• W1990487655 cites W1978836458 @default.
• W1990487655 cites W1979347549 @default.
• W1990487655 cites W1980438098 @default.
• W1990487655 cites W1980843720 @default.
• W1990487655 cites W1982337563 @default.
• W1990487655 cites W1982437447 @default.
• W1990487655 cites W1983465575 @default.
• W1990487655 cites W1983617759 @default.
• W1990487655 cites W1983629204 @default.
• W1990487655 cites W1984437024 @default.
• W1990487655 cites W1984680724 @default.
• W1990487655 cites W1985438873 @default.
• W1990487655 cites W1985680749 @default.
• W1990487655 cites W1986195447 @default.
• W1990487655 cites W1986678411 @default.
• W1990487655 cites W1987945720 @default.
• W1990487655 cites W1988105902 @default.
• W1990487655 cites W1988200425 @default.
• W1990487655 cites W1988210171 @default.
• W1990487655 cites W1989060739 @default.
• W1990487655 cites W1989199068 @default.
• W1990487655 cites W1989369404 @default.
• W1990487655 cites W1989375959 @default.
• W1990487655 cites W1990583458 @default.
• W1990487655 cites W1990626639 @default.
• W1990487655 cites W1993025459 @default.
• W1990487655 cites W1993856151 @default.
• W1990487655 cites W1995800438 @default.
• W1990487655 cites W1996303231 @default.
• W1990487655 cites W1996454121 @default.
• W1990487655 cites W1996826305 @default.
• W1990487655 cites W1997132511 @default.
• W1990487655 cites W1998000193 @default.
• W1990487655 cites W1998878650 @default.
• W1990487655 cites W1999001824 @default.
• W1990487655 cites W2000779607 @default.
• W1990487655 cites W2001997781 @default.
• W1990487655 cites W2002101479 @default.
• W1990487655 cites W2002161951 @default.
• W1990487655 cites W2002353472 @default.
• W1990487655 cites W2003674452 @default.
• W1990487655 cites W2005982631 @default.
• W1990487655 cites W2006187420 @default.
• W1990487655 cites W2006548108 @default.
• W1990487655 cites W2006585084 @default.
• W1990487655 cites W2007511428 @default.
• W1990487655 cites W2008113854 @default.
• W1990487655 cites W2008362959 @default.
• W1990487655 cites W2011495546 @default.
• W1990487655 cites W2011937563 @default.
• W1990487655 cites W2012267125 @default.
• W1990487655 cites W2012805935 @default.
• W1990487655 cites W2013551728 @default.
• W1990487655 cites W2013887960 @default.

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