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- W1990497594 abstract "The biodistribution of the radioiodinated monoclonal antibody KS1/4 and of its F(ab) and F(ab')2 fragments were studied in tumor-bearing nude mice. Intravenous administration of the intact antibody resulted in the highest tumor retention and tumor/blood ratios. No metabolites or antigen-antibody conjugates were detectable, in serum, by HPLC analyses. Reasonable correlations were obtained between the estimated time-course of KS1/4 and experimental biodistribution data using an eight-compartment linear radiopharmacokinetic model, suggesting that such models may be useful in predicting the biodistribution and effective targeting of this monoclonal antibody." @default.
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- W1990497594 date "1989-01-01" @default.
- W1990497594 modified "2023-10-17" @default.
- W1990497594 title "Compartmental biodistribution of a monoclonal antibody against human lung adenocarcinoma grown in athymic mice" @default.
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- W1990497594 doi "https://doi.org/10.1016/0883-2897(89)90212-2" @default.
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