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• W1990498053 abstract "Abstract Objective As to understand the sphingosine-1-phosphate (S1P) on gene expression of the pre-implantation mouse embryo induced by C 2 -Ceramide (CED). Materials and methods Global gene-expression profiling of two cell mouse embryo was performed using Affymetrix Gene Chip® Mouse Genome 430 2.0 Array. Results Fifty-five genes were identified with significant expression changes that are functionally involved in the two cell embryo after treated by S1P and CED. Of these genes, 30 were up-regulated and 25 were down-regulated. Genes Atm, Cdkn1b and Fgrfr2 are identified to be involved in the protective role of S1P against the apoptotic signals induced by CED. Conclusions This study provides a map of genes in the pre-implantation two cell mouse embryo. Further investigation based on these data will provide a better understanding of the effects of S1P on the pre-implantation embryos in other mammalian species, especially human." @default.
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• W1990498053 date "2014-06-01" @default.
• W1990498053 modified "2023-09-23" @default.
• W1990498053 title "Effects of sphingosine-1-phosphate on gene expression of two cell mouse embryos induced by C2-Ceramide" @default.
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• W1990498053 doi "https://doi.org/10.1016/j.mefs.2013.06.001" @default.
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