FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990504554> ?p ?o ?g. }

• W1990504554 endingPage "265" @default.
• W1990504554 startingPage "262" @default.
• W1990504554 abstract "See article by Tavernier et al. [1] (pages 288–296) in this issue.In this issue of Cardiovascular Research , Tavernier et al. describe the effects of β3-adrenergic stimulation on cardiac contractility in mice overexpressing the human β3-adrenoceptor (β3-AR) [1]. This study is a logical sequel to preceding investigations by the same research group that also provided the first evidence of the existence and functional role of this AR subtype in the human heart [2]. That time it was found that in contrast to the classical effects of β1-/β2-adrenergic system—positive inotropy and lusitropy—activation of β3-AR results in negative inotropy via a Gi protein-dependent pathway. Further studies revealed that β3-AR stimulation attenuates cardiac contractility through increased nitric oxide (NO) production and intracellular cGMP [3,4].To further explore the properties and role of the β3-adrenergic system, Tavernier et al. [1] generated transgenic mice overexpressing the human β3-AR in cardiac cells. The human receptor was selected for two reasons: (i) compared to other species, human cardiac muscle exhibits the strongest negative inotropic effect induced by β3-AR agonists [5] and, (ii) cardiac failure in humans is associated with increased expression of β3-AR (see below). The effectiveness of gene expression was confirmed by polymerase chain reaction and Western blotting, showing human β3-AR mRNA and corresponding protein in transgenic mice, but not in wild-type mice. Then the contractility experiments were performed under the same conditions as those used earlier for human myocardium [2]. The results show that expression of β3-adrenoceptor was accompanied by decreased peak tension in response to low concentrations of β3-AR agonists (CL 316243 and SR 58611A), consistent with their β3 … *Tel.: +372-7-374-371; fax: +372-7-374-372. enn{at}ut.ee" @default.
• W1990504554 created "2016-06-24" @default.
• W1990504554 creator A5085117392 @default.
• W1990504554 date "2003-08-01" @default.
• W1990504554 modified "2023-10-17" @default.
• W1990504554 title "Negative inotropy starts with the ?-adrenoceptor" @default.
• W1990504554 cites W1963616721 @default.
• W1990504554 cites W1971972136 @default.
• W1990504554 cites W1974903652 @default.
• W1990504554 cites W1984401650 @default.
• W1990504554 cites W1997340166 @default.
• W1990504554 cites W2025642842 @default.
• W1990504554 cites W2028132379 @default.
• W1990504554 cites W2030485468 @default.
• W1990504554 cites W2040574693 @default.
• W1990504554 cites W2046610430 @default.
• W1990504554 cites W2054046898 @default.
• W1990504554 cites W2054090431 @default.
• W1990504554 cites W2090041904 @default.
• W1990504554 cites W2098474355 @default.
• W1990504554 cites W2101513893 @default.
• W1990504554 cites W2110322730 @default.
• W1990504554 cites W2110372029 @default.
• W1990504554 cites W2123162285 @default.
• W1990504554 cites W2127534732 @default.
• W1990504554 cites W2140781673 @default.
• W1990504554 cites W2145771428 @default.
• W1990504554 cites W2158587677 @default.
• W1990504554 cites W2160588689 @default.
• W1990504554 cites W2170353863 @default.
• W1990504554 cites W2330626322 @default.
• W1990504554 cites W50782754 @default.
• W1990504554 doi "https://doi.org/10.1016/s0008-6363(03)00477-2" @default.
• W1990504554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12909307" @default.
• W1990504554 hasPublicationYear "2003" @default.
• W1990504554 type Work @default.
• W1990504554 sameAs 1990504554 @default.
• W1990504554 citedByCount "5" @default.
• W1990504554 countsByYear W19905045542014 @default.
• W1990504554 countsByYear W19905045542015 @default.
• W1990504554 crossrefType "journal-article" @default.
• W1990504554 hasAuthorship W1990504554A5085117392 @default.
• W1990504554 hasBestOaLocation W19905045541 @default.
• W1990504554 hasConcept C126322002 @default.
• W1990504554 hasConcept C155710745 @default.
• W1990504554 hasConcept C164705383 @default.
• W1990504554 hasConcept C71924100 @default.
• W1990504554 hasConceptScore W1990504554C126322002 @default.
• W1990504554 hasConceptScore W1990504554C155710745 @default.
• W1990504554 hasConceptScore W1990504554C164705383 @default.
• W1990504554 hasConceptScore W1990504554C71924100 @default.
• W1990504554 hasIssue "2" @default.
• W1990504554 hasLocation W19905045541 @default.
• W1990504554 hasLocation W19905045542 @default.
• W1990504554 hasOpenAccess W1990504554 @default.
• W1990504554 hasPrimaryLocation W19905045541 @default.
• W1990504554 hasRelatedWork W2011347913 @default.
• W1990504554 hasRelatedWork W2028411150 @default.
• W1990504554 hasRelatedWork W2049397185 @default.
• W1990504554 hasRelatedWork W2073151595 @default.
• W1990504554 hasRelatedWork W2074833529 @default.
• W1990504554 hasRelatedWork W2125804349 @default.
• W1990504554 hasRelatedWork W2159512267 @default.
• W1990504554 hasRelatedWork W2304633692 @default.
• W1990504554 hasRelatedWork W2355498105 @default.
• W1990504554 hasRelatedWork W2399063111 @default.
• W1990504554 hasVolume "59" @default.
• W1990504554 isParatext "false" @default.
• W1990504554 isRetracted "false" @default.
• W1990504554 magId "1990504554" @default.
• W1990504554 workType "article" @default.