FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990504691> ?p ?o ?g. }

• W1990504691 endingPage "22" @default.
• W1990504691 startingPage "1" @default.
• W1990504691 abstract "In this review we discuss the yeast as a paradigm for the study of aging. The budding yeast Saccharomyces cerevisiae, which can proliferate in both haploid and diploid states, has been used extensively in aging research. The budding yeast divides asymmetrically to form a 'mother' cell and a bud. Two major approaches, 'budding life span' and 'stationary phase' have been used to determine 'senescence' and 'life span' in yeast. Discrepancies observed in metabolic behavior and longevity between cells studied by these two systems raise questions of how 'life span' in yeast is defined and measured. Added to this variability in experimental approach and results is the variety of yeast strains with different genetic make up used as 'wild type' and experimental organisms. Another problematic genetic point in the published studies on yeast is the use of both diploid and haploid strains. We discuss the inherent, advantageous attributes that make the yeast an attractive choice for modern biological research as well as certain pitfalls in the choice of this model for the study of aging. The significance of the purported roles of the Sir2 gene, histone deacetylases, gene silencing, rDNA circles and stress genes in determination of yeast 'life span' and aging is evaluated. The relationship between cultivation conditions and longevity are assessed. Discrepancies between the yeast and mammalian systems with regard to aging are pointed out. We discuss unresolved problems concerning the suitability of the budding yeast for the study of basic aging phenomena." @default.
• W1990504691 created "2016-06-24" @default.
• W1990504691 creator A5003634812 @default.
• W1990504691 creator A5014033550 @default.
• W1990504691 date "2000-12-01" @default.
• W1990504691 modified "2023-10-02" @default.
• W1990504691 title "The budding yeast, Saccharomyces cerevisiae, as a model for aging research: a critical review" @default.
• W1990504691 cites W1503695145 @default.
• W1990504691 cites W1522402713 @default.
• W1990504691 cites W1912625738 @default.
• W1990504691 cites W1951075546 @default.
• W1990504691 cites W1963578989 @default.
• W1990504691 cites W1963954263 @default.
• W1990504691 cites W1967178850 @default.
• W1990504691 cites W1967344134 @default.
• W1990504691 cites W1973716822 @default.
• W1990504691 cites W1979917565 @default.
• W1990504691 cites W1984044253 @default.
• W1990504691 cites W1984677774 @default.
• W1990504691 cites W1989136135 @default.
• W1990504691 cites W1991994390 @default.
• W1990504691 cites W1992663222 @default.
• W1990504691 cites W2003440912 @default.
• W1990504691 cites W2008014792 @default.
• W1990504691 cites W2011482325 @default.
• W1990504691 cites W2014986898 @default.
• W1990504691 cites W2030532947 @default.
• W1990504691 cites W2030659161 @default.
• W1990504691 cites W2033596981 @default.
• W1990504691 cites W2037553257 @default.
• W1990504691 cites W2037835822 @default.
• W1990504691 cites W2046351190 @default.
• W1990504691 cites W2047330128 @default.
• W1990504691 cites W2047945565 @default.
• W1990504691 cites W2052330317 @default.
• W1990504691 cites W2053397454 @default.
• W1990504691 cites W2057162313 @default.
• W1990504691 cites W2059277971 @default.
• W1990504691 cites W2059665827 @default.
• W1990504691 cites W2061314148 @default.
• W1990504691 cites W2063933519 @default.
• W1990504691 cites W2064714878 @default.
• W1990504691 cites W2068693869 @default.
• W1990504691 cites W2075026875 @default.
• W1990504691 cites W2084965055 @default.
• W1990504691 cites W2085931606 @default.
• W1990504691 cites W2086137592 @default.
• W1990504691 cites W2086499357 @default.
• W1990504691 cites W2096689382 @default.
• W1990504691 cites W2097948853 @default.
• W1990504691 cites W2101868966 @default.
• W1990504691 cites W2104720774 @default.
• W1990504691 cites W2106020452 @default.
• W1990504691 cites W2111493170 @default.
• W1990504691 cites W2111905327 @default.
• W1990504691 cites W2115299520 @default.
• W1990504691 cites W2132015995 @default.
• W1990504691 cites W2133501669 @default.
• W1990504691 cites W2135951244 @default.
• W1990504691 cites W2139787825 @default.
• W1990504691 cites W2143343444 @default.
• W1990504691 cites W2153283265 @default.
• W1990504691 cites W2157649587 @default.
• W1990504691 cites W2163943333 @default.
• W1990504691 cites W2165870010 @default.
• W1990504691 cites W2170940406 @default.
• W1990504691 cites W2315694815 @default.
• W1990504691 doi "https://doi.org/10.1016/s0047-6374(00)00182-2" @default.
• W1990504691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11087900" @default.
• W1990504691 hasPublicationYear "2000" @default.
• W1990504691 type Work @default.
• W1990504691 sameAs 1990504691 @default.
• W1990504691 citedByCount "101" @default.
• W1990504691 countsByYear W19905046912012 @default.
• W1990504691 countsByYear W19905046912013 @default.
• W1990504691 countsByYear W19905046912014 @default.
• W1990504691 countsByYear W19905046912015 @default.
• W1990504691 countsByYear W19905046912016 @default.
• W1990504691 countsByYear W19905046912017 @default.
• W1990504691 countsByYear W19905046912018 @default.
• W1990504691 countsByYear W19905046912019 @default.
• W1990504691 countsByYear W19905046912020 @default.
• W1990504691 countsByYear W19905046912021 @default.
• W1990504691 countsByYear W19905046912022 @default.
• W1990504691 countsByYear W19905046912023 @default.
• W1990504691 crossrefType "journal-article" @default.
• W1990504691 hasAuthorship W1990504691A5003634812 @default.
• W1990504691 hasAuthorship W1990504691A5014033550 @default.
• W1990504691 hasConcept C104317684 @default.
• W1990504691 hasConcept C143191323 @default.
• W1990504691 hasConcept C198410946 @default.
• W1990504691 hasConcept C19843653 @default.
• W1990504691 hasConcept C2776759703 @default.
• W1990504691 hasConcept C2777576037 @default.
• W1990504691 hasConcept C2779222958 @default.
• W1990504691 hasConcept C2992884146 @default.
• W1990504691 hasConcept C522857546 @default.
• W1990504691 hasConcept C54355233 @default.

• next