Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990506571> ?p ?o ?g. }
- W1990506571 endingPage "3625" @default.
- W1990506571 startingPage "3615" @default.
- W1990506571 abstract "Abstract Intercellular adhesion molecules (ICAMs) bind to leukocyte β2 integrins, which, among other functions, provide costimulatory signals for T-cell activation. ICAM-5 (telencephalin) is expressed in the somadendritic region of neurons of the mammalian brain. The receptor for ICAM-5 is the integrin LFA-1, a major leukocyte integ-rin expressed in lymphocytes and microglia. In conditions of brain ischemia, epilepsy, and encephalitis, the soluble form of ICAM-5 (sICAM-5) has been detected in physiologic fluids. Here, we report that sICAM-5 attenuates the T-cell receptor-mediated activation of T cells as demonstrated by the decreased expression of the activation markers CD69, CD40L, and CD25 (IL-2R). This effect is most clearly seen in CD45ROLow (naive), and not in CD45ROHigh (memory) T cells, and is most effective early in priming, but not in the presence of strong costimulatory signals. Furthermore, sICAM-5 promotes the mRNA expression of the cytokines TGF-β1 and IFN-γ, but not TNF. The formation of sICAM-5 is promoted by activated T cells through the cleavage of ICAM-5 from neurons. This suggests that ICAM-5 is involved in immune privilege of the brain and acts as an anti-inflammatory agent." @default.
- W1990506571 created "2016-06-24" @default.
- W1990506571 creator A5008677905 @default.
- W1990506571 creator A5036250119 @default.
- W1990506571 creator A5046604110 @default.
- W1990506571 creator A5053103217 @default.
- W1990506571 creator A5077618588 @default.
- W1990506571 creator A5086592087 @default.
- W1990506571 date "2008-04-01" @default.
- W1990506571 modified "2023-10-11" @default.
- W1990506571 title "Shedded neuronal ICAM-5 suppresses T-cell activation" @default.
- W1990506571 cites W1500225421 @default.
- W1990506571 cites W1600348345 @default.
- W1990506571 cites W1955666311 @default.
- W1990506571 cites W1965448804 @default.
- W1990506571 cites W1968098105 @default.
- W1990506571 cites W1978850373 @default.
- W1990506571 cites W1980541855 @default.
- W1990506571 cites W1981306008 @default.
- W1990506571 cites W1983009247 @default.
- W1990506571 cites W1985432448 @default.
- W1990506571 cites W1991823448 @default.
- W1990506571 cites W1994011248 @default.
- W1990506571 cites W1996382554 @default.
- W1990506571 cites W2002967638 @default.
- W1990506571 cites W2007030947 @default.
- W1990506571 cites W2020121188 @default.
- W1990506571 cites W2021400687 @default.
- W1990506571 cites W2025554920 @default.
- W1990506571 cites W2033288474 @default.
- W1990506571 cites W2034387476 @default.
- W1990506571 cites W2037672200 @default.
- W1990506571 cites W2041556515 @default.
- W1990506571 cites W2043088736 @default.
- W1990506571 cites W2044687503 @default.
- W1990506571 cites W2048102203 @default.
- W1990506571 cites W2050206306 @default.
- W1990506571 cites W2051240154 @default.
- W1990506571 cites W2053313675 @default.
- W1990506571 cites W2058852699 @default.
- W1990506571 cites W2059980756 @default.
- W1990506571 cites W2064017800 @default.
- W1990506571 cites W2066914738 @default.
- W1990506571 cites W2069714272 @default.
- W1990506571 cites W2074736197 @default.
- W1990506571 cites W2074910450 @default.
- W1990506571 cites W2075648009 @default.
- W1990506571 cites W2076651424 @default.
- W1990506571 cites W2081689918 @default.
- W1990506571 cites W2088217656 @default.
- W1990506571 cites W2093422329 @default.
- W1990506571 cites W2093455511 @default.
- W1990506571 cites W2100449935 @default.
- W1990506571 cites W2103369019 @default.
- W1990506571 cites W2105337306 @default.
- W1990506571 cites W2108244474 @default.
- W1990506571 cites W2117285167 @default.
- W1990506571 cites W2122366463 @default.
- W1990506571 cites W2131435922 @default.
- W1990506571 cites W2140066663 @default.
- W1990506571 cites W2143323131 @default.
- W1990506571 cites W2148255040 @default.
- W1990506571 cites W2149764521 @default.
- W1990506571 cites W2154022519 @default.
- W1990506571 cites W2154793195 @default.
- W1990506571 cites W2156253798 @default.
- W1990506571 cites W2166862366 @default.
- W1990506571 cites W2167379455 @default.
- W1990506571 doi "https://doi.org/10.1182/blood-2007-09-111179" @default.
- W1990506571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18223167" @default.
- W1990506571 hasPublicationYear "2008" @default.
- W1990506571 type Work @default.
- W1990506571 sameAs 1990506571 @default.
- W1990506571 citedByCount "51" @default.
- W1990506571 countsByYear W19905065712012 @default.
- W1990506571 countsByYear W19905065712013 @default.
- W1990506571 countsByYear W19905065712014 @default.
- W1990506571 countsByYear W19905065712015 @default.
- W1990506571 countsByYear W19905065712016 @default.
- W1990506571 countsByYear W19905065712017 @default.
- W1990506571 countsByYear W19905065712018 @default.
- W1990506571 countsByYear W19905065712019 @default.
- W1990506571 countsByYear W19905065712020 @default.
- W1990506571 countsByYear W19905065712021 @default.
- W1990506571 countsByYear W19905065712022 @default.
- W1990506571 countsByYear W19905065712023 @default.
- W1990506571 crossrefType "journal-article" @default.
- W1990506571 hasAuthorship W1990506571A5008677905 @default.
- W1990506571 hasAuthorship W1990506571A5036250119 @default.
- W1990506571 hasAuthorship W1990506571A5046604110 @default.
- W1990506571 hasAuthorship W1990506571A5053103217 @default.
- W1990506571 hasAuthorship W1990506571A5077618588 @default.
- W1990506571 hasAuthorship W1990506571A5086592087 @default.
- W1990506571 hasBestOaLocation W19905065711 @default.
- W1990506571 hasConcept C100701293 @default.
- W1990506571 hasConcept C154317977 @default.
- W1990506571 hasConcept C16224149 @default.
- W1990506571 hasConcept C170493617 @default.