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• W1990525150 startingPage "1386" @default.
• W1990525150 abstract "Acute aerobic exercise increases reactive oxygen species and could potentially damage proteins, but exercise training (ET) enhances mitochondrial respiration irrespective of age. Here, we report a differential impact of ET on protein quality in young and older participants. Using mass spectrometry we measured oxidative damage to skeletal muscle proteins before and after 8 weeks of ET and find that young but not older participants reduced oxidative damage to both total skeletal muscle and mitochondrial proteins. Young participants showed higher total and mitochondrial derived semitryptic peptides and 26S proteasome activity indicating increased protein degradation. ET however, increased the activity of the endogenous antioxidants in older participants. ET also increased skeletal muscle content of the mitochondrial deacetylase SIRT3 in both groups. A reduction in the acetylation of isocitrate dehydrogenase 2 was observed following ET that may counteract the effect of acute oxidative stress. In conclusion aging is associated with an inability to improve skeletal muscle and mitochondrial protein quality in response to ET by increasing degradation of damaged proteins. ET does however increase muscle and mitochondrial antioxidant capacity in older individuals, which provides increased buffering from the acute oxidative effects of exercise." @default.
• W1990525150 created "2016-06-24" @default.
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• W1990525150 date "2014-12-10" @default.
• W1990525150 modified "2023-09-27" @default.
• W1990525150 title "Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging" @default.
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• W1990525150 doi "https://doi.org/10.1093/gerona/glu221" @default.
• W1990525150 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4612384" @default.
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• W1990525150 hasPublicationYear "2014" @default.
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