FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990531444> ?p ?o ?g. }

• W1990531444 endingPage "669" @default.
• W1990531444 startingPage "659" @default.
• W1990531444 abstract "Acquired resistance to endocrine therapy in breast cancer is a major clinical problem. Previous reports have demonstrated that cell models of acquired endocrine resistance have altered cell–matrix adhesion and a highly migratory phenotype, features which may impact on tumour spread in vivo. Focal adhesion kinase (FAK) is an intracellular kinase that regulates signalling pathways central to cell adhesion, migration and survival and its expression is frequently deregulated in breast cancer. In this study, we have used the novel FAK inhibitor PF573228 to address the role of FAK in the development of endocrine resistance. Whilst total-FAK expression was similar between endocrine-sensitive and endocrine-resistant MCF7 cells, FAK phosphorylation status (Y397 or Y861) was altered in resistance. PF573228 promoted a dose-dependent inhibition of FAK phosphorylation at Y397 but did not affect other FAK activation sites (pY407, pY576 and pY861). Endocrine-resistant cells were more sensitive to these inhibitory effects versus MCF7 (mean IC50 for FAK pY397 inhibition: 0.43 μM, 0.05 μM and 0.13 μM for MCF7, TamR and FasR cells, respectively). Inhibition of FAK pY397 was associated with a reduction in TamR and FasR adhesion to, and migration over, matrix components. PF573228 as a single agent (0–1 μM) did not affect the growth of MCF7 cells or their endocrine-resistant counterparts. However, treatment of endocrine-sensitive cells with PF573228 and tamoxifen combined resulted in greater suppression of proliferation versus single agent treatment. Together these data suggest the importance of FAK in the process of endocrine resistance, particularly in the development of an aggressive, migratory cell phenotype and demonstrate the potential to improve endocrine response through combination treatment." @default.
• W1990531444 created "2016-06-24" @default.
• W1990531444 creator A5003969811 @default.
• W1990531444 creator A5007340763 @default.
• W1990531444 creator A5026707923 @default.
• W1990531444 creator A5029966106 @default.
• W1990531444 creator A5031404897 @default.
• W1990531444 creator A5074923974 @default.
• W1990531444 creator A5089244810 @default.
• W1990531444 date "2010-03-31" @default.
• W1990531444 modified "2023-10-10" @default.
• W1990531444 title "Inhibition of focal adhesion kinase suppresses the adverse phenotype of endocrine-resistant breast cancer cells and improves endocrine response in endocrine-sensitive cells" @default.
• W1990531444 cites W1512551807 @default.
• W1990531444 cites W1577573926 @default.
• W1990531444 cites W1964628210 @default.
• W1990531444 cites W1970392892 @default.
• W1990531444 cites W1971382968 @default.
• W1990531444 cites W1979067350 @default.
• W1990531444 cites W1981336142 @default.
• W1990531444 cites W1982287353 @default.
• W1990531444 cites W1982533191 @default.
• W1990531444 cites W1991830395 @default.
• W1990531444 cites W1999247203 @default.
• W1990531444 cites W2001999652 @default.
• W1990531444 cites W2002514277 @default.
• W1990531444 cites W2014007705 @default.
• W1990531444 cites W2016208891 @default.
• W1990531444 cites W2021683914 @default.
• W1990531444 cites W2025005089 @default.
• W1990531444 cites W2036931337 @default.
• W1990531444 cites W2039469642 @default.
• W1990531444 cites W2043065181 @default.
• W1990531444 cites W2044895919 @default.
• W1990531444 cites W2045394733 @default.
• W1990531444 cites W2045792003 @default.
• W1990531444 cites W2047765160 @default.
• W1990531444 cites W2048082956 @default.
• W1990531444 cites W2049761405 @default.
• W1990531444 cites W2053582875 @default.
• W1990531444 cites W2073907826 @default.
• W1990531444 cites W2082207901 @default.
• W1990531444 cites W2087305746 @default.
• W1990531444 cites W2088373022 @default.
• W1990531444 cites W2092023077 @default.
• W1990531444 cites W2096960044 @default.
• W1990531444 cites W2098837223 @default.
• W1990531444 cites W2105356859 @default.
• W1990531444 cites W2106404417 @default.
• W1990531444 cites W2124565099 @default.
• W1990531444 cites W2125501362 @default.
• W1990531444 cites W2128701004 @default.
• W1990531444 cites W2132739803 @default.
• W1990531444 cites W2135891897 @default.
• W1990531444 cites W2136655476 @default.
• W1990531444 cites W2142042013 @default.
• W1990531444 cites W2153390917 @default.
• W1990531444 cites W2155372340 @default.
• W1990531444 cites W2156609440 @default.
• W1990531444 cites W2158769524 @default.
• W1990531444 cites W2159695799 @default.
• W1990531444 cites W2164017897 @default.
• W1990531444 cites W2310034942 @default.
• W1990531444 cites W2312739661 @default.
• W1990531444 cites W4240458298 @default.
• W1990531444 cites W4249092084 @default.
• W1990531444 doi "https://doi.org/10.1007/s10549-010-0857-4" @default.
• W1990531444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20354780" @default.
• W1990531444 hasPublicationYear "2010" @default.
• W1990531444 type Work @default.
• W1990531444 sameAs 1990531444 @default.
• W1990531444 citedByCount "35" @default.
• W1990531444 countsByYear W19905314442012 @default.
• W1990531444 countsByYear W19905314442013 @default.
• W1990531444 countsByYear W19905314442014 @default.
• W1990531444 countsByYear W19905314442015 @default.
• W1990531444 countsByYear W19905314442016 @default.
• W1990531444 countsByYear W19905314442017 @default.
• W1990531444 countsByYear W19905314442018 @default.
• W1990531444 countsByYear W19905314442019 @default.
• W1990531444 countsByYear W19905314442020 @default.
• W1990531444 countsByYear W19905314442021 @default.
• W1990531444 countsByYear W19905314442022 @default.
• W1990531444 countsByYear W19905314442023 @default.
• W1990531444 crossrefType "journal-article" @default.
• W1990531444 hasAuthorship W1990531444A5003969811 @default.
• W1990531444 hasAuthorship W1990531444A5007340763 @default.
• W1990531444 hasAuthorship W1990531444A5026707923 @default.
• W1990531444 hasAuthorship W1990531444A5029966106 @default.
• W1990531444 hasAuthorship W1990531444A5031404897 @default.
• W1990531444 hasAuthorship W1990531444A5074923974 @default.
• W1990531444 hasAuthorship W1990531444A5089244810 @default.
• W1990531444 hasBestOaLocation W19905314442 @default.
• W1990531444 hasConcept C121608353 @default.
• W1990531444 hasConcept C126322002 @default.
• W1990531444 hasConcept C134018914 @default.
• W1990531444 hasConcept C1491633281 @default.
• W1990531444 hasConcept C151166631 @default.
• W1990531444 hasConcept C184235292 @default.

• next