FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990532388> ?p ?o ?g. }

• W1990532388 endingPage "107" @default.
• W1990532388 startingPage "97" @default.
• W1990532388 abstract "An in situ versus in vitro comparison of relative dose-dependent effects of halothane on cardiac performance was investigated, including ventricular systolic/diastolic function. Such comparative studies may be of interest to individuals working on heart failure models, cardiac device testing, or xenotransplantation. Normal swine (n=9) received halothane at levels of 0.25, 0.5 and 1 MAC (minimum alveolar concentration) for 30 min each. Parameters assessed included: 1) heart rate; 2) arterial blood pressure; 3) pulmonary artery, central venous, left and right ventricular pressures; 4) cardiac output; 5) end-expiratory CO(2) and halothane levels; 6) cardiac temperature; and 7) arterial blood gases. Hearts were removed using standard cardioplegic procedures and reperfused in four-chamber working mode (n=8); again the effects of increasing halothane concentrations on cardiac performance were analyzed. When comparing biventricular depressive effects (negative inotropic, negative lusitropic) of halothane in vivo and in vitro, there were distinct quantitative differences. The negative lusitropic effects were less pronounced in vitro; this was especially true for the right ventricle. Yet, in vitro, halothane at all doses induced more pronounced decreases in left heart output compared to the right. The large mammalian isolated four-chamber working heart model allows for novel assessment of pharmacodynamics and/or evaluation of cardiac devices under a range of hemodynamic performances. Halothane, a cardiodepressive agent, induced direct myocardial depressive effects in vitro similar to those recorded in vivo; hence additional systemic effects are considered to play a minor role in ultimate performances, e.g., compensatory responses due to autonomic controls." @default.
• W1990532388 created "2016-06-24" @default.
• W1990532388 creator A5038966090 @default.
• W1990532388 creator A5054407917 @default.
• W1990532388 date "2006-08-01" @default.
• W1990532388 modified "2023-09-25" @default.
• W1990532388 title "In vivo versus in vitro comparison of swine cardiac performance: Induction of cardiodepression with halothane" @default.
• W1990532388 cites W1525022792 @default.
• W1990532388 cites W1565403003 @default.
• W1990532388 cites W1964080270 @default.
• W1990532388 cites W1964847016 @default.
• W1990532388 cites W1967583996 @default.
• W1990532388 cites W1973924579 @default.
• W1990532388 cites W1976573128 @default.
• W1990532388 cites W1981614847 @default.
• W1990532388 cites W1989451611 @default.
• W1990532388 cites W2000061135 @default.
• W1990532388 cites W2005482527 @default.
• W1990532388 cites W2006595386 @default.
• W1990532388 cites W2010987262 @default.
• W1990532388 cites W2021420127 @default.
• W1990532388 cites W2026153417 @default.
• W1990532388 cites W2041809697 @default.
• W1990532388 cites W2045059130 @default.
• W1990532388 cites W2045495630 @default.
• W1990532388 cites W2047951898 @default.
• W1990532388 cites W2058317107 @default.
• W1990532388 cites W2071372645 @default.
• W1990532388 cites W2083550153 @default.
• W1990532388 cites W2083961812 @default.
• W1990532388 cites W2087217171 @default.
• W1990532388 cites W2091807643 @default.
• W1990532388 cites W2101050779 @default.
• W1990532388 cites W2106877565 @default.
• W1990532388 cites W2126511480 @default.
• W1990532388 cites W2131752095 @default.
• W1990532388 cites W2139931520 @default.
• W1990532388 cites W2150656743 @default.
• W1990532388 cites W2159677174 @default.
• W1990532388 cites W2164955412 @default.
• W1990532388 cites W2166081500 @default.
• W1990532388 cites W2166672918 @default.
• W1990532388 cites W2176987607 @default.
• W1990532388 cites W2243104838 @default.
• W1990532388 cites W2394847007 @default.
• W1990532388 cites W2412406166 @default.
• W1990532388 cites W2418111527 @default.
• W1990532388 doi "https://doi.org/10.1016/j.ejphar.2006.06.011" @default.
• W1990532388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16842774" @default.
• W1990532388 hasPublicationYear "2006" @default.
• W1990532388 type Work @default.
• W1990532388 sameAs 1990532388 @default.
• W1990532388 citedByCount "14" @default.
• W1990532388 countsByYear W19905323882013 @default.
• W1990532388 countsByYear W19905323882016 @default.
• W1990532388 countsByYear W19905323882017 @default.
• W1990532388 countsByYear W19905323882018 @default.
• W1990532388 countsByYear W19905323882019 @default.
• W1990532388 countsByYear W19905323882020 @default.
• W1990532388 countsByYear W19905323882023 @default.
• W1990532388 crossrefType "journal-article" @default.
• W1990532388 hasAuthorship W1990532388A5038966090 @default.
• W1990532388 hasAuthorship W1990532388A5054407917 @default.
• W1990532388 hasConcept C111566952 @default.
• W1990532388 hasConcept C126322002 @default.
• W1990532388 hasConcept C139940330 @default.
• W1990532388 hasConcept C150903083 @default.
• W1990532388 hasConcept C155710745 @default.
• W1990532388 hasConcept C158328960 @default.
• W1990532388 hasConcept C164705383 @default.
• W1990532388 hasConcept C178853913 @default.
• W1990532388 hasConcept C207001950 @default.
• W1990532388 hasConcept C2776932660 @default.
• W1990532388 hasConcept C2777953023 @default.
• W1990532388 hasConcept C2778198053 @default.
• W1990532388 hasConcept C2778921608 @default.
• W1990532388 hasConcept C42219234 @default.
• W1990532388 hasConcept C57900726 @default.
• W1990532388 hasConcept C68923441 @default.
• W1990532388 hasConcept C71924100 @default.
• W1990532388 hasConcept C84393581 @default.
• W1990532388 hasConcept C86803240 @default.
• W1990532388 hasConceptScore W1990532388C111566952 @default.
• W1990532388 hasConceptScore W1990532388C126322002 @default.
• W1990532388 hasConceptScore W1990532388C139940330 @default.
• W1990532388 hasConceptScore W1990532388C150903083 @default.
• W1990532388 hasConceptScore W1990532388C155710745 @default.
• W1990532388 hasConceptScore W1990532388C158328960 @default.
• W1990532388 hasConceptScore W1990532388C164705383 @default.
• W1990532388 hasConceptScore W1990532388C178853913 @default.
• W1990532388 hasConceptScore W1990532388C207001950 @default.
• W1990532388 hasConceptScore W1990532388C2776932660 @default.
• W1990532388 hasConceptScore W1990532388C2777953023 @default.
• W1990532388 hasConceptScore W1990532388C2778198053 @default.
• W1990532388 hasConceptScore W1990532388C2778921608 @default.
• W1990532388 hasConceptScore W1990532388C42219234 @default.
• W1990532388 hasConceptScore W1990532388C57900726 @default.
• W1990532388 hasConceptScore W1990532388C68923441 @default.

• next