FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990537251> ?p ?o ?g. }

• W1990537251 endingPage "798" @default.
• W1990537251 startingPage "785" @default.
• W1990537251 abstract "Gene regulatory networks (GRNs) play a central role in sustaining complex biological systems in cells. Although we can construct GRNs by integrating biological interactions that have been recorded in literature, they can include suspicious data and a lack of information. Therefore, there has been an urgent need for an approach by which the validity of constructed networks can be evaluated; simulation-based methods have been applied in which biological observational data are assimilated. However, these methods apply nonlinear models that require high computational power to evaluate even one network consisting of only several genes. Therefore, to explore candidate networks whose simulation models can better predict the data by modifying and extending literature-based GRNs, an efficient and versatile method is urgently required. We applied a combinatorial transcription model, which can represent combinatorial regulatory effects of genes, as a biological simulation model, to reproduce the dynamic behavior of gene expressions within a state space model. Under the model, we applied the unscented Kalman filter to obtain the approximate posterior probability distribution of the hidden state to efficiently estimate parameter values maximizing prediction ability for observational data by the EM-algorithm. Utilizing the method, we propose a novel algorithm to modify GRNs reported in the literature so that their simulation models become consistent with observed data. The effectiveness of our approach was validated through comparison analysis to the previous methods using synthetic networks. Finally, as an application example, a Kyoto Encyclopedia of Genes and Genomes (KEGG)-based yeast cell cycle network was extended with additional candidate genes to better predict the real mRNA expressions data using the proposed method." @default.
• W1990537251 created "2016-06-24" @default.
• W1990537251 creator A5014697662 @default.
• W1990537251 creator A5016330265 @default.
• W1990537251 creator A5036953695 @default.
• W1990537251 creator A5071376729 @default.
• W1990537251 creator A5078146127 @default.
• W1990537251 creator A5090788230 @default.
• W1990537251 date "2014-11-01" @default.
• W1990537251 modified "2023-10-03" @default.
• W1990537251 title "An Efficient Data Assimilation Schema for Restoration and Extension of Gene Regulatory Networks Using Time-Course Observation Data" @default.
• W1990537251 cites W1553971664 @default.
• W1990537251 cites W1581582023 @default.
• W1990537251 cites W1994900200 @default.
• W1990537251 cites W1996804115 @default.
• W1990537251 cites W1998767819 @default.
• W1990537251 cites W2000040887 @default.
• W1990537251 cites W2011571266 @default.
• W1990537251 cites W2020934227 @default.
• W1990537251 cites W2034611068 @default.
• W1990537251 cites W2037799844 @default.
• W1990537251 cites W2044278781 @default.
• W1990537251 cites W2049633694 @default.
• W1990537251 cites W2086027516 @default.
• W1990537251 cites W2089062027 @default.
• W1990537251 cites W2101002710 @default.
• W1990537251 cites W2102221598 @default.
• W1990537251 cites W2103453943 @default.
• W1990537251 cites W2105934661 @default.
• W1990537251 cites W2107802551 @default.
• W1990537251 cites W2116018370 @default.
• W1990537251 cites W2121905499 @default.
• W1990537251 cites W2121990344 @default.
• W1990537251 cites W2123487311 @default.
• W1990537251 cites W2128292224 @default.
• W1990537251 cites W2132204276 @default.
• W1990537251 cites W2132555912 @default.
• W1990537251 cites W2134092975 @default.
• W1990537251 cites W2134312555 @default.
• W1990537251 cites W2142635246 @default.
• W1990537251 cites W2144227416 @default.
• W1990537251 cites W2144323650 @default.
• W1990537251 cites W2146506956 @default.
• W1990537251 cites W2148523353 @default.
• W1990537251 cites W2149135811 @default.
• W1990537251 cites W2154751475 @default.
• W1990537251 cites W2156435365 @default.
• W1990537251 cites W2157096295 @default.
• W1990537251 cites W2157826003 @default.
• W1990537251 cites W2168175751 @default.
• W1990537251 cites W2169765391 @default.
• W1990537251 cites W3149745985 @default.
• W1990537251 doi "https://doi.org/10.1089/cmb.2014.0171" @default.
• W1990537251 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4224052" @default.
• W1990537251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25244077" @default.
• W1990537251 hasPublicationYear "2014" @default.
• W1990537251 type Work @default.
• W1990537251 sameAs 1990537251 @default.
• W1990537251 citedByCount "3" @default.
• W1990537251 countsByYear W19905372512015 @default.
• W1990537251 countsByYear W19905372512017 @default.
• W1990537251 countsByYear W19905372512021 @default.
• W1990537251 crossrefType "journal-article" @default.
• W1990537251 hasAuthorship W1990537251A5014697662 @default.
• W1990537251 hasAuthorship W1990537251A5016330265 @default.
• W1990537251 hasAuthorship W1990537251A5036953695 @default.
• W1990537251 hasAuthorship W1990537251A5071376729 @default.
• W1990537251 hasAuthorship W1990537251A5078146127 @default.
• W1990537251 hasAuthorship W1990537251A5090788230 @default.
• W1990537251 hasBestOaLocation W19905372512 @default.
• W1990537251 hasConcept C104317684 @default.
• W1990537251 hasConcept C119857082 @default.
• W1990537251 hasConcept C121332964 @default.
• W1990537251 hasConcept C124101348 @default.
• W1990537251 hasConcept C150194340 @default.
• W1990537251 hasConcept C152662350 @default.
• W1990537251 hasConcept C153294291 @default.
• W1990537251 hasConcept C154945302 @default.
• W1990537251 hasConcept C201797286 @default.
• W1990537251 hasConcept C24552861 @default.
• W1990537251 hasConcept C41008148 @default.
• W1990537251 hasConcept C55493867 @default.
• W1990537251 hasConcept C60644358 @default.
• W1990537251 hasConcept C67339327 @default.
• W1990537251 hasConcept C70721500 @default.
• W1990537251 hasConcept C86803240 @default.
• W1990537251 hasConceptScore W1990537251C104317684 @default.
• W1990537251 hasConceptScore W1990537251C119857082 @default.
• W1990537251 hasConceptScore W1990537251C121332964 @default.
• W1990537251 hasConceptScore W1990537251C124101348 @default.
• W1990537251 hasConceptScore W1990537251C150194340 @default.
• W1990537251 hasConceptScore W1990537251C152662350 @default.
• W1990537251 hasConceptScore W1990537251C153294291 @default.
• W1990537251 hasConceptScore W1990537251C154945302 @default.
• W1990537251 hasConceptScore W1990537251C201797286 @default.
• W1990537251 hasConceptScore W1990537251C24552861 @default.
• W1990537251 hasConceptScore W1990537251C41008148 @default.
• W1990537251 hasConceptScore W1990537251C55493867 @default.

• next