FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990538908> ?p ?o ?g. }

• W1990538908 endingPage "e115488" @default.
• W1990538908 startingPage "e115488" @default.
• W1990538908 abstract "Immunoglobulin-like transcript (ILT) 3 and 4 are inhibitory receptors that modulate immune responses. Their expression has been reported to be affected by interferon, offering a possible mechanism by which this cytokine exerts its therapeutic effect in multiple sclerosis, a condition thought to involve excessive immune activity. To investigate this possibility, we measured expression of ILT3 and ILT4 on immune cells from multiple sclerosis patients, and in post-mortem brain tissue. We also studied the ability of interferon beta, alone or in combination with vitamin D, to induce upregulation of these receptors in vitro, and compared expression levels between interferon-treated and untreated multiple sclerosis patients. In vitro interferon beta treatment led to a robust upregulation of ILT3 and ILT4 on monocytes, and dihydroxyvitamin D3 increased expression of ILT3 but not ILT4. ILT3 was abundant in demyelinating lesions in postmortem brain, and expression on monocytes in the cerebrospinal fluid was higher than in peripheral blood, suggesting that the central nervous system milieu induces ILT3, or that ILT3 positive monocytes preferentially enter the brain. Our data are consistent with involvement of ILT3 and ILT4 in the modulation of immune responsiveness in multiple sclerosis by both interferon and vitamin D." @default.
• W1990538908 created "2016-06-24" @default.
• W1990538908 creator A5036652053 @default.
• W1990538908 creator A5037146165 @default.
• W1990538908 creator A5045351289 @default.
• W1990538908 creator A5055320315 @default.
• W1990538908 creator A5071258405 @default.
• W1990538908 creator A5071466585 @default.
• W1990538908 creator A5072901113 @default.
• W1990538908 creator A5076511422 @default.
• W1990538908 date "2014-12-31" @default.
• W1990538908 modified "2023-10-16" @default.
• W1990538908 title "Interferon Beta and Vitamin D Synergize to Induce Immunoregulatory Receptors on Peripheral Blood Monocytes of Multiple Sclerosis Patients" @default.
• W1990538908 cites W1484140899 @default.
• W1990538908 cites W1538563548 @default.
• W1990538908 cites W1570842557 @default.
• W1990538908 cites W1584051973 @default.
• W1990538908 cites W1604334489 @default.
• W1990538908 cites W1976983285 @default.
• W1990538908 cites W1981399050 @default.
• W1990538908 cites W1984401896 @default.
• W1990538908 cites W2008870899 @default.
• W1990538908 cites W2018249790 @default.
• W1990538908 cites W2022022565 @default.
• W1990538908 cites W2063516590 @default.
• W1990538908 cites W2069742840 @default.
• W1990538908 cites W2072448714 @default.
• W1990538908 cites W2097234404 @default.
• W1990538908 cites W2100412095 @default.
• W1990538908 cites W2100561704 @default.
• W1990538908 cites W2103252821 @default.
• W1990538908 cites W2107889871 @default.
• W1990538908 cites W2108448370 @default.
• W1990538908 cites W2109752085 @default.
• W1990538908 cites W2109978145 @default.
• W1990538908 cites W2110573501 @default.
• W1990538908 cites W2125384784 @default.
• W1990538908 cites W2144899382 @default.
• W1990538908 cites W2147579197 @default.
• W1990538908 cites W2147625687 @default.
• W1990538908 cites W2157569416 @default.
• W1990538908 cites W2159945795 @default.
• W1990538908 cites W2474662112 @default.
• W1990538908 cites W2916040650 @default.
• W1990538908 doi "https://doi.org/10.1371/journal.pone.0115488" @default.
• W1990538908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4281069" @default.
• W1990538908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25551576" @default.
• W1990538908 hasPublicationYear "2014" @default.
• W1990538908 type Work @default.
• W1990538908 sameAs 1990538908 @default.
• W1990538908 citedByCount "36" @default.
• W1990538908 countsByYear W19905389082015 @default.
• W1990538908 countsByYear W19905389082016 @default.
• W1990538908 countsByYear W19905389082017 @default.
• W1990538908 countsByYear W19905389082019 @default.
• W1990538908 countsByYear W19905389082020 @default.
• W1990538908 countsByYear W19905389082021 @default.
• W1990538908 countsByYear W19905389082022 @default.
• W1990538908 countsByYear W19905389082023 @default.
• W1990538908 crossrefType "journal-article" @default.
• W1990538908 hasAuthorship W1990538908A5036652053 @default.
• W1990538908 hasAuthorship W1990538908A5037146165 @default.
• W1990538908 hasAuthorship W1990538908A5045351289 @default.
• W1990538908 hasAuthorship W1990538908A5055320315 @default.
• W1990538908 hasAuthorship W1990538908A5071258405 @default.
• W1990538908 hasAuthorship W1990538908A5071466585 @default.
• W1990538908 hasAuthorship W1990538908A5072901113 @default.
• W1990538908 hasAuthorship W1990538908A5076511422 @default.
• W1990538908 hasBestOaLocation W19905389081 @default.
• W1990538908 hasConcept C104317684 @default.
• W1990538908 hasConcept C127561419 @default.
• W1990538908 hasConcept C203014093 @default.
• W1990538908 hasConcept C2776178377 @default.
• W1990538908 hasConcept C2778690821 @default.
• W1990538908 hasConcept C2780640218 @default.
• W1990538908 hasConcept C55493867 @default.
• W1990538908 hasConcept C71924100 @default.
• W1990538908 hasConcept C86803240 @default.
• W1990538908 hasConcept C8891405 @default.
• W1990538908 hasConceptScore W1990538908C104317684 @default.
• W1990538908 hasConceptScore W1990538908C127561419 @default.
• W1990538908 hasConceptScore W1990538908C203014093 @default.
• W1990538908 hasConceptScore W1990538908C2776178377 @default.
• W1990538908 hasConceptScore W1990538908C2778690821 @default.
• W1990538908 hasConceptScore W1990538908C2780640218 @default.
• W1990538908 hasConceptScore W1990538908C55493867 @default.
• W1990538908 hasConceptScore W1990538908C71924100 @default.
• W1990538908 hasConceptScore W1990538908C86803240 @default.
• W1990538908 hasConceptScore W1990538908C8891405 @default.
• W1990538908 hasIssue "12" @default.
• W1990538908 hasLocation W19905389081 @default.
• W1990538908 hasLocation W19905389082 @default.
• W1990538908 hasLocation W19905389083 @default.
• W1990538908 hasLocation W19905389084 @default.
• W1990538908 hasLocation W19905389085 @default.
• W1990538908 hasLocation W19905389086 @default.
• W1990538908 hasLocation W19905389087 @default.
• W1990538908 hasOpenAccess W1990538908 @default.

• next