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- W1990539090 abstract "Sex differences in estrogen-induced progestin receptors have been described in specific regions of the rat brain. To determine if α1-neurotransmission plays a role in the expression of the sex differences in progestin receptor induction, the effects of the α1-antagonist, prazosin, on progestin binding in microdissected regions of the rat brain was determined. Adrenalectomized/gonadectomized male or female rats were administered various doses of estradiol benzoate (EB) in combination with prazosin. With all treatment paradigms, and in both sexes, no significant effect of prazosin treatment on progestin receptor levels was observed. These results are consistent with the idea that sex differences in the estrogen-induction of progestin receptors in the rat hypothalamus are not due to sex differences in the α1-adrenergic regulation of progestin receptor synthesis." @default.
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- W1990539090 date "1990-04-01" @default.
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- W1990539090 title "Prazosin treatment does not affect progestin receptor induction in microdissected regions of the rat hypothalamus" @default.
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- W1990539090 doi "https://doi.org/10.1016/0006-8993(90)90631-k" @default.
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