Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990545907> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W1990545907 endingPage "65" @default.
- W1990545907 startingPage "57" @default.
- W1990545907 abstract "Although combination chemotherapy has had some success in the treatment of metastatic tumors, the overall results remain unsatisfactory. One major reason for this is acquired or intrinsic drug resistance of tumor cells. Nevertheless, in the last few years many of the biochemical mechanisms of drug resistance have been elucidated, including alterations of membrane transport (3, 35), increased detoxification by increase in thiol metabolism (11, 41), altered enzyme activity (7, 9) and increased DNA-repair capacity (32). This has provided the basis for the development of drugs which can specifically interact with the cause of resistance and restore the sensitivity of the tumor cell (4, 26). Among many other drugs, dipyridamole has attracted interest because of its well characterized low toxicity and its known interaction with nucleoside transport and other critical cellular functions. This article reviews the available literature dealing with the modulation of cytotoxic drug actions by dipyridamole. Most of the work is still in a preclinical stage, but the first clinical experiences will also be discussed and possible applications of this drug for further clinical studies will be delineated." @default.
- W1990545907 created "2016-06-24" @default.
- W1990545907 creator A5018711955 @default.
- W1990545907 creator A5033999259 @default.
- W1990545907 creator A5049551730 @default.
- W1990545907 creator A5050929435 @default.
- W1990545907 creator A5074542184 @default.
- W1990545907 creator A5080736266 @default.
- W1990545907 date "1990-12-01" @default.
- W1990545907 modified "2023-09-27" @default.
- W1990545907 title "Modulation of cytotoxic drug activity by dipyridamole" @default.
- W1990545907 cites W1642115037 @default.
- W1990545907 cites W1974203483 @default.
- W1990545907 cites W1978512571 @default.
- W1990545907 cites W1996148628 @default.
- W1990545907 cites W1997231925 @default.
- W1990545907 cites W1998194920 @default.
- W1990545907 cites W2019566621 @default.
- W1990545907 cites W2032166380 @default.
- W1990545907 cites W2042367294 @default.
- W1990545907 cites W2060876849 @default.
- W1990545907 cites W2067416123 @default.
- W1990545907 cites W2264155967 @default.
- W1990545907 cites W2315951127 @default.
- W1990545907 cites W76315661 @default.
- W1990545907 doi "https://doi.org/10.1016/0305-7372(90)90017-a" @default.
- W1990545907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2092872" @default.
- W1990545907 hasPublicationYear "1990" @default.
- W1990545907 type Work @default.
- W1990545907 sameAs 1990545907 @default.
- W1990545907 citedByCount "5" @default.
- W1990545907 crossrefType "journal-article" @default.
- W1990545907 hasAuthorship W1990545907A5018711955 @default.
- W1990545907 hasAuthorship W1990545907A5033999259 @default.
- W1990545907 hasAuthorship W1990545907A5049551730 @default.
- W1990545907 hasAuthorship W1990545907A5050929435 @default.
- W1990545907 hasAuthorship W1990545907A5074542184 @default.
- W1990545907 hasAuthorship W1990545907A5080736266 @default.
- W1990545907 hasConcept C126322002 @default.
- W1990545907 hasConcept C143998085 @default.
- W1990545907 hasConcept C154317977 @default.
- W1990545907 hasConcept C185592680 @default.
- W1990545907 hasConcept C202751555 @default.
- W1990545907 hasConcept C2776890861 @default.
- W1990545907 hasConcept C2780035454 @default.
- W1990545907 hasConcept C55493867 @default.
- W1990545907 hasConcept C71924100 @default.
- W1990545907 hasConcept C98274493 @default.
- W1990545907 hasConceptScore W1990545907C126322002 @default.
- W1990545907 hasConceptScore W1990545907C143998085 @default.
- W1990545907 hasConceptScore W1990545907C154317977 @default.
- W1990545907 hasConceptScore W1990545907C185592680 @default.
- W1990545907 hasConceptScore W1990545907C202751555 @default.
- W1990545907 hasConceptScore W1990545907C2776890861 @default.
- W1990545907 hasConceptScore W1990545907C2780035454 @default.
- W1990545907 hasConceptScore W1990545907C55493867 @default.
- W1990545907 hasConceptScore W1990545907C71924100 @default.
- W1990545907 hasConceptScore W1990545907C98274493 @default.
- W1990545907 hasLocation W19905459071 @default.
- W1990545907 hasLocation W19905459072 @default.
- W1990545907 hasOpenAccess W1990545907 @default.
- W1990545907 hasPrimaryLocation W19905459071 @default.
- W1990545907 hasRelatedWork W1978107024 @default.
- W1990545907 hasRelatedWork W1980214792 @default.
- W1990545907 hasRelatedWork W2006105641 @default.
- W1990545907 hasRelatedWork W2055128222 @default.
- W1990545907 hasRelatedWork W2412642093 @default.
- W1990545907 hasRelatedWork W2426261983 @default.
- W1990545907 hasRelatedWork W2437895651 @default.
- W1990545907 hasRelatedWork W2586724005 @default.
- W1990545907 hasRelatedWork W4239546014 @default.
- W1990545907 hasRelatedWork W4246896749 @default.
- W1990545907 hasVolume "17" @default.
- W1990545907 isParatext "false" @default.
- W1990545907 isRetracted "false" @default.
- W1990545907 magId "1990545907" @default.
- W1990545907 workType "article" @default.