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- W1990552019 abstract "Abstract: Chagas disease, caused by Trypanosoma cruzi, affects several million people in Central and South America. About 30% of chronic patients develop cardiomyopathy probably caused by parasite persistence and/or autoimmunity. While several cross-reactive antibodies generated during mammal T. cruzi infection have been described, very few cross-reactive T cells have been identified. We performed adoptive transfer experiments of T cells isolated from chronically infected mice. The results showed the generation of cardiac pathology in the absence of parasites. We also transferred cross-reactive SAPA-specific T cells and observed unspecific alterations in heart repolarization, cardiac inflammatory infiltration, and tissue damage." @default.
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- W1990552019 date "2007-06-01" @default.
- W1990552019 modified "2023-10-16" @default.
- W1990552019 title "Role of Trypanosoma cruzi Autoreactive T Cells in the Generation of Cardiac Pathology" @default.
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- W1990552019 doi "https://doi.org/10.1196/annals.1381.046" @default.
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