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- W1990554343 abstract "Transient replication assays using Autographa californica multiple nucleopolyhedrovirus (AcMNPV) and Choristoneura fumiferana multiple nucleopolyhedrovirus (CfMNPV) genes suggested that the interactions between P143, the viral helicase and LEF-3, a ssDNA-binding protein, may represent virus species specificity determinants. P143 and LEF-3 are essential for DNA replication in these assays and together with IE-1, the major immediate-early transcription factor, may be part of the viral replisome. In the current report, a lef-3 / p143 double-knockout AcMNPV bacmid was constructed that was defective for viral DNA replication and late gene expression. When the homologous lef-3/p143 CfMNPV genes were introduced into this double-knockout bacmid, DNA replication was restored but the level of replication was lower, budded virus production was delayed, and the yields were reduced from those in an AcMNPV-rescue bacmid. These results suggest that to maximize virus replication, baculovirus replisome assembly and function requires protein–protein interactions between P143 and LEF-3, and other viral proteins." @default.
- W1990554343 created "2016-06-24" @default.
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- W1990554343 date "2012-02-01" @default.
- W1990554343 modified "2023-09-27" @default.
- W1990554343 title "Choristoneura fumiferana multiple nucleopolyhedrovirus LEF-3–P143 complex can complement DNA replication and budded virus in an AcMNPV LEF-3–P143 double knockout bacmid" @default.
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- W1990554343 doi "https://doi.org/10.1099/vir.0.036699-0" @default.
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