FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990557546> ?p ?o ?g. }

• W1990557546 endingPage "26" @default.
• W1990557546 startingPage "26" @default.
• W1990557546 abstract "The sequence of alterations in the concentration and composition of different plasma lipoproteins following alcohol intake is not known. We therefore monitored the concentrations of cholesterol, triglycerides, phospholipids, and proteins in the major lipoprotein fractions (VLDL, LDL, HDL2, and HDL3) in ten nonalcoholic healthy male volunteers who were given 5.5 g of alcohol per kilogram of body weight during 212days (a weekend). In addition, lipoprotein lipase activity was measured in post-heparin plasma and in adipose tissue and hepatic lipase activity was measured in post-heparin plasma before and after the experiment. In a separate control experiment, the same subjects received meals and liquids without alcohol. Blood alcohol levels remained below 1.5 g/L. Alcohol caused a progressive increase in the fasting VLDL triglyceride and phospholipid concentrations, both of which were doubled during the experiment (P < 0.001). In contrast, the VLDL cholesterol levels remained unchanged until the third morning, when there was a slight increase. The LDL triglyceride and phospholipid concentrations also rose without simultaneous changes in the LDL cholesterol concentration. Consistent with these changes, the HDL cholesterol concentration showed no response to alcohol during the experiment, but the HDL phospholipid level rose from 76 to 99 mg/dL (P < 0.001). This was reflected as an increase in the HDL2 concentration from 124 to 158 mg/dL (P < 0.01), whereas no change occurred in the HDL3 level. The increment of HDL2 concentration was due to a rise of its triglycerides, phospholipids, and apoproteins A-I and A-II but not to a rise of cholesterol. Thus, the VLDL, LDL and HDL2 fractions all became relatively depleted of cholesterol during alcohol intake. Alcohol potentiated the postprandial rise of plasma triglycerides with an increase in triglyceride concentrations in all lipoprotein fractions. During alcohol intake the HDL2 concentration increased postprandially (P < 0.05) whereas the HDL3 concentration decreased slightly, the fall being accounted for by a decrease in the HDL3 cholesterol level. The lipoprotein lipase activity of adipose tissue increased by an average of 2.3-fold (P < 0.01) over the alcohol-intake period, whereas the postheparin plasma hepatic lipase activity fell by 28% (P < 0.01). The results support the hypothesis that alcohol initially stimulates the secretion of VLDL particles that contain less cholesterol than “normal” VLDL. As a consequence of this and of a concomitant induction of lipoprotein lipase, alcohol intake is followed by an accelerated transfer of the VLDL catabolic products to HDL and by a subsequent rise in the levels of HDL2 triglycerides, phospholipids, and apoproteins but not of cholesterol. The suppression of hepatic lipase activity by alcohol may contribute further to the rise of HDL2 phospholipids. It thus appears that the increase of HDL cholesterol is a late phenomenon being expressed only after more prolonged use of alcohol." @default.
• W1990557546 created "2016-06-24" @default.
• W1990557546 creator A5006707474 @default.
• W1990557546 creator A5022753899 @default.
• W1990557546 creator A5023868440 @default.
• W1990557546 creator A5037693396 @default.
• W1990557546 creator A5042619536 @default.
• W1990557546 creator A5044397575 @default.
• W1990557546 creator A5051311666 @default.
• W1990557546 creator A5074061558 @default.
• W1990557546 date "2007-06-01" @default.
• W1990557546 modified "2023-09-26" @default.
• W1990557546 title "PO2-30 APO A-I ISOFORMS DISPLAY DIFFERENT EFFICIENCIES IN INDUCING ABCA1-DEPENDENT CHOLESTEROL EFFLUX FROM MOUSE PERITONEAL MACROPHAGES" @default.
• W1990557546 doi "https://doi.org/10.1016/s1567-5688(07)71040-1" @default.
• W1990557546 hasPublicationYear "2007" @default.
• W1990557546 type Work @default.
• W1990557546 sameAs 1990557546 @default.
• W1990557546 citedByCount "0" @default.
• W1990557546 crossrefType "journal-article" @default.
• W1990557546 hasAuthorship W1990557546A5006707474 @default.
• W1990557546 hasAuthorship W1990557546A5022753899 @default.
• W1990557546 hasAuthorship W1990557546A5023868440 @default.
• W1990557546 hasAuthorship W1990557546A5037693396 @default.
• W1990557546 hasAuthorship W1990557546A5042619536 @default.
• W1990557546 hasAuthorship W1990557546A5044397575 @default.
• W1990557546 hasAuthorship W1990557546A5051311666 @default.
• W1990557546 hasAuthorship W1990557546A5074061558 @default.
• W1990557546 hasConcept C126322002 @default.
• W1990557546 hasConcept C134018914 @default.
• W1990557546 hasConcept C171089720 @default.
• W1990557546 hasConcept C185592680 @default.
• W1990557546 hasConcept C2778163477 @default.
• W1990557546 hasConcept C2778913445 @default.
• W1990557546 hasConcept C2778918659 @default.
• W1990557546 hasConcept C2780072125 @default.
• W1990557546 hasConcept C2780716463 @default.
• W1990557546 hasConcept C2781066024 @default.
• W1990557546 hasConcept C41625074 @default.
• W1990557546 hasConcept C55493867 @default.
• W1990557546 hasConcept C71924100 @default.
• W1990557546 hasConcept C8243546 @default.
• W1990557546 hasConcept C94879076 @default.
• W1990557546 hasConceptScore W1990557546C126322002 @default.
• W1990557546 hasConceptScore W1990557546C134018914 @default.
• W1990557546 hasConceptScore W1990557546C171089720 @default.
• W1990557546 hasConceptScore W1990557546C185592680 @default.
• W1990557546 hasConceptScore W1990557546C2778163477 @default.
• W1990557546 hasConceptScore W1990557546C2778913445 @default.
• W1990557546 hasConceptScore W1990557546C2778918659 @default.
• W1990557546 hasConceptScore W1990557546C2780072125 @default.
• W1990557546 hasConceptScore W1990557546C2780716463 @default.
• W1990557546 hasConceptScore W1990557546C2781066024 @default.
• W1990557546 hasConceptScore W1990557546C41625074 @default.
• W1990557546 hasConceptScore W1990557546C55493867 @default.
• W1990557546 hasConceptScore W1990557546C71924100 @default.
• W1990557546 hasConceptScore W1990557546C8243546 @default.
• W1990557546 hasConceptScore W1990557546C94879076 @default.
• W1990557546 hasIssue "1" @default.
• W1990557546 hasLocation W19905575461 @default.
• W1990557546 hasOpenAccess W1990557546 @default.
• W1990557546 hasPrimaryLocation W19905575461 @default.
• W1990557546 hasRelatedWork W1976602105 @default.
• W1990557546 hasRelatedWork W2020817737 @default.
• W1990557546 hasRelatedWork W2027942466 @default.
• W1990557546 hasRelatedWork W2036852488 @default.
• W1990557546 hasRelatedWork W2063385233 @default.
• W1990557546 hasRelatedWork W2068768710 @default.
• W1990557546 hasRelatedWork W2069315162 @default.
• W1990557546 hasRelatedWork W2144943167 @default.
• W1990557546 hasRelatedWork W2414850025 @default.
• W1990557546 hasRelatedWork W3147642398 @default.
• W1990557546 hasVolume "8" @default.
• W1990557546 isParatext "false" @default.
• W1990557546 isRetracted "false" @default.
• W1990557546 magId "1990557546" @default.
• W1990557546 workType "article" @default.