FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990562433> ?p ?o ?g. }

• W1990562433 endingPage "1674" @default.
• W1990562433 startingPage "1669" @default.
• W1990562433 abstract "Gastrin release by Helicobacter pylori may be an important step in the pathway leading to duodenal ulceration. A histamine H3-receptor agonist was found to release gastrin from antral mucosal fragments; this was interpreted as being due to suppression of somatostatin release. H. pylori is reported to produce Nalpha-methyl histamine (NalphaMH), which is an agonist of H3 as well as other histamine receptors. H. pylori infection also recruits mast cells, which release histamine.To determine the direct effects of histamine receptor agonists on isolated gastrin cells.Rabbit G-cells were prepared by countercurrent elutriation and cultured on 24-well plates.NalphaMH (10-6-10-4 M) caused a dose-dependent increase in gastrin release from a basal level of 2.3 +/- 0.2% total cell content (TCC; mean +/- S.E.M.) to a maximum of 5.1 +/- 0.7%, an increase of 117% (P < 0. 005) above basal. This was abolished by the H2-antagonist ranitidine (10-5 M), but not by immunoblockade with anti-somatostatin antibody, the H1-antagonist chlorpheniramine (10-5 M) or the H3-antagonist thioperamide (10-4 M). The histamine H2-receptor agonist dimaprit (10-6-10-4 M) increased gastrin release from 2.4 +/- 0.2% to 3.6 +/- 0.2% TCC (P < 0.001). Gastrin release was also stimulated by histamine (10-7-10-4 M) from a basal value of 3.0 +/- 0.3% to 5.4 +/- 0.5% TCC (P < 0.001). This also was inhibited by ranitidine (10-5 M) (P < 0.01).NalphaMH and histamine release gastrin from G-cells via H2-receptors; this might contribute to H. pylori-associated hypergastrinaemia." @default.
• W1990562433 created "2016-06-24" @default.
• W1990562433 creator A5003289895 @default.
• W1990562433 creator A5017795689 @default.
• W1990562433 creator A5030021416 @default.
• W1990562433 creator A5081812524 @default.
• W1990562433 date "1999-12-01" @default.
• W1990562433 modified "2023-09-23" @default.
• W1990562433 title "Nα-methyl histamine and histamine stimulate gastrin release from rabbit G-cells via histamine H2 -receptors" @default.
• W1990562433 cites W1258042975 @default.
• W1990562433 cites W1968615986 @default.
• W1990562433 cites W1970284682 @default.
• W1990562433 cites W1979273869 @default.
• W1990562433 cites W1989655056 @default.
• W1990562433 cites W1994527533 @default.
• W1990562433 cites W1997314459 @default.
• W1990562433 cites W1997828558 @default.
• W1990562433 cites W2003682437 @default.
• W1990562433 cites W2004573492 @default.
• W1990562433 cites W2005670414 @default.
• W1990562433 cites W2028322121 @default.
• W1990562433 cites W2033239938 @default.
• W1990562433 cites W2037187105 @default.
• W1990562433 cites W2046207475 @default.
• W1990562433 cites W2047693405 @default.
• W1990562433 cites W2047866172 @default.
• W1990562433 cites W2069439442 @default.
• W1990562433 cites W2076590654 @default.
• W1990562433 cites W2096370484 @default.
• W1990562433 cites W2104462181 @default.
• W1990562433 cites W2117884342 @default.
• W1990562433 cites W2126303703 @default.
• W1990562433 cites W2129962921 @default.
• W1990562433 cites W2135612996 @default.
• W1990562433 cites W2144157564 @default.
• W1990562433 cites W2334694428 @default.
• W1990562433 doi "https://doi.org/10.1046/j.1365-2036.1999.00649.x" @default.
• W1990562433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10594403" @default.
• W1990562433 hasPublicationYear "1999" @default.
• W1990562433 type Work @default.
• W1990562433 sameAs 1990562433 @default.
• W1990562433 citedByCount "23" @default.
• W1990562433 countsByYear W19905624332013 @default.
• W1990562433 countsByYear W19905624332016 @default.
• W1990562433 countsByYear W19905624332020 @default.
• W1990562433 crossrefType "journal-article" @default.
• W1990562433 hasAuthorship W1990562433A5003289895 @default.
• W1990562433 hasAuthorship W1990562433A5017795689 @default.
• W1990562433 hasAuthorship W1990562433A5030021416 @default.
• W1990562433 hasAuthorship W1990562433A5081812524 @default.
• W1990562433 hasConcept C10335311 @default.
• W1990562433 hasConcept C1122143 @default.
• W1990562433 hasConcept C119811328 @default.
• W1990562433 hasConcept C126322002 @default.
• W1990562433 hasConcept C134018914 @default.
• W1990562433 hasConcept C159545944 @default.
• W1990562433 hasConcept C170493617 @default.
• W1990562433 hasConcept C185592680 @default.
• W1990562433 hasConcept C2776166919 @default.
• W1990562433 hasConcept C2776297358 @default.
• W1990562433 hasConcept C2776885963 @default.
• W1990562433 hasConcept C2776986829 @default.
• W1990562433 hasConcept C2777445857 @default.
• W1990562433 hasConcept C2778938600 @default.
• W1990562433 hasConcept C2778997900 @default.
• W1990562433 hasConcept C30862142 @default.
• W1990562433 hasConcept C34400551 @default.
• W1990562433 hasConcept C49039625 @default.
• W1990562433 hasConcept C63180777 @default.
• W1990562433 hasConcept C71924100 @default.
• W1990562433 hasConcept C86803240 @default.
• W1990562433 hasConcept C98274493 @default.
• W1990562433 hasConceptScore W1990562433C10335311 @default.
• W1990562433 hasConceptScore W1990562433C1122143 @default.
• W1990562433 hasConceptScore W1990562433C119811328 @default.
• W1990562433 hasConceptScore W1990562433C126322002 @default.
• W1990562433 hasConceptScore W1990562433C134018914 @default.
• W1990562433 hasConceptScore W1990562433C159545944 @default.
• W1990562433 hasConceptScore W1990562433C170493617 @default.
• W1990562433 hasConceptScore W1990562433C185592680 @default.
• W1990562433 hasConceptScore W1990562433C2776166919 @default.
• W1990562433 hasConceptScore W1990562433C2776297358 @default.
• W1990562433 hasConceptScore W1990562433C2776885963 @default.
• W1990562433 hasConceptScore W1990562433C2776986829 @default.
• W1990562433 hasConceptScore W1990562433C2777445857 @default.
• W1990562433 hasConceptScore W1990562433C2778938600 @default.
• W1990562433 hasConceptScore W1990562433C2778997900 @default.
• W1990562433 hasConceptScore W1990562433C30862142 @default.
• W1990562433 hasConceptScore W1990562433C34400551 @default.
• W1990562433 hasConceptScore W1990562433C49039625 @default.
• W1990562433 hasConceptScore W1990562433C63180777 @default.
• W1990562433 hasConceptScore W1990562433C71924100 @default.
• W1990562433 hasConceptScore W1990562433C86803240 @default.
• W1990562433 hasConceptScore W1990562433C98274493 @default.
• W1990562433 hasIssue "12" @default.
• W1990562433 hasLocation W19905624331 @default.
• W1990562433 hasLocation W19905624332 @default.
• W1990562433 hasOpenAccess W1990562433 @default.

• next