Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990567927> ?p ?o ?g. }
- W1990567927 endingPage "545" @default.
- W1990567927 startingPage "526" @default.
- W1990567927 abstract "Erwinia carotovora produces the beta-lactam antibiotic, carbapenem, in response to a quorum sensing signalling molecule, N-(3-oxohexanoyl)-L-homoserine lactone (OHHL). We have mapped the OHHL-dependent promoter upstream of the first of the biosynthetic genes, carA. We have also analysed the effect on this promoter of the known genetic regulators of carbapenem expression, carR, carI (encoding homologues of LuxR and LuxI respectively) and hor (encoding a SlyA/MarR-like transcriptional regulator). We describe a previously unknown promoter located within the carA-H operon. This promoter does not respond to CarR and is required for quorum sensing-independent expression of the carbapenem resistance determinants encoded by the carFG genes. We have mapped the carR, carI and hor transcription start points, shown that CarR is positively autoregulated in the presence of OHHL, and have demonstrated negative feedback affecting transcription of carI. In addition, various environmental and physiological factors were shown to impinge on the transcription of the car biosynthetic genes. The nature of the carbon source and the temperature of growth influence carbapenem production by modulating the level of the OHHL signalling molecule, and thereby physiologically fine-tune the quorum sensing regulatory system." @default.
- W1990567927 created "2016-06-24" @default.
- W1990567927 creator A5020035912 @default.
- W1990567927 creator A5021735889 @default.
- W1990567927 creator A5025675232 @default.
- W1990567927 creator A5028972835 @default.
- W1990567927 creator A5033983285 @default.
- W1990567927 creator A5041851294 @default.
- W1990567927 creator A5042739196 @default.
- W1990567927 creator A5057438504 @default.
- W1990567927 creator A5077478992 @default.
- W1990567927 creator A5083225703 @default.
- W1990567927 date "2004-11-17" @default.
- W1990567927 modified "2023-10-03" @default.
- W1990567927 title "Carbapenem antibiotic biosynthesis in Erwinia carotovora is regulated by physiological and genetic factors modulating the quorum sensing-dependent control pathway" @default.
- W1990567927 cites W110302458 @default.
- W1990567927 cites W1540179470 @default.
- W1990567927 cites W1562974039 @default.
- W1990567927 cites W1565382580 @default.
- W1990567927 cites W1575706519 @default.
- W1990567927 cites W1605848192 @default.
- W1990567927 cites W1636002209 @default.
- W1990567927 cites W1851892282 @default.
- W1990567927 cites W1882810357 @default.
- W1990567927 cites W193267154 @default.
- W1990567927 cites W1933529100 @default.
- W1990567927 cites W1965232275 @default.
- W1990567927 cites W1974751723 @default.
- W1990567927 cites W2002637334 @default.
- W1990567927 cites W2003382195 @default.
- W1990567927 cites W2005394492 @default.
- W1990567927 cites W2007309583 @default.
- W1990567927 cites W2009663387 @default.
- W1990567927 cites W2013226839 @default.
- W1990567927 cites W2013349630 @default.
- W1990567927 cites W2018861183 @default.
- W1990567927 cites W2019891957 @default.
- W1990567927 cites W2020629169 @default.
- W1990567927 cites W2024967109 @default.
- W1990567927 cites W2028622989 @default.
- W1990567927 cites W2045991415 @default.
- W1990567927 cites W2061638026 @default.
- W1990567927 cites W2071424950 @default.
- W1990567927 cites W2078635599 @default.
- W1990567927 cites W2083761792 @default.
- W1990567927 cites W2084617901 @default.
- W1990567927 cites W2091331258 @default.
- W1990567927 cites W2112001696 @default.
- W1990567927 cites W2117714160 @default.
- W1990567927 cites W2127799152 @default.
- W1990567927 cites W2129623714 @default.
- W1990567927 cites W2137840411 @default.
- W1990567927 cites W2138802195 @default.
- W1990567927 cites W2141653906 @default.
- W1990567927 cites W2143417865 @default.
- W1990567927 cites W2144150209 @default.
- W1990567927 cites W2148922163 @default.
- W1990567927 doi "https://doi.org/10.1111/j.1365-2958.2004.04397.x" @default.
- W1990567927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15659168" @default.
- W1990567927 hasPublicationYear "2004" @default.
- W1990567927 type Work @default.
- W1990567927 sameAs 1990567927 @default.
- W1990567927 citedByCount "67" @default.
- W1990567927 countsByYear W19905679272012 @default.
- W1990567927 countsByYear W19905679272013 @default.
- W1990567927 countsByYear W19905679272014 @default.
- W1990567927 countsByYear W19905679272015 @default.
- W1990567927 countsByYear W19905679272016 @default.
- W1990567927 countsByYear W19905679272017 @default.
- W1990567927 countsByYear W19905679272018 @default.
- W1990567927 countsByYear W19905679272019 @default.
- W1990567927 countsByYear W19905679272020 @default.
- W1990567927 countsByYear W19905679272021 @default.
- W1990567927 countsByYear W19905679272022 @default.
- W1990567927 crossrefType "journal-article" @default.
- W1990567927 hasAuthorship W1990567927A5020035912 @default.
- W1990567927 hasAuthorship W1990567927A5021735889 @default.
- W1990567927 hasAuthorship W1990567927A5025675232 @default.
- W1990567927 hasAuthorship W1990567927A5028972835 @default.
- W1990567927 hasAuthorship W1990567927A5033983285 @default.
- W1990567927 hasAuthorship W1990567927A5041851294 @default.
- W1990567927 hasAuthorship W1990567927A5042739196 @default.
- W1990567927 hasAuthorship W1990567927A5057438504 @default.
- W1990567927 hasAuthorship W1990567927A5077478992 @default.
- W1990567927 hasAuthorship W1990567927A5083225703 @default.
- W1990567927 hasBestOaLocation W19905679271 @default.
- W1990567927 hasConcept C101762097 @default.
- W1990567927 hasConcept C104317684 @default.
- W1990567927 hasConcept C118687296 @default.
- W1990567927 hasConcept C138885662 @default.
- W1990567927 hasConcept C150194340 @default.
- W1990567927 hasConcept C179926584 @default.
- W1990567927 hasConcept C203075996 @default.
- W1990567927 hasConcept C27153228 @default.
- W1990567927 hasConcept C2778495000 @default.
- W1990567927 hasConcept C2779840497 @default.
- W1990567927 hasConcept C41895202 @default.
- W1990567927 hasConcept C54355233 @default.