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- W1990571456 abstract "The adenosine receptor system has been attributed with a broad range of both physiological and so-called 'retaliatory' functions in the heart and vessels. Despite many years of research, the precise roles of adenosine within the cardiovascular system continue to be debated, and new functions are continually emerging. Adenosine acts via 4 known G-protein-coupled receptor (GPCR) sub-types: A(1), A(2A), A(2B), and A(3) adenosine receptors (ARs). In addition to roles in cardiovascular control, these receptors may represent therapeutic targets, having been attributed with roles in modifying cell death and injury, inflammatory processes, and cardiac and vascular remodeling during/after ischemic or hypoxic insult. A number of models have been developed in which AR sub-types and adenosine handling enzymes have been genetically deleted or transgenically overexpressed in an attempt to more equivocally identify the regulatory functions of these proteins, to identify their potential value as therapeutic targets, and to uncover new regulatory functions of this receptor family. Findings generally support current dogma regarding cardioprotection via A(1) and A(3)ARs, and coronary vasoregulation via A(2)AR sub-types. However, some outcomes are both novel and controversial. This review outlines AR-modified murine models currently under study from the perspective of cardiovascular phenotype." @default.
- W1990571456 created "2016-06-24" @default.
- W1990571456 creator A5004008884 @default.
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- W1990571456 creator A5070127090 @default.
- W1990571456 creator A5085172858 @default.
- W1990571456 date "2007-04-01" @default.
- W1990571456 modified "2023-10-17" @default.
- W1990571456 title "Genetic modulation of adenosine receptor function and adenosine handling in murine hearts: Insights and issues" @default.
- W1990571456 cites W1521659744 @default.
- W1990571456 cites W1969091201 @default.
- W1990571456 cites W1969997616 @default.
- W1990571456 cites W1970929783 @default.
- W1990571456 cites W1971381575 @default.
- W1990571456 cites W1973160550 @default.
- W1990571456 cites W1973828522 @default.
- W1990571456 cites W1974833836 @default.
- W1990571456 cites W1975614861 @default.
- W1990571456 cites W1977722024 @default.
- W1990571456 cites W1977966461 @default.
- W1990571456 cites W1978029732 @default.
- W1990571456 cites W1981103601 @default.
- W1990571456 cites W1981527120 @default.
- W1990571456 cites W1985598247 @default.
- W1990571456 cites W1986161535 @default.
- W1990571456 cites W1988684746 @default.
- W1990571456 cites W1989197835 @default.
- W1990571456 cites W1989788293 @default.
- W1990571456 cites W1990089807 @default.
- W1990571456 cites W1990867939 @default.
- W1990571456 cites W1991058406 @default.
- W1990571456 cites W1992331073 @default.
- W1990571456 cites W1993088160 @default.
- W1990571456 cites W1993934320 @default.
- W1990571456 cites W1994378950 @default.
- W1990571456 cites W1995941325 @default.
- W1990571456 cites W1997370446 @default.
- W1990571456 cites W1997931717 @default.
- W1990571456 cites W1998447852 @default.
- W1990571456 cites W2004204424 @default.
- W1990571456 cites W2005223768 @default.
- W1990571456 cites W2006138005 @default.
- W1990571456 cites W2006489146 @default.
- W1990571456 cites W2006662480 @default.
- W1990571456 cites W2008088846 @default.
- W1990571456 cites W2008952071 @default.
- W1990571456 cites W2010512593 @default.
- W1990571456 cites W2011204280 @default.
- W1990571456 cites W2013217473 @default.
- W1990571456 cites W2019527305 @default.
- W1990571456 cites W2020168868 @default.
- W1990571456 cites W2021112309 @default.
- W1990571456 cites W2021474050 @default.
- W1990571456 cites W2024786162 @default.
- W1990571456 cites W2026046981 @default.
- W1990571456 cites W2028475894 @default.
- W1990571456 cites W2029490679 @default.
- W1990571456 cites W2030586784 @default.
- W1990571456 cites W2034082628 @default.
- W1990571456 cites W2034175553 @default.
- W1990571456 cites W2035064097 @default.
- W1990571456 cites W2036771366 @default.
- W1990571456 cites W2037407888 @default.
- W1990571456 cites W2040015354 @default.
- W1990571456 cites W2040164212 @default.
- W1990571456 cites W2044596153 @default.
- W1990571456 cites W2044767394 @default.
- W1990571456 cites W2045692189 @default.
- W1990571456 cites W2046302537 @default.
- W1990571456 cites W2046467234 @default.
- W1990571456 cites W2048579126 @default.
- W1990571456 cites W2048946830 @default.
- W1990571456 cites W2049149064 @default.
- W1990571456 cites W2052290396 @default.
- W1990571456 cites W2054906104 @default.
- W1990571456 cites W2055330376 @default.
- W1990571456 cites W2065075422 @default.
- W1990571456 cites W2067991846 @default.
- W1990571456 cites W2069446636 @default.
- W1990571456 cites W2073400284 @default.
- W1990571456 cites W2076415090 @default.
- W1990571456 cites W2077119701 @default.
- W1990571456 cites W2077259639 @default.
- W1990571456 cites W2077747679 @default.
- W1990571456 cites W2078529338 @default.
- W1990571456 cites W2079844789 @default.
- W1990571456 cites W2084839593 @default.
- W1990571456 cites W2086541144 @default.
- W1990571456 cites W2086807993 @default.
- W1990571456 cites W2089431920 @default.
- W1990571456 cites W2094319340 @default.
- W1990571456 cites W2096712970 @default.
- W1990571456 cites W2100770234 @default.
- W1990571456 cites W2103984309 @default.
- W1990571456 cites W2105064443 @default.
- W1990571456 cites W2105096908 @default.