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- W1990574098 abstract "Abstract. The structure-function relationship of human PTH was studied by testing the effects of its synthetic analogues on cAMP production in cultures of rat and human renal cortical cells. The human cell system was by two orders more sensitive to an agonist, hPTH 1-34, than the rat cell system. In both culture systems, Tyr 34 hPTH3-34NH 2 , which by itself had no influence on adenylate cyclase, caused approximately 90% inhibition of the hPTH 1-34-induced cAMP production at a molar ratio of 1000:1. On the other hand, Tyr 34 hPTH5-34NH 2 , Tyr 34 hPTH7-34NH 2 , Tyr 34 hPTH8-34NH 2 and Tyr 34 hPTH9-34NH 2 had weak but distinct agonist activity. When these four analogues were tested in the presence of hPTH 1-34, they acted as antagonists in the human cell system, whereas they still showed agonist activity in the rat cell system which was additive to that of hPTH 1-34. These data indicate that the amino acids at positions 1 and 2 of hPTH are important for its biological activity and that those in the sequence 9-34 also participate in the activation of adenylate cyclase. The higher sensitivity to hPTH 1-34 and the different response to some of the analogues of human renal cortical cells compared with rat renal cortical cells emphasize the importance of employing human cell systems in evaluating the structure-function relationship of hPTH." @default.
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- W1990574098 date "1988-08-01" @default.
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- W1990574098 title "Studies of structure-function relationship of human parathyroid hormone using rat and human renal cortical cells in culture" @default.
- W1990574098 doi "https://doi.org/10.1530/acta.0.1180551" @default.
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