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• W1990576487 abstract "Dietary cholesterol is important in the pathogenesis of atherosclerosis because of its strong influence in increasing the concentrations of plasma cholesterol and low-density lipoprotein (LDL). The cause and effect relationship of dietary cholesterol to atherosclerosis and plasma lipoproteins has been best demonstrated in the rhesus monkey: when fed dietary cholesterol, hypercholesterolemia, increased LDL, and later atherosclerosis and even myocardial infarction result. Significant regression of coronary atherosclerosis occurred when cholesterol was removed from the diet. Epidemiological observations throughout the world indicate a positive relationship between the amounts of dietary cholesterol and the mortality from coronary heart disease (CHD). In human beings, several dozen experiments show the strong influence of dietary cholesterol in increasing plasma cholesterol levels when the background diet is low in dietary cholesterol. The invariable result of dietary cholesterol feeding is an elevation of plasma cholesterol and LDL levels which occurs in normal subjects, in Tarahumara Indians, and in pregnant women, as well as in patients with a variety of hyperlipidemias. Even in outpatient studies conducted as a double-blind trial, dietary cholesterol had a hypercholesterolemic effect. However, in poorly controlled outpatient studies such effects have not always been demonstrated. Threshold and ceiling amounts for dietary cholesterol clearly exist for both animals and human beings. The threshold is that amount of dietary cholesterol which affects plasma cholesterol levels. As the quantity of cholesterol in the diet is gradually increased, the plasma cholesterol continues to rise until an apparent saturation point is reached. Thus, if one adds further large quantities of dietary cholesterol to an already cholesterol-rich diet, no further increase in plasma cholesterol concentrations will occur, because the ceiling has been exceeded. The “ceiling” explains why some experiments of dietary cholesterol feeding are negative." @default.
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• W1990576487 date "1983-01-01" @default.
• W1990576487 modified "2023-09-24" @default.
• W1990576487 title "The importance of dietary cholesterol in coronary heart disease" @default.
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• W1990576487 doi "https://doi.org/10.1016/0091-7435(83)90179-2" @default.
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