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• W1990581736 startingPage "354" @default.
• W1990581736 abstract "The UDP glucuronosyltransferases (UGT) of the gastrointestinal (GI) tract have a crucial role in protection against the toxic effects of lipophilic chemicals in the environment. UGTs such as UGT1A7, UGT1A8, and UGT1A10 are exclusively expressed in gastrointestinal tissues, each with a unique tissue distribution pattern that is subject to interindividual variation. The factors regulating this tissue-specific expression and that contribute to variability are beginning to be elucidated. Studies on the UGT1A7, 1A8, 1A9, and 1A10 gene promoters in Caco-2 cells, an in vitro model of enterocytes of the gastrointestinal tract, have identified the caudal homeodomain transcription factor, Cdx2, as an important regulator of the UGT1A8 and 1A10 gene proximal promoters. This transcription factor is found exclusively in the small intestine and colon: it is absent in the gastric epithelium and the esophagus. Cdx2 regulates the UGT1A8 and 1A10 promoters in cooperation with hepatocyte nuclear factor 1alpha (HNF1alpha). It is noteworthy that UGT1A7 is not expressed in gastrointestinal tissue distal to the gastric mucosa and does not contain a Cdx2 binding site in its proximal promoter. Transcription factors, including Sp1, which differentially bind to the initiator regions of the UGT1A8, 1A9, and 1A10 promoters, also contribute to the differences in expression of these UGTs in Caco-2 cells. The identification of important regulatory regions of UGT genes expressed in the gastrointestinal tract, and the transcription factors that bind to these regions, will aid in the elucidation of factors that contribute to interindividual differences in gastrointestinal UGT expression. In turn, this will lead to further understanding of interindividual variation in the capacity of the GI tract to metabolize lipophilic chemicals and to act as a barrier to dietary toxins and orally administered drugs." @default.
• W1990581736 created "2016-06-24" @default.
• W1990581736 creator A5005037223 @default.
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• W1990581736 creator A5076781787 @default.
• W1990581736 creator A5088715556 @default.
• W1990581736 date "2004-09-01" @default.
• W1990581736 modified "2023-10-17" @default.
• W1990581736 title "Regulation of UDP glucuronosyltransferases in the gastrointestinal tract" @default.
• W1990581736 cites W1486575517 @default.
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• W1990581736 cites W1559932979 @default.
• W1990581736 cites W1572023751 @default.
• W1990581736 cites W1577890972 @default.
• W1990581736 cites W1889149373 @default.
• W1990581736 cites W1900495311 @default.
• W1990581736 cites W1930861036 @default.
• W1990581736 cites W1941776068 @default.
• W1990581736 cites W1970086066 @default.
• W1990581736 cites W1973642609 @default.
• W1990581736 cites W1974655274 @default.
• W1990581736 cites W1979484497 @default.
• W1990581736 cites W1980094999 @default.
• W1990581736 cites W1982533604 @default.
• W1990581736 cites W1983039505 @default.
• W1990581736 cites W1994056027 @default.
• W1990581736 cites W1995727180 @default.
• W1990581736 cites W1996632591 @default.
• W1990581736 cites W2002673669 @default.
• W1990581736 cites W2006616124 @default.
• W1990581736 cites W2013331009 @default.
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• W1990581736 cites W2030868542 @default.
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• W1990581736 cites W2038608511 @default.
• W1990581736 cites W2039332514 @default.
• W1990581736 cites W2046215289 @default.
• W1990581736 cites W2050895147 @default.
• W1990581736 cites W2051849529 @default.
• W1990581736 cites W2054810829 @default.
• W1990581736 cites W2063839576 @default.
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• W1990581736 cites W2084010007 @default.
• W1990581736 cites W2087212443 @default.
• W1990581736 cites W2090299518 @default.
• W1990581736 cites W2092778704 @default.
• W1990581736 cites W2093539123 @default.
• W1990581736 cites W2095708925 @default.
• W1990581736 cites W2098668343 @default.
• W1990581736 cites W2105054943 @default.
• W1990581736 cites W2106983211 @default.
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• W1990581736 cites W2113712263 @default.
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• W1990581736 cites W2140054248 @default.
• W1990581736 cites W2142558285 @default.
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• W1990581736 doi "https://doi.org/10.1016/j.taap.2004.01.008" @default.
• W1990581736 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15364550" @default.
• W1990581736 hasPublicationYear "2004" @default.
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