Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990588718> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W1990588718 endingPage "196" @default.
- W1990588718 startingPage "189" @default.
- W1990588718 abstract "Microbiochemical assays of the proteoglycan and collagen content of articular cartilage and synovial lining have been performed on tissue sections taken from rabbits with antigen-induced arthritis. This experimental arthritis is a close analogue of the natural disease-rheumatoid arthritis. Animals were killed at intervals during the first 21 days following induction of arthritis to assess changes in the composition of the extracellular matrices of the synovial lining and articular cartilage during the early development of this experimental lesion. In confirmation of earlier studies these microbiochemical assays revealed a rapid and significant loss of proteoglycan from the articular cartilage. This loss was, however, not uniform but was restricted to the intermediate zone of the cartilage. Over the period studied, there was only a slight loss of proteoglycan from the superficial zone of the cartilage facing the joint cavity. These findings demonstrate that, at least in this model, cartilage proteoglycan loss is not due to the action of proteases present in the synovial fluid. Moreover it suggests that the chondrocytes in the mid-zone of the cartilage are responsive to those signals stimulating proteoglycan breakdown. There was no significant loss of collagen from the cartilage over the time period of this study. The synovial lining from arthritic joints, in contrast, showed a progressive increase in both proteoglycan and collagen." @default.
- W1990588718 created "2016-06-24" @default.
- W1990588718 creator A5015635846 @default.
- W1990588718 creator A5015677991 @default.
- W1990588718 creator A5063065323 @default.
- W1990588718 creator A5078390502 @default.
- W1990588718 date "1992-06-01" @default.
- W1990588718 modified "2023-10-16" @default.
- W1990588718 title "Microbiochemical Analysis of Changes in Proteoglycan and Collagen in Joint Tissues During the Development of Antigen-induced Arthritis in the Rabbit" @default.
- W1990588718 cites W1978060210 @default.
- W1990588718 cites W1979233010 @default.
- W1990588718 cites W1980978904 @default.
- W1990588718 cites W2007812932 @default.
- W1990588718 cites W2039707020 @default.
- W1990588718 cites W2044543233 @default.
- W1990588718 cites W2054679021 @default.
- W1990588718 cites W2064291141 @default.
- W1990588718 cites W2077083595 @default.
- W1990588718 cites W2092573313 @default.
- W1990588718 cites W2136960669 @default.
- W1990588718 cites W2145864210 @default.
- W1990588718 doi "https://doi.org/10.1016/s0934-8832(11)80061-2" @default.
- W1990588718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1383680" @default.
- W1990588718 hasPublicationYear "1992" @default.
- W1990588718 type Work @default.
- W1990588718 sameAs 1990588718 @default.
- W1990588718 citedByCount "9" @default.
- W1990588718 countsByYear W19905887182012 @default.
- W1990588718 countsByYear W19905887182015 @default.
- W1990588718 crossrefType "journal-article" @default.
- W1990588718 hasAuthorship W1990588718A5015635846 @default.
- W1990588718 hasAuthorship W1990588718A5015677991 @default.
- W1990588718 hasAuthorship W1990588718A5063065323 @default.
- W1990588718 hasAuthorship W1990588718A5078390502 @default.
- W1990588718 hasConcept C105702510 @default.
- W1990588718 hasConcept C142724271 @default.
- W1990588718 hasConcept C185592680 @default.
- W1990588718 hasConcept C189165786 @default.
- W1990588718 hasConcept C203014093 @default.
- W1990588718 hasConcept C204787440 @default.
- W1990588718 hasConcept C2776164576 @default.
- W1990588718 hasConcept C2776268809 @default.
- W1990588718 hasConcept C2777077863 @default.
- W1990588718 hasConcept C2777575956 @default.
- W1990588718 hasConcept C2779335624 @default.
- W1990588718 hasConcept C2779663596 @default.
- W1990588718 hasConcept C2780550940 @default.
- W1990588718 hasConcept C3020332539 @default.
- W1990588718 hasConcept C55493867 @default.
- W1990588718 hasConcept C71924100 @default.
- W1990588718 hasConceptScore W1990588718C105702510 @default.
- W1990588718 hasConceptScore W1990588718C142724271 @default.
- W1990588718 hasConceptScore W1990588718C185592680 @default.
- W1990588718 hasConceptScore W1990588718C189165786 @default.
- W1990588718 hasConceptScore W1990588718C203014093 @default.
- W1990588718 hasConceptScore W1990588718C204787440 @default.
- W1990588718 hasConceptScore W1990588718C2776164576 @default.
- W1990588718 hasConceptScore W1990588718C2776268809 @default.
- W1990588718 hasConceptScore W1990588718C2777077863 @default.
- W1990588718 hasConceptScore W1990588718C2777575956 @default.
- W1990588718 hasConceptScore W1990588718C2779335624 @default.
- W1990588718 hasConceptScore W1990588718C2779663596 @default.
- W1990588718 hasConceptScore W1990588718C2780550940 @default.
- W1990588718 hasConceptScore W1990588718C3020332539 @default.
- W1990588718 hasConceptScore W1990588718C55493867 @default.
- W1990588718 hasConceptScore W1990588718C71924100 @default.
- W1990588718 hasIssue "3" @default.
- W1990588718 hasLocation W19905887181 @default.
- W1990588718 hasLocation W19905887182 @default.
- W1990588718 hasOpenAccess W1990588718 @default.
- W1990588718 hasPrimaryLocation W19905887181 @default.
- W1990588718 hasRelatedWork W1967635624 @default.
- W1990588718 hasRelatedWork W1978361227 @default.
- W1990588718 hasRelatedWork W1990588718 @default.
- W1990588718 hasRelatedWork W2036725076 @default.
- W1990588718 hasRelatedWork W2040709572 @default.
- W1990588718 hasRelatedWork W2090234863 @default.
- W1990588718 hasRelatedWork W2162075470 @default.
- W1990588718 hasRelatedWork W2165414533 @default.
- W1990588718 hasRelatedWork W2169032957 @default.
- W1990588718 hasRelatedWork W2934907658 @default.
- W1990588718 hasVolume "12" @default.
- W1990588718 isParatext "false" @default.
- W1990588718 isRetracted "false" @default.
- W1990588718 magId "1990588718" @default.
- W1990588718 workType "article" @default.