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• W1990593099 abstract "Genome-scale screens for intraviral and virus–host protein interactions and the analysis of literature-curated datasets are able to provide a novel, comprehensive perspective of viruses, and virus-infected cells. Until now, large-scale interaction screens were predominantly performed with the yeast-two-hybrid (Y2H) system; however, alternative high-throughput technologies detecting binary protein interactions or protein complexes have been developed. Although many of the previous studies suffer from a rather poor validation of the results and few biological implications, these technologies potentially lead to a plethora of novel hypotheses. Here, we will give an overview of current approaches and their technical limitations, present recent examples and novel developments." @default.
• W1990593099 created "2016-06-24" @default.
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• W1990593099 date "2009-08-01" @default.
• W1990593099 modified "2023-09-27" @default.
• W1990593099 title "Connecting viral with cellular interactomes" @default.
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• W1990593099 doi "https://doi.org/10.1016/j.mib.2009.06.004" @default.
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