Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990594815> ?p ?o ?g. }
- W1990594815 endingPage "142" @default.
- W1990594815 startingPage "137" @default.
- W1990594815 abstract "Long-echo (TR: 2000 ms, TE: 136 ms) proton MRS of the cerebral tissue in the vicinity to intracranial lesion was done in 15 patients, mainly with parenchymal brain tumors. Significant decrease of N-acetylaspartate (NAA) (P<0.001) and more frequent presence of lactate (P<0.01) comparing with distant normal white matter were found in the perilesional brain tissue. The level of NAA in the perilesional brain tissue had negative associations with presence of lactate in the lesion (P<0.05), excess of lactate in the lesion compared to perilesional brain (P<0.01), grade of the perilesional edema (P<0.01) and patient's age (P<0.05). Multivariate analysis disclosed that identification of lactate in the lesion is associated with lower relative NAA content in the perilesional brain tissue, independently on the presence or absence of any other factor, including brain edema (P<0.001). In patients with lobar lesions who had at least one epileptic seizure during course of their disease the relative NAA content in the perilesional brain was significantly lower, comparing with those who were seizure-free (P<0.05). Therefore, lactate diffused from the tumor, or other metabolites secreted by lactate-producing neoplasm, should be considered as important contributors to the neuronal dysfunction in the surrounding brain. Decrease of NAA in the vicinity to intracranial lesions may reflect neuronal alteration responsible for associated epilepsy." @default.
- W1990594815 created "2016-06-24" @default.
- W1990594815 creator A5003936044 @default.
- W1990594815 creator A5010549225 @default.
- W1990594815 creator A5021146440 @default.
- W1990594815 creator A5026818434 @default.
- W1990594815 creator A5041313850 @default.
- W1990594815 creator A5062983106 @default.
- W1990594815 creator A5089642215 @default.
- W1990594815 creator A5091094303 @default.
- W1990594815 creator A5091800232 @default.
- W1990594815 date "2005-02-01" @default.
- W1990594815 modified "2023-09-24" @default.
- W1990594815 title "Proton MRS of the peritumoral brain" @default.
- W1990594815 cites W1992514651 @default.
- W1990594815 cites W1999844745 @default.
- W1990594815 cites W2006858477 @default.
- W1990594815 cites W2021245153 @default.
- W1990594815 cites W2071314439 @default.
- W1990594815 cites W2076310654 @default.
- W1990594815 cites W2085259423 @default.
- W1990594815 cites W2086348410 @default.
- W1990594815 cites W2115306681 @default.
- W1990594815 cites W2116837209 @default.
- W1990594815 cites W2147406086 @default.
- W1990594815 cites W2159389626 @default.
- W1990594815 cites W2159829055 @default.
- W1990594815 cites W2315052252 @default.
- W1990594815 cites W4247444918 @default.
- W1990594815 doi "https://doi.org/10.1016/j.jns.2004.11.039" @default.
- W1990594815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15694194" @default.
- W1990594815 hasPublicationYear "2005" @default.
- W1990594815 type Work @default.
- W1990594815 sameAs 1990594815 @default.
- W1990594815 citedByCount "40" @default.
- W1990594815 countsByYear W19905948152012 @default.
- W1990594815 countsByYear W19905948152013 @default.
- W1990594815 countsByYear W19905948152014 @default.
- W1990594815 countsByYear W19905948152015 @default.
- W1990594815 countsByYear W19905948152016 @default.
- W1990594815 countsByYear W19905948152017 @default.
- W1990594815 countsByYear W19905948152018 @default.
- W1990594815 countsByYear W19905948152019 @default.
- W1990594815 countsByYear W19905948152020 @default.
- W1990594815 countsByYear W19905948152021 @default.
- W1990594815 countsByYear W19905948152022 @default.
- W1990594815 crossrefType "journal-article" @default.
- W1990594815 hasAuthorship W1990594815A5003936044 @default.
- W1990594815 hasAuthorship W1990594815A5010549225 @default.
- W1990594815 hasAuthorship W1990594815A5021146440 @default.
- W1990594815 hasAuthorship W1990594815A5026818434 @default.
- W1990594815 hasAuthorship W1990594815A5041313850 @default.
- W1990594815 hasAuthorship W1990594815A5062983106 @default.
- W1990594815 hasAuthorship W1990594815A5089642215 @default.
- W1990594815 hasAuthorship W1990594815A5091094303 @default.
- W1990594815 hasAuthorship W1990594815A5091800232 @default.
- W1990594815 hasConcept C118552586 @default.
- W1990594815 hasConcept C126322002 @default.
- W1990594815 hasConcept C126838900 @default.
- W1990594815 hasConcept C142724271 @default.
- W1990594815 hasConcept C143409427 @default.
- W1990594815 hasConcept C196822366 @default.
- W1990594815 hasConcept C2778186239 @default.
- W1990594815 hasConcept C2780886150 @default.
- W1990594815 hasConcept C2781156865 @default.
- W1990594815 hasConcept C2781192897 @default.
- W1990594815 hasConcept C2986936838 @default.
- W1990594815 hasConcept C71924100 @default.
- W1990594815 hasConceptScore W1990594815C118552586 @default.
- W1990594815 hasConceptScore W1990594815C126322002 @default.
- W1990594815 hasConceptScore W1990594815C126838900 @default.
- W1990594815 hasConceptScore W1990594815C142724271 @default.
- W1990594815 hasConceptScore W1990594815C143409427 @default.
- W1990594815 hasConceptScore W1990594815C196822366 @default.
- W1990594815 hasConceptScore W1990594815C2778186239 @default.
- W1990594815 hasConceptScore W1990594815C2780886150 @default.
- W1990594815 hasConceptScore W1990594815C2781156865 @default.
- W1990594815 hasConceptScore W1990594815C2781192897 @default.
- W1990594815 hasConceptScore W1990594815C2986936838 @default.
- W1990594815 hasConceptScore W1990594815C71924100 @default.
- W1990594815 hasFunder F4320325268 @default.
- W1990594815 hasIssue "2" @default.
- W1990594815 hasLocation W19905948151 @default.
- W1990594815 hasLocation W19905948152 @default.
- W1990594815 hasOpenAccess W1990594815 @default.
- W1990594815 hasPrimaryLocation W19905948151 @default.
- W1990594815 hasRelatedWork W1027849828 @default.
- W1990594815 hasRelatedWork W107117702 @default.
- W1990594815 hasRelatedWork W121204999 @default.
- W1990594815 hasRelatedWork W2003902517 @default.
- W1990594815 hasRelatedWork W2021061491 @default.
- W1990594815 hasRelatedWork W2025148611 @default.
- W1990594815 hasRelatedWork W2025840199 @default.
- W1990594815 hasRelatedWork W2081825579 @default.
- W1990594815 hasRelatedWork W2326837458 @default.
- W1990594815 hasRelatedWork W2955764567 @default.
- W1990594815 hasVolume "228" @default.
- W1990594815 isParatext "false" @default.