Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990596477> ?p ?o ?g. }
- W1990596477 endingPage "309" @default.
- W1990596477 startingPage "267" @default.
- W1990596477 abstract "The study of physicochemical parameters to correlate mathematically chemical structure with biological activity induced by sets of congeneric drugs is now generally referred to as QSAR (quantitative structure-activity relationships). The ways in which the QSAR paradigm are developing are becoming more varied and complex. Many kinds of parameters are under study in many different groups; various types of mathematical models have been proposed and are being evaluated. Drug researchers are turning more to enzyme modulation to control various biological processes. It is the study of enzyme-ligand reactions of enzymes whose x-ray crystallographic structure is known that affords us the means for developing a deeper understanding of QSAR and, at the same time, enhancing our ability to make drugs more selective for various forms of a given enzyme. The union of x-ray crystallography, moleculargraphics, and QSAR is one of the most exciting new areas of drug development. This report is an introduction to how QSAR is being used to gain insight into the interaction of drugs with macromolecules and macromolecular systems." @default.
- W1990596477 created "2016-06-24" @default.
- W1990596477 creator A5034168601 @default.
- W1990596477 date "1981-01-01" @default.
- W1990596477 modified "2023-09-24" @default.
- W1990596477 title "The physicochemical approach to drug design and discovery (QSAR)" @default.
- W1990596477 cites W1481466581 @default.
- W1990596477 cites W1558447132 @default.
- W1990596477 cites W157808733 @default.
- W1990596477 cites W1967019396 @default.
- W1990596477 cites W1974947009 @default.
- W1990596477 cites W1977242738 @default.
- W1990596477 cites W1978929645 @default.
- W1990596477 cites W1979376849 @default.
- W1990596477 cites W1986278041 @default.
- W1990596477 cites W1988912081 @default.
- W1990596477 cites W1989138544 @default.
- W1990596477 cites W1990401536 @default.
- W1990596477 cites W1992506319 @default.
- W1990596477 cites W1993866754 @default.
- W1990596477 cites W1994246907 @default.
- W1990596477 cites W1995142559 @default.
- W1990596477 cites W1996958413 @default.
- W1990596477 cites W1997044022 @default.
- W1990596477 cites W1999403581 @default.
- W1990596477 cites W2002863105 @default.
- W1990596477 cites W2003492423 @default.
- W1990596477 cites W2003974641 @default.
- W1990596477 cites W2008168927 @default.
- W1990596477 cites W2012268513 @default.
- W1990596477 cites W2013975194 @default.
- W1990596477 cites W2014582936 @default.
- W1990596477 cites W2015044060 @default.
- W1990596477 cites W2016883812 @default.
- W1990596477 cites W2018124270 @default.
- W1990596477 cites W2019076359 @default.
- W1990596477 cites W2020974576 @default.
- W1990596477 cites W2021505761 @default.
- W1990596477 cites W2022785950 @default.
- W1990596477 cites W2025431091 @default.
- W1990596477 cites W2025870765 @default.
- W1990596477 cites W2027597984 @default.
- W1990596477 cites W2029098089 @default.
- W1990596477 cites W2029455977 @default.
- W1990596477 cites W2031237950 @default.
- W1990596477 cites W2032056080 @default.
- W1990596477 cites W2033864773 @default.
- W1990596477 cites W2036792150 @default.
- W1990596477 cites W2037281743 @default.
- W1990596477 cites W2037925412 @default.
- W1990596477 cites W2041669321 @default.
- W1990596477 cites W2044466175 @default.
- W1990596477 cites W2044632012 @default.
- W1990596477 cites W2045005550 @default.
- W1990596477 cites W2045958448 @default.
- W1990596477 cites W2048067245 @default.
- W1990596477 cites W2051982513 @default.
- W1990596477 cites W2052064353 @default.
- W1990596477 cites W2052226480 @default.
- W1990596477 cites W2053406821 @default.
- W1990596477 cites W2058785875 @default.
- W1990596477 cites W2060143947 @default.
- W1990596477 cites W2062671151 @default.
- W1990596477 cites W2064875245 @default.
- W1990596477 cites W2065877713 @default.
- W1990596477 cites W2066092828 @default.
- W1990596477 cites W2067468321 @default.
- W1990596477 cites W2068537235 @default.
- W1990596477 cites W2071158076 @default.
- W1990596477 cites W2072194452 @default.
- W1990596477 cites W2076227819 @default.
- W1990596477 cites W2077408329 @default.
- W1990596477 cites W2079199763 @default.
- W1990596477 cites W2079319357 @default.
- W1990596477 cites W2087166555 @default.
- W1990596477 cites W2087465523 @default.
- W1990596477 cites W2089217030 @default.
- W1990596477 cites W2089648056 @default.
- W1990596477 cites W2090196650 @default.
- W1990596477 cites W2091128704 @default.
- W1990596477 cites W2091498408 @default.
- W1990596477 cites W2091702890 @default.
- W1990596477 cites W2106722078 @default.
- W1990596477 cites W2107748559 @default.
- W1990596477 cites W2152121191 @default.
- W1990596477 cites W2322193123 @default.
- W1990596477 cites W2323299231 @default.
- W1990596477 cites W2324334471 @default.
- W1990596477 cites W2328703415 @default.
- W1990596477 cites W2329777215 @default.
- W1990596477 cites W2331556649 @default.
- W1990596477 cites W2413882585 @default.
- W1990596477 cites W2413906779 @default.
- W1990596477 cites W2423210039 @default.
- W1990596477 cites W2495503024 @default.
- W1990596477 cites W2501343114 @default.
- W1990596477 cites W2503995074 @default.
- W1990596477 cites W2921122368 @default.