FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990606779> ?p ?o ?g. }

• W1990606779 endingPage "1101" @default.
• W1990606779 startingPage "1092" @default.
• W1990606779 abstract "The clinical and pathological features of classical Hodgkin lymphoma (cHL) mirror an abnormal tissue and systemic immune response due to the production of a variety of cytokines and chemokines by the malignant Hodgkin-Reed-Sternberg (H-RS) cells and/or surrounding reactive cells. Here, we demonstrate that HL-derived cell lines (L-428, KM-H2, HDLM-2, L-1236 and L-540) and primary H-RS cells from lymph node tissues of HL patients express the IL-7(R) receptor. IL-7 appears to be involved in autocrine circuitries of HL because L-1236, HDLM-2 and KM-H2 cells display the constitutive production of IL-7 and neutralizing anti-IL-7 antibodies induces a statistically significant inhibition of their basal proliferation. In addition, IL-7, either exogenous or fibroblasts-derived, promotes the clonogenic growth and reduces apoptosis of cultured H-RS cells, being also able to partially protect these cells from the cytotoxic effects of doxorubicin. We also provide evidence that IL-7 stimulates IL-6 secretion from IL-7R-expressing fibroblasts from HL-involved lymph nodes (HLFs), and that a striking increase in IL-6 secretion can be observed in cocultures of HLFs with L1236 cells. Finally, we show that L-1236 cells-derived IL-7 represents a costimulator for proliferation of purified CD4+CD25+CD127(dim/-) regulatory T cells (Tregs). Taken together, our data indicates that the IL-7/IL-7R axis constitutes an additional signaling pathway between H-RS cells and their reactive cellular background, thereby affecting proliferation and survival of tumor cells, acting as a cofactor for Tregs expansion and enhancing the microenviromental production of IL-6, a cytokine associated with the presence of B symptoms and a poor outcome in HL patients." @default.
• W1990606779 created "2016-06-24" @default.
• W1990606779 creator A5006278471 @default.
• W1990606779 creator A5008340388 @default.
• W1990606779 creator A5018141566 @default.
• W1990606779 creator A5018789268 @default.
• W1990606779 creator A5020652802 @default.
• W1990606779 creator A5033029228 @default.
• W1990606779 creator A5035514953 @default.
• W1990606779 creator A5045745778 @default.
• W1990606779 creator A5049075689 @default.
• W1990606779 creator A5061054780 @default.
• W1990606779 date "2009-04-23" @default.
• W1990606779 modified "2023-10-12" @default.
• W1990606779 title "Functional coexpression of Interleukin (IL)-7 and its receptor (IL-7R) on Hodgkin and Reed-Sternberg cells: Involvement of IL-7 in tumor cell growth and microenvironmental interactions of Hodgkin's lymphoma" @default.
• W1990606779 cites W141079059 @default.
• W1990606779 cites W1537534922 @default.
• W1990606779 cites W1559820769 @default.
• W1990606779 cites W1844161829 @default.
• W1990606779 cites W1970516837 @default.
• W1990606779 cites W1970796415 @default.
• W1990606779 cites W1972168709 @default.
• W1990606779 cites W1972725743 @default.
• W1990606779 cites W1982673084 @default.
• W1990606779 cites W1984976795 @default.
• W1990606779 cites W1986250542 @default.
• W1990606779 cites W2001709426 @default.
• W1990606779 cites W2001856947 @default.
• W1990606779 cites W2007998723 @default.
• W1990606779 cites W2013572792 @default.
• W1990606779 cites W2016190362 @default.
• W1990606779 cites W2016704490 @default.
• W1990606779 cites W2021932553 @default.
• W1990606779 cites W2024512241 @default.
• W1990606779 cites W2026496740 @default.
• W1990606779 cites W2030137474 @default.
• W1990606779 cites W2039130367 @default.
• W1990606779 cites W2045437721 @default.
• W1990606779 cites W2046783953 @default.
• W1990606779 cites W2049426330 @default.
• W1990606779 cites W2051043829 @default.
• W1990606779 cites W2064395958 @default.
• W1990606779 cites W2068521142 @default.
• W1990606779 cites W2069283686 @default.
• W1990606779 cites W2071858964 @default.
• W1990606779 cites W2080181628 @default.
• W1990606779 cites W2084579140 @default.
• W1990606779 cites W2090101693 @default.
• W1990606779 cites W2092901341 @default.
• W1990606779 cites W2094121173 @default.
• W1990606779 cites W2094592905 @default.
• W1990606779 cites W2094798767 @default.
• W1990606779 cites W2098776533 @default.
• W1990606779 cites W2102391679 @default.
• W1990606779 cites W2102517064 @default.
• W1990606779 cites W2107317733 @default.
• W1990606779 cites W2107336310 @default.
• W1990606779 cites W2108789329 @default.
• W1990606779 cites W2113625315 @default.
• W1990606779 cites W2114964305 @default.
• W1990606779 cites W2123362105 @default.
• W1990606779 cites W2128306838 @default.
• W1990606779 cites W2135820233 @default.
• W1990606779 cites W2140633375 @default.
• W1990606779 cites W2150678612 @default.
• W1990606779 cites W2156358796 @default.
• W1990606779 cites W2157235421 @default.
• W1990606779 cites W2162653211 @default.
• W1990606779 cites W2166086426 @default.
• W1990606779 cites W2171775292 @default.
• W1990606779 cites W2196576584 @default.
• W1990606779 cites W2270424042 @default.
• W1990606779 cites W2417033957 @default.
• W1990606779 cites W2587280416 @default.
• W1990606779 cites W3117022642 @default.
• W1990606779 doi "https://doi.org/10.1002/ijc.24389" @default.
• W1990606779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19391137" @default.
• W1990606779 hasPublicationYear "2009" @default.
• W1990606779 type Work @default.
• W1990606779 sameAs 1990606779 @default.
• W1990606779 citedByCount "95" @default.
• W1990606779 countsByYear W19906067792012 @default.
• W1990606779 countsByYear W19906067792013 @default.
• W1990606779 countsByYear W19906067792014 @default.
• W1990606779 countsByYear W19906067792015 @default.
• W1990606779 countsByYear W19906067792016 @default.
• W1990606779 countsByYear W19906067792017 @default.
• W1990606779 countsByYear W19906067792018 @default.
• W1990606779 countsByYear W19906067792019 @default.
• W1990606779 countsByYear W19906067792020 @default.
• W1990606779 countsByYear W19906067792021 @default.
• W1990606779 countsByYear W19906067792022 @default.
• W1990606779 countsByYear W19906067792023 @default.
• W1990606779 crossrefType "journal-article" @default.
• W1990606779 hasAuthorship W1990606779A5006278471 @default.
• W1990606779 hasAuthorship W1990606779A5008340388 @default.
• W1990606779 hasAuthorship W1990606779A5018141566 @default.
• W1990606779 hasAuthorship W1990606779A5018789268 @default.

• next