FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990607537> ?p ?o ?g. }

• W1990607537 endingPage "5686" @default.
• W1990607537 startingPage "5675" @default.
• W1990607537 abstract "Defective function of the von Hippel-Lindau (VHL) tumor suppressor ablates proteolytic regulation of hypoxia-inducible factor alpha subunits (HIF-1alpha and HIF-2alpha), leading to constitutive activation of hypoxia pathways in renal cell carcinoma (RCC). Here we report a comparative analysis of the functions of HIF-1alpha and HIF-2alpha in RCC and non-RCC cells. We demonstrate common patterns of HIF-alpha isoform transcriptional selectivity in VHL-defective RCC that show consistent and striking differences from patterns in other cell types. We also show that HIF-alpha isoforms display unexpected suppressive interactions in RCC cells, with enhanced expression of HIF-2alpha suppressing HIF-1alpha and vice-versa. In VHL-defective RCC cells, we demonstrate that the protumorigenic genes encoding cyclin D1, transforming growth factor alpha, and vascular endothelial growth factor respond specifically to HIF-2alpha and that the proapoptotic gene encoding BNip3 responds positively to HIF-1alpha and negatively to HIF-2alpha, indicating that HIF-1alpha and HIF-2alpha have contrasting properties in the biology of RCC. In keeping with this, HIF-alpha isoform-specific transcriptional selectivity was matched by differential effects on the growth of RCC as tumor xenografts, with HIF-1alpha retarding and HIF-2alpha enhancing tumor growth. These findings indicate that therapeutic approaches to targeting of the HIF system, at least in this setting, will need to take account of HIF isoform-specific functions." @default.
• W1990607537 created "2016-06-24" @default.
• W1990607537 creator A5018236839 @default.
• W1990607537 creator A5023595055 @default.
• W1990607537 creator A5031795710 @default.
• W1990607537 creator A5036848232 @default.
• W1990607537 creator A5043311300 @default.
• W1990607537 creator A5059128200 @default.
• W1990607537 creator A5064727417 @default.
• W1990607537 creator A5077279166 @default.
• W1990607537 creator A5079633934 @default.
• W1990607537 creator A5085665562 @default.
• W1990607537 date "2005-07-01" @default.
• W1990607537 modified "2023-10-10" @default.
• W1990607537 title "Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma" @default.
• W1990607537 cites W1481473039 @default.
• W1990607537 cites W1493048246 @default.
• W1990607537 cites W1543662618 @default.
• W1990607537 cites W1578283200 @default.
• W1990607537 cites W1624342207 @default.
• W1990607537 cites W1749022239 @default.
• W1990607537 cites W1844723954 @default.
• W1990607537 cites W1939179218 @default.
• W1990607537 cites W1950269610 @default.
• W1990607537 cites W1972032694 @default.
• W1990607537 cites W1977242675 @default.
• W1990607537 cites W1979083195 @default.
• W1990607537 cites W1989040551 @default.
• W1990607537 cites W1996715681 @default.
• W1990607537 cites W2011810742 @default.
• W1990607537 cites W2024064023 @default.
• W1990607537 cites W2029080338 @default.
• W1990607537 cites W2032491192 @default.
• W1990607537 cites W2034822725 @default.
• W1990607537 cites W2042702043 @default.
• W1990607537 cites W2060480804 @default.
• W1990607537 cites W2081460564 @default.
• W1990607537 cites W2089804952 @default.
• W1990607537 cites W2090090918 @default.
• W1990607537 cites W2093776019 @default.
• W1990607537 cites W2094242056 @default.
• W1990607537 cites W2098972920 @default.
• W1990607537 cites W2099791897 @default.
• W1990607537 cites W2101084498 @default.
• W1990607537 cites W2102476325 @default.
• W1990607537 cites W2108915544 @default.
• W1990607537 cites W2109086596 @default.
• W1990607537 cites W2109492293 @default.
• W1990607537 cites W2114702277 @default.
• W1990607537 cites W2120607554 @default.
• W1990607537 cites W2122535638 @default.
• W1990607537 cites W2125257427 @default.
• W1990607537 cites W2125724189 @default.
• W1990607537 cites W2127303778 @default.
• W1990607537 cites W2129621205 @default.
• W1990607537 cites W2130568284 @default.
• W1990607537 cites W2137371083 @default.
• W1990607537 cites W2143793112 @default.
• W1990607537 cites W2144243712 @default.
• W1990607537 cites W2144631109 @default.
• W1990607537 cites W2153771223 @default.
• W1990607537 cites W2161472946 @default.
• W1990607537 cites W2167786713 @default.
• W1990607537 cites W2580449060 @default.
• W1990607537 cites W2596045242 @default.
• W1990607537 cites W4214881295 @default.
• W1990607537 cites W4294718043 @default.
• W1990607537 doi "https://doi.org/10.1128/mcb.25.13.5675-5686.2005" @default.
• W1990607537 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1157001" @default.
• W1990607537 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15964822" @default.
• W1990607537 hasPublicationYear "2005" @default.
• W1990607537 type Work @default.
• W1990607537 sameAs 1990607537 @default.
• W1990607537 citedByCount "825" @default.
• W1990607537 countsByYear W19906075372012 @default.
• W1990607537 countsByYear W19906075372013 @default.
• W1990607537 countsByYear W19906075372014 @default.
• W1990607537 countsByYear W19906075372015 @default.
• W1990607537 countsByYear W19906075372016 @default.
• W1990607537 countsByYear W19906075372017 @default.
• W1990607537 countsByYear W19906075372018 @default.
• W1990607537 countsByYear W19906075372019 @default.
• W1990607537 countsByYear W19906075372020 @default.
• W1990607537 countsByYear W19906075372021 @default.
• W1990607537 countsByYear W19906075372022 @default.
• W1990607537 countsByYear W19906075372023 @default.
• W1990607537 crossrefType "journal-article" @default.
• W1990607537 hasAuthorship W1990607537A5018236839 @default.
• W1990607537 hasAuthorship W1990607537A5023595055 @default.
• W1990607537 hasAuthorship W1990607537A5031795710 @default.
• W1990607537 hasAuthorship W1990607537A5036848232 @default.
• W1990607537 hasAuthorship W1990607537A5043311300 @default.
• W1990607537 hasAuthorship W1990607537A5059128200 @default.
• W1990607537 hasAuthorship W1990607537A5064727417 @default.
• W1990607537 hasAuthorship W1990607537A5077279166 @default.
• W1990607537 hasAuthorship W1990607537A5079633934 @default.
• W1990607537 hasAuthorship W1990607537A5085665562 @default.
• W1990607537 hasBestOaLocation W19906075371 @default.

• next