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- W1990622149 abstract "Autophagy as a conserved degradation and recycling process in eukaryotic cells, occurs constitutively, but is induced by stress. A fine regulation of autophagy in space, time, and intensity is critical for maintaining normal energy homeostasis and metabolism, and to allow for its therapeutic modulation in various autophagy-related human diseases. Autophagy activity is regulated in both transcriptional and post-translational manners. In this review, we summarize the cytosolic regulation of autophagy via its molecular machinery, and nuclear regulation by transcription factors. Specifically, we consider Ume6-ATG8 and Pho23-ATG9 transcriptional regulation in detail, as examples of how nuclear transcription factors and cytosolic machinery cooperate to determine autophagosome size and number, which are the two main mechanistic factors through which autophagy activity is regulated." @default.
- W1990622149 created "2016-06-24" @default.
- W1990622149 creator A5056339500 @default.
- W1990622149 creator A5066515392 @default.
- W1990622149 date "2014-06-10" @default.
- W1990622149 modified "2023-09-29" @default.
- W1990622149 title "Regulation of autophagy: Modulation of the size and number of autophagosomes" @default.
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- W1990622149 doi "https://doi.org/10.1016/j.febslet.2014.06.015" @default.
- W1990622149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4118767" @default.
- W1990622149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24928445" @default.