Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990626688> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W1990626688 endingPage "55" @default.
- W1990626688 startingPage "43" @default.
- W1990626688 abstract "The effects of vinorelbine (VRL) on the circadian rhythms in body temperature and locomotor activity were investigated in unrestrained B6D2F1 mice implanted with radio-telemetry transmitters. A single intravenous VRL dose (24 or 12 mg/kg) was given at 7 h after light onset (HALO), a time of high VRL toxicity, and resulted in transient suppression of temperature and activity circadian rhythms in mice kept in light-dark (LD) 12h: 12h. Such suppression was dose-dependent. It occurred within 1-5 d after VRL dosing. Recovery of both rhythms was partially complete within 5 d following the high dose and within 2 or 3 d after the low dose and was not influenced by suppression of photoperiodic synchronization by housing in continuous darkness. Moreover, VRL induced a dose-dependent relative decrease in amplitude and phase shift of the temperature circadian rhythm. The mesor and amplitude of the activity rhythm were markedly reduced following the VRL administration. The relevance of VRL dosing time was studied in mice housed in LD 12h:12h. Vinorelbine was injected weekly (20 mg/kg/injection) for 3 wk at 6 or 18 HALO. Vinorelbine treatment ablated the rest-activity and temperature rhythms 3-6d after each dose, with fewer alterations after VRL dosing at 18 HALO compared to 6 HALO, especially for the body temperature rhythm. There was at least partial recovery 1 wk after dosing, suggesting the weekly schedule of drug treatment is acceptable for therapeutic purposes. Our findings demonstrate that VRL can transiently, yet profoundly, alter circadian clock function. Vinorelbine-induced circadian dysfunction may contribute to the toxicokinetics of this and possibly other anticancer drugs." @default.
- W1990626688 created "2016-06-24" @default.
- W1990626688 creator A5046705460 @default.
- W1990626688 creator A5059500096 @default.
- W1990626688 creator A5078259466 @default.
- W1990626688 date "2002-01-01" @default.
- W1990626688 modified "2023-09-26" @default.
- W1990626688 title "Pharmacological effects of vinorelbine on body temperature and locomotor activity circadian rhythms in mice" @default.
- W1990626688 cites W1516737592 @default.
- W1990626688 cites W1963918443 @default.
- W1990626688 cites W2012566411 @default.
- W1990626688 cites W2026902309 @default.
- W1990626688 cites W2071235967 @default.
- W1990626688 cites W2084699449 @default.
- W1990626688 cites W2099890761 @default.
- W1990626688 cites W2152486489 @default.
- W1990626688 cites W2167265027 @default.
- W1990626688 cites W2296279407 @default.
- W1990626688 cites W3027034641 @default.
- W1990626688 doi "https://doi.org/10.1081/cbi-120002591" @default.
- W1990626688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11962685" @default.
- W1990626688 hasPublicationYear "2002" @default.
- W1990626688 type Work @default.
- W1990626688 sameAs 1990626688 @default.
- W1990626688 citedByCount "25" @default.
- W1990626688 countsByYear W19906266882012 @default.
- W1990626688 countsByYear W19906266882013 @default.
- W1990626688 countsByYear W19906266882014 @default.
- W1990626688 countsByYear W19906266882017 @default.
- W1990626688 countsByYear W19906266882018 @default.
- W1990626688 countsByYear W19906266882019 @default.
- W1990626688 countsByYear W19906266882020 @default.
- W1990626688 countsByYear W19906266882022 @default.
- W1990626688 crossrefType "journal-article" @default.
- W1990626688 hasAuthorship W1990626688A5046705460 @default.
- W1990626688 hasAuthorship W1990626688A5059500096 @default.
- W1990626688 hasAuthorship W1990626688A5078259466 @default.
- W1990626688 hasConcept C121446783 @default.
- W1990626688 hasConcept C126322002 @default.
- W1990626688 hasConcept C134018914 @default.
- W1990626688 hasConcept C135343436 @default.
- W1990626688 hasConcept C2776694085 @default.
- W1990626688 hasConcept C2777288759 @default.
- W1990626688 hasConcept C2778239845 @default.
- W1990626688 hasConcept C2779027399 @default.
- W1990626688 hasConcept C2780350996 @default.
- W1990626688 hasConcept C38606739 @default.
- W1990626688 hasConcept C59822182 @default.
- W1990626688 hasConcept C71924100 @default.
- W1990626688 hasConcept C86803240 @default.
- W1990626688 hasConcept C98274493 @default.
- W1990626688 hasConceptScore W1990626688C121446783 @default.
- W1990626688 hasConceptScore W1990626688C126322002 @default.
- W1990626688 hasConceptScore W1990626688C134018914 @default.
- W1990626688 hasConceptScore W1990626688C135343436 @default.
- W1990626688 hasConceptScore W1990626688C2776694085 @default.
- W1990626688 hasConceptScore W1990626688C2777288759 @default.
- W1990626688 hasConceptScore W1990626688C2778239845 @default.
- W1990626688 hasConceptScore W1990626688C2779027399 @default.
- W1990626688 hasConceptScore W1990626688C2780350996 @default.
- W1990626688 hasConceptScore W1990626688C38606739 @default.
- W1990626688 hasConceptScore W1990626688C59822182 @default.
- W1990626688 hasConceptScore W1990626688C71924100 @default.
- W1990626688 hasConceptScore W1990626688C86803240 @default.
- W1990626688 hasConceptScore W1990626688C98274493 @default.
- W1990626688 hasIssue "1" @default.
- W1990626688 hasLocation W19906266881 @default.
- W1990626688 hasLocation W19906266882 @default.
- W1990626688 hasOpenAccess W1990626688 @default.
- W1990626688 hasPrimaryLocation W19906266881 @default.
- W1990626688 hasRelatedWork W1830412493 @default.
- W1990626688 hasRelatedWork W1964838049 @default.
- W1990626688 hasRelatedWork W1972296525 @default.
- W1990626688 hasRelatedWork W2007885546 @default.
- W1990626688 hasRelatedWork W2054591837 @default.
- W1990626688 hasRelatedWork W2066408171 @default.
- W1990626688 hasRelatedWork W2087567367 @default.
- W1990626688 hasRelatedWork W2093900634 @default.
- W1990626688 hasRelatedWork W2100686842 @default.
- W1990626688 hasRelatedWork W2187659234 @default.
- W1990626688 hasVolume "19" @default.
- W1990626688 isParatext "false" @default.
- W1990626688 isRetracted "false" @default.
- W1990626688 magId "1990626688" @default.
- W1990626688 workType "article" @default.