FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990634170> ?p ?o ?g. }

• W1990634170 endingPage "158" @default.
• W1990634170 startingPage "144" @default.
• W1990634170 abstract "Dioleoylphosphatidylethanolamine (DOPE)-containing liposomes that demonstrated pH-dependent release of their contents were stabilized in the bilayer form through the addition of a cleavable lipid derivative of polyethylene glycol (PEG) in which the PEG was attached to a lipid anchor via a disulfide linkage (mPEG-S-S-DSPE). Liposomes stabilized with either a non-cleavable PEG (mPEG-DSPE) or mPEG-S-S-DSPE retained an encapsulated dye at pH 5.5, but treatment at pH 5.5 of liposomes stabilized with mPEG-S-S-DSPE with either dithiothreitol or cell-free extracts caused contents release due to cleavage of the PEG chains and concomitant destabilization of the DOPE liposomes. While formulations loaded with doxorubicin (DXR) were stable in culture media, DXR was rapidly released in human plasma. pH-Sensitive liposomes, targeted to the CD19 epitope on B-lymphoma cells, showed enhanced DXR delivery into the nuclei of the target cells and increased cytotoxicity compared to non-pH-sensitive liposomes. Pharmacokinetic studies suggested that mPEG-S-S-DSPE was rapidly cleaved in circulation. In a murine model of B-cell lymphoma, the therapeutic efficacy of an anti-CD19-targeted pH-sensitive formulation was superior to that of a stable long-circulating formulation of targeted liposomes despite the more rapid drug release and clearance of the pH-sensitive formulation. These results suggest that targeted pH-sensitive formulations of drugs may be able to increase the therapeutic efficacy of entrapped drugs." @default.
• W1990634170 created "2016-06-24" @default.
• W1990634170 creator A5042245871 @default.
• W1990634170 creator A5057021485 @default.
• W1990634170 creator A5060557304 @default.
• W1990634170 creator A5081875683 @default.
• W1990634170 creator A5082783334 @default.
• W1990634170 date "2001-12-01" @default.
• W1990634170 modified "2023-10-03" @default.
• W1990634170 title "Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells" @default.
• W1990634170 cites W1483734912 @default.
• W1990634170 cites W1513897103 @default.
• W1990634170 cites W167632067 @default.
• W1990634170 cites W1963983068 @default.
• W1990634170 cites W1964671048 @default.
• W1990634170 cites W1974754453 @default.
• W1990634170 cites W1981057166 @default.
• W1990634170 cites W1982650996 @default.
• W1990634170 cites W1983671192 @default.
• W1990634170 cites W2003639620 @default.
• W1990634170 cites W2006437878 @default.
• W1990634170 cites W2012446208 @default.
• W1990634170 cites W2012619372 @default.
• W1990634170 cites W2034230043 @default.
• W1990634170 cites W2039350685 @default.
• W1990634170 cites W2045230140 @default.
• W1990634170 cites W2048237085 @default.
• W1990634170 cites W2054064585 @default.
• W1990634170 cites W2056488424 @default.
• W1990634170 cites W2056644518 @default.
• W1990634170 cites W2064100334 @default.
• W1990634170 cites W2065337815 @default.
• W1990634170 cites W2077389972 @default.
• W1990634170 cites W2078211781 @default.
• W1990634170 cites W2114918609 @default.
• W1990634170 cites W2129404315 @default.
• W1990634170 cites W2133756116 @default.
• W1990634170 cites W2137155864 @default.
• W1990634170 cites W2150332790 @default.
• W1990634170 cites W2150900264 @default.
• W1990634170 cites W2164227469 @default.
• W1990634170 cites W2502080880 @default.
• W1990634170 cites W39449442 @default.
• W1990634170 doi "https://doi.org/10.1016/s0005-2736(01)00409-6" @default.
• W1990634170 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11718670" @default.
• W1990634170 hasPublicationYear "2001" @default.
• W1990634170 type Work @default.
• W1990634170 sameAs 1990634170 @default.
• W1990634170 citedByCount "198" @default.
• W1990634170 countsByYear W19906341702012 @default.
• W1990634170 countsByYear W19906341702013 @default.
• W1990634170 countsByYear W19906341702014 @default.
• W1990634170 countsByYear W19906341702015 @default.
• W1990634170 countsByYear W19906341702016 @default.
• W1990634170 countsByYear W19906341702017 @default.
• W1990634170 countsByYear W19906341702018 @default.
• W1990634170 countsByYear W19906341702019 @default.
• W1990634170 countsByYear W19906341702020 @default.
• W1990634170 countsByYear W19906341702021 @default.
• W1990634170 countsByYear W19906341702022 @default.
• W1990634170 countsByYear W19906341702023 @default.
• W1990634170 crossrefType "journal-article" @default.
• W1990634170 hasAuthorship W1990634170A5042245871 @default.
• W1990634170 hasAuthorship W1990634170A5057021485 @default.
• W1990634170 hasAuthorship W1990634170A5060557304 @default.
• W1990634170 hasAuthorship W1990634170A5081875683 @default.
• W1990634170 hasAuthorship W1990634170A5082783334 @default.
• W1990634170 hasBestOaLocation W19906341701 @default.
• W1990634170 hasConcept C10138342 @default.
• W1990634170 hasConcept C109316439 @default.
• W1990634170 hasConcept C112705442 @default.
• W1990634170 hasConcept C12554922 @default.
• W1990634170 hasConcept C126511603 @default.
• W1990634170 hasConcept C13245373 @default.
• W1990634170 hasConcept C141071460 @default.
• W1990634170 hasConcept C162324750 @default.
• W1990634170 hasConcept C178790620 @default.
• W1990634170 hasConcept C185154212 @default.
• W1990634170 hasConcept C185592680 @default.
• W1990634170 hasConcept C202751555 @default.
• W1990634170 hasConcept C2776694085 @default.
• W1990634170 hasConcept C2776964284 @default.
• W1990634170 hasConcept C2779820397 @default.
• W1990634170 hasConcept C2781303535 @default.
• W1990634170 hasConcept C54400483 @default.
• W1990634170 hasConcept C55493867 @default.
• W1990634170 hasConcept C71924100 @default.
• W1990634170 hasConcept C86803240 @default.
• W1990634170 hasConcept C98274493 @default.
• W1990634170 hasConceptScore W1990634170C10138342 @default.
• W1990634170 hasConceptScore W1990634170C109316439 @default.
• W1990634170 hasConceptScore W1990634170C112705442 @default.
• W1990634170 hasConceptScore W1990634170C12554922 @default.
• W1990634170 hasConceptScore W1990634170C126511603 @default.
• W1990634170 hasConceptScore W1990634170C13245373 @default.
• W1990634170 hasConceptScore W1990634170C141071460 @default.
• W1990634170 hasConceptScore W1990634170C162324750 @default.
• W1990634170 hasConceptScore W1990634170C178790620 @default.

• next