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- W1990637114 abstract "Abnormal postprandial lipoproteins are associated with an increased risk for cardiovascular disease. Postprandial remnant lipoproteins were usually analyzed indirectly using retinyl esters (RE) as a chylomicron core label during an oral fat loading test. Apo B-100 containing VLDL remnants in addition to apo B-48 containing chylomicron remnants can also be directly quantified using the RLP-Cholesterol Immunoseparation Assay. This recently available method uses monoclonal antibodies to apo A-I and apo B-100 to remove non-remnant lipoproteins and quantifies cholesterol in the remaining apo E-rich remnant fraction. In the present study we compared the analysis of retinyl ester with the immuno-based RLP-Cholesterol (RLP-C) analysis in measuring postprandial remnant lipoproteins in healthy normolipidemic subjects. Sixteen healthy normolipidemic subjects were selected for this study. Postprandial plasma retinyl esters peaked at 5.0±1.2 h, whereas plasma RLP-C showed a peak significantly earlier (P<0.001) at 3.5±0.6 h. In comparison, postprandial plasma TG and FFA peaked at 3.3±1.1 h (P<0.005 compared to retinyl esters). In conclusion, levels of RLP-C changed, during the postprandial phase, in parallel with plasma TG and FFA concentrations and peaked significantly earlier than retinyl esters. Postprandial measurements of RLP-C can be considered as a fast alternative method for the more laborious retinyl-ester analysis in clinical studies." @default.
- W1990637114 created "2016-06-24" @default.
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- W1990637114 date "2006-01-01" @default.
- W1990637114 modified "2023-09-26" @default.
- W1990637114 title "Th-W58:2 Predicting lifetime risk for cardiovascular disease based on risk factor burden" @default.
- W1990637114 doi "https://doi.org/10.1016/s1567-5688(06)81930-6" @default.
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