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• W1990642743 abstract "The main goal of our study has been to analyze the efficiency of new anticancer drugs, specifically histone deacetylase inhibitors, in tumor cells bearing a multidrug resistance phenotype. We report that the histone deacetylase inhibitors, Trichostatin A and Suberoylanilide Hydroxamic Acid (SAHA), dramatically reduce cell viability and promote apoptosis in different drug-resistant cells, affecting in a much lesser extent to their parental drug-sensitive counterparts. The differential effects induced by Trichostatin A and SAHA between drug-sensitive and drug-resistant cells are reflected on the main characteristics of the resistant phenotype. Thus, reverse transcription-PCR and Western immunoblots confirm that both histone deacetylase inhibitors promote endogenous down-regulation of P-glycoprotein, which is overexpressed in the drug-resistant cells. Transfection of drug-sensitive cells with the P-glycoprotein cDNA ruled out the a priori possible association between apoptosis and down-regulation of P-glycoprotein induced by the histone deacetylase inhibitors. The results suggest a therapeutic potential of histone deacetylase inhibitors in the treatment of cancers with acquired resistance." @default.
• W1990642743 created "2016-06-24" @default.
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• W1990642743 date "2003-01-24" @default.
• W1990642743 modified "2023-10-14" @default.
• W1990642743 title "Susceptibility of multidrug resistance tumor cells to apoptosis induction by histone deacetylase inhibitors" @default.
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• W1990642743 doi "https://doi.org/10.1002/ijc.10998" @default.
• W1990642743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12594812" @default.
• W1990642743 hasPublicationYear "2003" @default.
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