FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990644512> ?p ?o ?g. }

• W1990644512 endingPage "181" @default.
• W1990644512 startingPage "173" @default.
• W1990644512 abstract "Atypical antipsychotic drugs (APDs) such as clozapine and olanzapine antagonize both D(1) and D(2) receptors; however, little is known regarding their pharmacologic effect on specific neuronal elements within the local circuitry of corticolimbic regions, such as medial prefrontal cortex (mPFC). To characterize the effect of short-term antagonism of the D(1) receptor a high-resolution autoradiographic technique was used to assess the density (B(max)) and affinity (K(d)) of this receptor on pyramidal cells (i.e., large neurons (LNs, >/=100 microm(2))), nonpyramidal cells (i.e., small neurons (SNs, <100 microm(2))) and in the surrounding neuropil (NPL) of layer VI in rat mPFC. Either normal saline or the selective D(1) antagonist SCH23390 (1.0 mg/kg/day) were administered for 48 h via Alzet osmotic pumps. Frozen sections were incubated in [(3)H]SCH23390 (1-8 nM) in the presence or absence of the competitive inhibitor SKF38393 (10 microM). A microscopic adaptation to Scatchard analysis revealed a significant increase (82%) in B(max) for neuronal cell bodies (P < 0.05), but not for neuropil of drug-treated animals. Further analysis indicated that the increase in B(max) was present on SNs (94%, P < 0.05), but not LNs in SCH23390-treated rats. In contrast, K(d) values for LNs, SNs, and NPL were not significantly altered by drug treatment. Since the vast majority of SNs are nonpyramidal in nature, short-term administration of a selective D(1) antagonist seems to be associated with a preferential upregulation of this receptor on interneurons. Overall, these results are consistent with the hypothesis that the mechanism of action of atypical antipsychotic medications involves changes in D(1) receptor activity associated with local circuit neurons in rat mPFC." @default.
• W1990644512 created "2016-06-24" @default.
• W1990644512 creator A5011694858 @default.
• W1990644512 creator A5035297430 @default.
• W1990644512 creator A5055853655 @default.
• W1990644512 date "2000-03-01" @default.
• W1990644512 modified "2023-09-28" @default.
• W1990644512 title "Acute administration of SCH23390 increases D1 receptors on nonpyramidal neurons in rat mPFC" @default.
• W1990644512 cites W1503918021 @default.
• W1990644512 cites W174392155 @default.
• W1990644512 cites W1884206649 @default.
• W1990644512 cites W1964063175 @default.
• W1990644512 cites W1965592767 @default.
• W1990644512 cites W1965668451 @default.
• W1990644512 cites W1973044530 @default.
• W1990644512 cites W1975285296 @default.
• W1990644512 cites W1979792701 @default.
• W1990644512 cites W1985517071 @default.
• W1990644512 cites W1987914734 @default.
• W1990644512 cites W1988858027 @default.
• W1990644512 cites W1990712459 @default.
• W1990644512 cites W1995816684 @default.
• W1990644512 cites W1999719004 @default.
• W1990644512 cites W2006865155 @default.
• W1990644512 cites W2008631499 @default.
• W1990644512 cites W2018882438 @default.
• W1990644512 cites W2023379737 @default.
• W1990644512 cites W2027829376 @default.
• W1990644512 cites W2029448535 @default.
• W1990644512 cites W2032257903 @default.
• W1990644512 cites W2034269648 @default.
• W1990644512 cites W2039646168 @default.
• W1990644512 cites W2040883320 @default.
• W1990644512 cites W2041020663 @default.
• W1990644512 cites W2041487100 @default.
• W1990644512 cites W2050580902 @default.
• W1990644512 cites W2052280773 @default.
• W1990644512 cites W2052847008 @default.
• W1990644512 cites W2054843129 @default.
• W1990644512 cites W2060745891 @default.
• W1990644512 cites W2065917785 @default.
• W1990644512 cites W2067838356 @default.
• W1990644512 cites W2068992981 @default.
• W1990644512 cites W2079625239 @default.
• W1990644512 cites W2079762885 @default.
• W1990644512 cites W2084007108 @default.
• W1990644512 cites W2090006102 @default.
• W1990644512 cites W2094140353 @default.
• W1990644512 cites W2103301663 @default.
• W1990644512 cites W2126680030 @default.
• W1990644512 cites W2134257939 @default.
• W1990644512 cites W2134661055 @default.
• W1990644512 cites W2140840822 @default.
• W1990644512 cites W2157656429 @default.
• W1990644512 cites W2400774357 @default.
• W1990644512 doi "https://doi.org/10.1002/(sici)1098-2396(20000301)35:3<173::aid-syn2>3.0.co;2-u" @default.
• W1990644512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10657024" @default.
• W1990644512 hasPublicationYear "2000" @default.
• W1990644512 type Work @default.
• W1990644512 sameAs 1990644512 @default.
• W1990644512 citedByCount "3" @default.
• W1990644512 crossrefType "journal-article" @default.
• W1990644512 hasAuthorship W1990644512A5011694858 @default.
• W1990644512 hasAuthorship W1990644512A5035297430 @default.
• W1990644512 hasAuthorship W1990644512A5055853655 @default.
• W1990644512 hasConcept C104317684 @default.
• W1990644512 hasConcept C118552586 @default.
• W1990644512 hasConcept C126322002 @default.
• W1990644512 hasConcept C127561419 @default.
• W1990644512 hasConcept C134018914 @default.
• W1990644512 hasConcept C169760540 @default.
• W1990644512 hasConcept C170493617 @default.
• W1990644512 hasConcept C185592680 @default.
• W1990644512 hasConcept C2776412080 @default.
• W1990644512 hasConcept C2776885963 @default.
• W1990644512 hasConcept C2777831001 @default.
• W1990644512 hasConcept C2778122271 @default.
• W1990644512 hasConcept C2780864610 @default.
• W1990644512 hasConcept C513476851 @default.
• W1990644512 hasConcept C529278444 @default.
• W1990644512 hasConcept C55493867 @default.
• W1990644512 hasConcept C71924100 @default.
• W1990644512 hasConcept C86803240 @default.
• W1990644512 hasConcept C98274493 @default.
• W1990644512 hasConceptScore W1990644512C104317684 @default.
• W1990644512 hasConceptScore W1990644512C118552586 @default.
• W1990644512 hasConceptScore W1990644512C126322002 @default.
• W1990644512 hasConceptScore W1990644512C127561419 @default.
• W1990644512 hasConceptScore W1990644512C134018914 @default.
• W1990644512 hasConceptScore W1990644512C169760540 @default.
• W1990644512 hasConceptScore W1990644512C170493617 @default.
• W1990644512 hasConceptScore W1990644512C185592680 @default.
• W1990644512 hasConceptScore W1990644512C2776412080 @default.
• W1990644512 hasConceptScore W1990644512C2776885963 @default.
• W1990644512 hasConceptScore W1990644512C2777831001 @default.
• W1990644512 hasConceptScore W1990644512C2778122271 @default.
• W1990644512 hasConceptScore W1990644512C2780864610 @default.
• W1990644512 hasConceptScore W1990644512C513476851 @default.

• next