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• W1990644839 endingPage "e3" @default.
• W1990644839 startingPage "e3" @default.
• W1990644839 abstract "Listeria monocytogenes causes invasive disease by crossing the intestinal epithelial barrier. This process depends on the interaction between the bacterial surface protein Internalin A and the host protein E-cadherin, located below the epithelial tight junctions at the lateral cell-to-cell contacts. We used polarized MDCK cells as a model epithelium to determine how L. monocytogenes breaches the tight junctions to gain access to this basolateral receptor protein. We determined that L. monocytogenes does not actively disrupt the tight junctions, but finds E-cadherin at a morphologically distinct subset of intercellular junctions. We identified these sites as naturally occurring regions where single senescent cells are expelled and detached from the epithelium by extrusion. The surrounding cells reorganize to form a multicellular junction that maintains epithelial continuity. We found that E-cadherin is transiently exposed to the lumenal surface at multicellular junctions during and after cell extrusion, and that L. monocytogenes takes advantage of junctional remodeling to adhere to and subsequently invade the epithelium. In intact epithelial monolayers, an anti-E-cadherin antibody specifically decorates multicellular junctions and blocks L. monocytogenes adhesion. Furthermore, an L. monocytogenes mutant in the Internalin A gene is completely deficient in attachment to the epithelial apical surface and is unable to invade. We hypothesized that L. monocytogenes utilizes analogous extrusion sites for epithelial invasion in vivo. By infecting rabbit ileal loops, we found that the junctions at the cell extrusion zone of villus tips are the specific target for L. monocytogenes adhesion and invasion. Thus, L. monocytogenes exploits the dynamic nature of epithelial renewal and junctional remodeling to breach the intestinal barrier." @default.
• W1990644839 created "2016-06-24" @default.
• W1990644839 creator A5019192377 @default.
• W1990644839 creator A5027993083 @default.
• W1990644839 creator A5078436996 @default.
• W1990644839 creator A5083137875 @default.
• W1990644839 date "2006-01-27" @default.
• W1990644839 modified "2023-09-27" @default.
• W1990644839 title "Listeria monocytogenes Invades the Epithelial Junctions at Sites of Cell Extrusion" @default.
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• W1990644839 doi "https://doi.org/10.1371/journal.ppat.0020003" @default.
• W1990644839 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1354196" @default.
• W1990644839 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16446782" @default.

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