Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990653227> ?p ?o ?g. }
- W1990653227 endingPage "580" @default.
- W1990653227 startingPage "571" @default.
- W1990653227 abstract "Idiopathic megacolon (IMC) is an intractable motility disorder in which chronic symptoms of colonic dysmotility appear with no mechanical cause. Although a pathological analysis is essential to understand the mechanism of IMC, no study has compared the histopathologic findings between dilated and non-dilated loops in IMC cases, and little is known about the proportion of each disease subtype.Fifty-three full-thickness samples (dilated loops, n = 31; non-dilated loops, n = 22) from 31 IMC cases and 16 samples (dilated loops; n = 8, non-dilated loops; n = 8) from eight controls were collected. All the samples were stained with hematoxylin-eosin (HE), Hu C/D antibody, and CD117 antibody to assess degenerative myopathy, degenerative neuropathy, inflammatory neuropathy, hypoganglionosis, and mesenchymopathy according to the London Classification. Findings of the dilated and non-dilated loop samples were compared, and the proportions of each subtype were analyzed.Based on a control study, <60 ganglion cells/cm was defined as hypoganglionosis in our series. Myopathy was observed in 11 patients (35.5%), neuropathy was in 19 patients (61.3%), and mesenchymopathy was in 10 patients (32.2%). An overlap between subtypes was observed in some cases. Surprisingly, the non-dilated loop samples exhibited very similar histopathologic abnormalities to those observed in the dilated loop samples in most cases.Our study is the first to compare the histopathologic findings between dilated and non-dilated loops in IMC patients. Histopathologic abnormalities precede the clinical manifestation of IMC, and may consequently lead to gradual colonic dilatation; however, detailed mechanism including dilation triggering factor needs further elucidation." @default.
- W1990653227 created "2016-06-24" @default.
- W1990653227 creator A5002514925 @default.
- W1990653227 creator A5008918211 @default.
- W1990653227 creator A5031629829 @default.
- W1990653227 creator A5036068231 @default.
- W1990653227 creator A5043593857 @default.
- W1990653227 creator A5062001972 @default.
- W1990653227 creator A5083345625 @default.
- W1990653227 date "2014-01-06" @default.
- W1990653227 modified "2023-10-10" @default.
- W1990653227 title "Histopathologic findings in patients with idiopathic megacolon: a comparison between dilated and non-dilated loops" @default.
- W1990653227 cites W1496736712 @default.
- W1990653227 cites W1586308643 @default.
- W1990653227 cites W1941718541 @default.
- W1990653227 cites W1966186927 @default.
- W1990653227 cites W1967991944 @default.
- W1990653227 cites W1968487793 @default.
- W1990653227 cites W1969087066 @default.
- W1990653227 cites W1980430887 @default.
- W1990653227 cites W1982684695 @default.
- W1990653227 cites W2011814583 @default.
- W1990653227 cites W2017702978 @default.
- W1990653227 cites W2019516277 @default.
- W1990653227 cites W2019788610 @default.
- W1990653227 cites W2027636000 @default.
- W1990653227 cites W2036749948 @default.
- W1990653227 cites W2038712529 @default.
- W1990653227 cites W2040266408 @default.
- W1990653227 cites W2058400264 @default.
- W1990653227 cites W2059782366 @default.
- W1990653227 cites W2064137248 @default.
- W1990653227 cites W2066900142 @default.
- W1990653227 cites W2073145300 @default.
- W1990653227 cites W2083626693 @default.
- W1990653227 cites W2086781269 @default.
- W1990653227 cites W2094562172 @default.
- W1990653227 cites W2101816766 @default.
- W1990653227 cites W2110367384 @default.
- W1990653227 cites W2112560918 @default.
- W1990653227 cites W2118329435 @default.
- W1990653227 cites W2120886811 @default.
- W1990653227 cites W2127557160 @default.
- W1990653227 cites W2136628620 @default.
- W1990653227 cites W2160232350 @default.
- W1990653227 cites W2162836422 @default.
- W1990653227 cites W2166167540 @default.
- W1990653227 cites W2171748785 @default.
- W1990653227 cites W2269706603 @default.
- W1990653227 cites W2324912146 @default.
- W1990653227 doi "https://doi.org/10.1111/nmo.12303" @default.
- W1990653227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24387755" @default.
- W1990653227 hasPublicationYear "2014" @default.
- W1990653227 type Work @default.
- W1990653227 sameAs 1990653227 @default.
- W1990653227 citedByCount "12" @default.
- W1990653227 countsByYear W19906532272015 @default.
- W1990653227 countsByYear W19906532272016 @default.
- W1990653227 countsByYear W19906532272017 @default.
- W1990653227 countsByYear W19906532272018 @default.
- W1990653227 countsByYear W19906532272019 @default.
- W1990653227 countsByYear W19906532272021 @default.
- W1990653227 countsByYear W19906532272022 @default.
- W1990653227 countsByYear W19906532272023 @default.
- W1990653227 crossrefType "journal-article" @default.
- W1990653227 hasAuthorship W1990653227A5002514925 @default.
- W1990653227 hasAuthorship W1990653227A5008918211 @default.
- W1990653227 hasAuthorship W1990653227A5031629829 @default.
- W1990653227 hasAuthorship W1990653227A5036068231 @default.
- W1990653227 hasAuthorship W1990653227A5043593857 @default.
- W1990653227 hasAuthorship W1990653227A5062001972 @default.
- W1990653227 hasAuthorship W1990653227A5083345625 @default.
- W1990653227 hasConcept C126322002 @default.
- W1990653227 hasConcept C142724271 @default.
- W1990653227 hasConcept C2776383484 @default.
- W1990653227 hasConcept C2777300911 @default.
- W1990653227 hasConcept C2778198053 @default.
- W1990653227 hasConcept C2779222388 @default.
- W1990653227 hasConcept C71924100 @default.
- W1990653227 hasConcept C90924648 @default.
- W1990653227 hasConceptScore W1990653227C126322002 @default.
- W1990653227 hasConceptScore W1990653227C142724271 @default.
- W1990653227 hasConceptScore W1990653227C2776383484 @default.
- W1990653227 hasConceptScore W1990653227C2777300911 @default.
- W1990653227 hasConceptScore W1990653227C2778198053 @default.
- W1990653227 hasConceptScore W1990653227C2779222388 @default.
- W1990653227 hasConceptScore W1990653227C71924100 @default.
- W1990653227 hasConceptScore W1990653227C90924648 @default.
- W1990653227 hasIssue "4" @default.
- W1990653227 hasLocation W19906532271 @default.
- W1990653227 hasLocation W19906532272 @default.
- W1990653227 hasOpenAccess W1990653227 @default.
- W1990653227 hasPrimaryLocation W19906532271 @default.
- W1990653227 hasRelatedWork W1995166202 @default.
- W1990653227 hasRelatedWork W2028305954 @default.
- W1990653227 hasRelatedWork W2082067523 @default.
- W1990653227 hasRelatedWork W2171285198 @default.
- W1990653227 hasRelatedWork W2319905926 @default.