Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990654868> ?p ?o ?g. }
- W1990654868 endingPage "813" @default.
- W1990654868 startingPage "801" @default.
- W1990654868 abstract "Motor neurons stimulate their postsynaptic muscle targets to synthesize neurotransmitter receptors. Polypeptide signaling molecules may mediate this inductive interaction. Here we report the purification of ARIA, a protein that stimulates the synthesis of muscle acetylcholine receptors, and the isolation of ARIA cDNA. Recombinant ARIA increases acetylcholine receptor synthesis greater than 3-fold, and it induces tyrosine phosphorylation of a 185 kd muscle protein. The ARIA cDNA hybridizes with mRNAs that are expressed in the spinal cord from E4, a time prior to the onset of neuromuscular synapse formation, through adulthood. By E7, hybridizing mRNAs are concentrated in motor neurons. Chicken ARIA is homologous to the rat Neu differentiation factor and human here-gulin, ligands for the receptor tyrosine kinase encoded by the neu (c-erbB2, HER2) proto-oncogene. Our data suggest that members of the ARIA protein family promote the formation and maintenance of chemical synapses and, furthermore, that receptor tyrosine kinases play important roles in this process." @default.
- W1990654868 created "2016-06-24" @default.
- W1990654868 creator A5019383777 @default.
- W1990654868 creator A5039163206 @default.
- W1990654868 creator A5055736230 @default.
- W1990654868 creator A5068019067 @default.
- W1990654868 creator A5083766083 @default.
- W1990654868 date "1993-03-12" @default.
- W1990654868 modified "2023-10-10" @default.
- W1990654868 title "ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family" @default.
- W1990654868 cites W1482931163 @default.
- W1990654868 cites W1596261235 @default.
- W1990654868 cites W1821999689 @default.
- W1990654868 cites W1918468642 @default.
- W1990654868 cites W1947994527 @default.
- W1990654868 cites W1965983162 @default.
- W1990654868 cites W1968739606 @default.
- W1990654868 cites W1972215155 @default.
- W1990654868 cites W1973188134 @default.
- W1990654868 cites W1985876982 @default.
- W1990654868 cites W1987872994 @default.
- W1990654868 cites W1990907625 @default.
- W1990654868 cites W1997551871 @default.
- W1990654868 cites W2006298249 @default.
- W1990654868 cites W2006874202 @default.
- W1990654868 cites W2014669590 @default.
- W1990654868 cites W2028387622 @default.
- W1990654868 cites W2030047847 @default.
- W1990654868 cites W2033367680 @default.
- W1990654868 cites W2037010084 @default.
- W1990654868 cites W2037475199 @default.
- W1990654868 cites W2039427822 @default.
- W1990654868 cites W2047559880 @default.
- W1990654868 cites W2047776262 @default.
- W1990654868 cites W2055043387 @default.
- W1990654868 cites W2058831382 @default.
- W1990654868 cites W2064641995 @default.
- W1990654868 cites W2066479669 @default.
- W1990654868 cites W2076631147 @default.
- W1990654868 cites W2077742489 @default.
- W1990654868 cites W2078183253 @default.
- W1990654868 cites W2078516754 @default.
- W1990654868 cites W2078831354 @default.
- W1990654868 cites W2079294363 @default.
- W1990654868 cites W2084548343 @default.
- W1990654868 cites W2088167128 @default.
- W1990654868 cites W2091156745 @default.
- W1990654868 cites W2092683047 @default.
- W1990654868 cites W2099703541 @default.
- W1990654868 cites W2128550942 @default.
- W1990654868 cites W2134812217 @default.
- W1990654868 cites W2159052209 @default.
- W1990654868 cites W2159287109 @default.
- W1990654868 cites W2159363679 @default.
- W1990654868 cites W2168643758 @default.
- W1990654868 cites W2226570905 @default.
- W1990654868 cites W2322962871 @default.
- W1990654868 cites W2401349306 @default.
- W1990654868 cites W2410558537 @default.
- W1990654868 cites W4211131955 @default.
- W1990654868 cites W55784314 @default.
- W1990654868 cites W96498672 @default.
- W1990654868 doi "https://doi.org/10.1016/0092-8674(93)90407-h" @default.
- W1990654868 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8453670" @default.
- W1990654868 hasPublicationYear "1993" @default.
- W1990654868 type Work @default.
- W1990654868 sameAs 1990654868 @default.
- W1990654868 citedByCount "593" @default.
- W1990654868 countsByYear W19906548682012 @default.
- W1990654868 countsByYear W19906548682013 @default.
- W1990654868 countsByYear W19906548682014 @default.
- W1990654868 countsByYear W19906548682015 @default.
- W1990654868 countsByYear W19906548682016 @default.
- W1990654868 countsByYear W19906548682017 @default.
- W1990654868 countsByYear W19906548682018 @default.
- W1990654868 countsByYear W19906548682019 @default.
- W1990654868 countsByYear W19906548682020 @default.
- W1990654868 countsByYear W19906548682021 @default.
- W1990654868 countsByYear W19906548682022 @default.
- W1990654868 countsByYear W19906548682023 @default.
- W1990654868 crossrefType "journal-article" @default.
- W1990654868 hasAuthorship W1990654868A5019383777 @default.
- W1990654868 hasAuthorship W1990654868A5039163206 @default.
- W1990654868 hasAuthorship W1990654868A5055736230 @default.
- W1990654868 hasAuthorship W1990654868A5068019067 @default.
- W1990654868 hasAuthorship W1990654868A5083766083 @default.
- W1990654868 hasConcept C101544691 @default.
- W1990654868 hasConcept C11960822 @default.
- W1990654868 hasConcept C153911025 @default.
- W1990654868 hasConcept C170493617 @default.
- W1990654868 hasConcept C197341189 @default.
- W1990654868 hasConcept C2911166042 @default.
- W1990654868 hasConcept C42362537 @default.
- W1990654868 hasConcept C55493867 @default.
- W1990654868 hasConcept C62478195 @default.
- W1990654868 hasConcept C80161118 @default.
- W1990654868 hasConcept C86803240 @default.
- W1990654868 hasConcept C95444343 @default.