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- W1990657629 abstract "Because AT/RT is a disease of early infancy associated with grim prognosis, very little attention has been placed to date on long term outcome, especially neurocognitive outcome. With the new era of multimodality therapy, some patients are now long term survivors. We reviewed our institutional experience of such patients to describe their neurocognitive status. From the 24 patients diagnosed between 1995 and 2010, 7 were long term survivors and 6 had at least one neurocognitive evaluation. Median age at diagnosis was 28 months (range 11.2-43.3). Three tumors were infratentorial. Four patients underwent a GTR and 2 were metastatic. All patients received postoperative high dose chemotherapy (3 cycles of CB/Thiotepa). Five patients received intrathecal chemotherapy. Only one patient received radiation (focal). Median age at time of neurocognitive assessment was 7.1 years (3.3-9.2). Full Scale Intellectual Quotient (FSIQ) ranged from 60 to 119 (median=71). Simple expressive and receptive language appeared relatively preserved (low average to superior). Two most recently diagnosed (2009-2010) patients assessed at 1.6 and 2.6 years from diagnosis presented with average to high average scores for FSIQ, academic and visual spatial skills, visual and verbal memory. Four other diagnosed earlier (2004, 2005, 2007) tested at a median time of 5 years (3.3-8.3) post-diagnosis had a FSIQ ranging from 60 to 71(median=68). Approximately 50% of their scores were in the impaired range. Whether these findings suggest further decline overtime or reflect an improvement in overall management of the recently diagnosed patients remain unclear. Nevertheless this cohort of infants appears significantly impaired at school age despite the absence of systematic radiotherapy. Larger series focusing on neurocognition are definitely needed before embracing adjuvant radiotherapy as a standard of care." @default.
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- W1990657629 date "2014-09-01" @default.
- W1990657629 modified "2023-10-03" @default.
- W1990657629 title "Neurocognitive Evaluation of Long Term Survivor’s Patients with AT/RT" @default.
- W1990657629 doi "https://doi.org/10.1016/j.cancergen.2014.09.033" @default.
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