Matches in SemOpenAlex for { <https://semopenalex.org/work/W1990657636> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W1990657636 endingPage "1936" @default.
- W1990657636 startingPage "1930" @default.
- W1990657636 abstract "Coronary artery disease is a significant risk factor for atrial fibrillation (AF), but the basis for this association is incompletely understood. The present study evaluated the hypothesis that atrial ischemia can create a substrate for AF maintenance.Atrial ischemia was induced by occlusion of an atrial arterial branch that did not provide blood flow to the ventricles. Atrial-arterial occlusion increased the duration of AF induced by burst pacing from 57+/-32 seconds (control) to 803+/-214 seconds (P<0.001) after 0.5 hour of occlusion and to 887+/-209 seconds (P<0.001) after 3 hours of occlusion. Prolonged AF (>20 minutes) was induced in 0 of 16 dogs (0%) under control conditions, 7 of 16 (44%, P<0.01) at 0.5 to 3 hours, and 5 of 13 (38%, P<0.01) 3 to 5 hours after occlusion. Atrial conduction was slowed substantially within the ischemic zone: eg, conduction delay was 8+/-1 ms at a cycle length of 200 ms, control, versus 22+/-5 ms (P<0.01) after 0.5 hours and 27+/-5 ms (P<0.001) after 3 hours of ischemia. Refractoriness was initially unaffected but was prolonged 5 hours after occlusion. Phase-delay analysis and high-density mapping confirmed severe conduction slowing in the ischemic zone. Histological examination confirmed the location of ischemic regions and revealed extensive ischemia-induced necrosis at sites of conduction delay.Experimental atrial ischemia creates a substrate for AF maintenance, apparently by causing local conduction slowing that promotes reentry. These results suggest that atrial ischemia may significantly promote AF, and may be relevant to AF mechanisms in association with coronary artery disease." @default.
- W1990657636 created "2016-06-24" @default.
- W1990657636 creator A5012446612 @default.
- W1990657636 creator A5054206623 @default.
- W1990657636 creator A5064311226 @default.
- W1990657636 creator A5070066663 @default.
- W1990657636 creator A5075088707 @default.
- W1990657636 creator A5075171303 @default.
- W1990657636 date "2003-04-15" @default.
- W1990657636 modified "2023-10-04" @default.
- W1990657636 title "Atrial Ischemia Promotes Atrial Fibrillation in Dogs" @default.
- W1990657636 cites W1976123882 @default.
- W1990657636 cites W1983902228 @default.
- W1990657636 cites W2011966416 @default.
- W1990657636 cites W2014394690 @default.
- W1990657636 cites W2018173278 @default.
- W1990657636 cites W2062206620 @default.
- W1990657636 cites W2088444802 @default.
- W1990657636 cites W2088742606 @default.
- W1990657636 cites W2094455991 @default.
- W1990657636 cites W2096382911 @default.
- W1990657636 cites W2098355201 @default.
- W1990657636 cites W2106992623 @default.
- W1990657636 cites W2132337019 @default.
- W1990657636 cites W2149166027 @default.
- W1990657636 cites W2153144629 @default.
- W1990657636 doi "https://doi.org/10.1161/01.cir.0000058743.15215.03" @default.
- W1990657636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12668526" @default.
- W1990657636 hasPublicationYear "2003" @default.
- W1990657636 type Work @default.
- W1990657636 sameAs 1990657636 @default.
- W1990657636 citedByCount "226" @default.
- W1990657636 countsByYear W19906576362012 @default.
- W1990657636 countsByYear W19906576362013 @default.
- W1990657636 countsByYear W19906576362014 @default.
- W1990657636 countsByYear W19906576362015 @default.
- W1990657636 countsByYear W19906576362016 @default.
- W1990657636 countsByYear W19906576362017 @default.
- W1990657636 countsByYear W19906576362018 @default.
- W1990657636 countsByYear W19906576362019 @default.
- W1990657636 countsByYear W19906576362020 @default.
- W1990657636 countsByYear W19906576362021 @default.
- W1990657636 countsByYear W19906576362022 @default.
- W1990657636 countsByYear W19906576362023 @default.
- W1990657636 crossrefType "journal-article" @default.
- W1990657636 hasAuthorship W1990657636A5012446612 @default.
- W1990657636 hasAuthorship W1990657636A5054206623 @default.
- W1990657636 hasAuthorship W1990657636A5064311226 @default.
- W1990657636 hasAuthorship W1990657636A5070066663 @default.
- W1990657636 hasAuthorship W1990657636A5075088707 @default.
- W1990657636 hasAuthorship W1990657636A5075171303 @default.
- W1990657636 hasBestOaLocation W19906576361 @default.
- W1990657636 hasConcept C114021368 @default.
- W1990657636 hasConcept C126322002 @default.
- W1990657636 hasConcept C164705383 @default.
- W1990657636 hasConcept C2776268601 @default.
- W1990657636 hasConcept C2777720157 @default.
- W1990657636 hasConcept C2779161974 @default.
- W1990657636 hasConcept C2780393670 @default.
- W1990657636 hasConcept C42219234 @default.
- W1990657636 hasConcept C541997718 @default.
- W1990657636 hasConcept C70616116 @default.
- W1990657636 hasConcept C71924100 @default.
- W1990657636 hasConceptScore W1990657636C114021368 @default.
- W1990657636 hasConceptScore W1990657636C126322002 @default.
- W1990657636 hasConceptScore W1990657636C164705383 @default.
- W1990657636 hasConceptScore W1990657636C2776268601 @default.
- W1990657636 hasConceptScore W1990657636C2777720157 @default.
- W1990657636 hasConceptScore W1990657636C2779161974 @default.
- W1990657636 hasConceptScore W1990657636C2780393670 @default.
- W1990657636 hasConceptScore W1990657636C42219234 @default.
- W1990657636 hasConceptScore W1990657636C541997718 @default.
- W1990657636 hasConceptScore W1990657636C70616116 @default.
- W1990657636 hasConceptScore W1990657636C71924100 @default.
- W1990657636 hasIssue "14" @default.
- W1990657636 hasLocation W19906576361 @default.
- W1990657636 hasLocation W19906576362 @default.
- W1990657636 hasLocation W19906576363 @default.
- W1990657636 hasOpenAccess W1990657636 @default.
- W1990657636 hasPrimaryLocation W19906576361 @default.
- W1990657636 hasRelatedWork W167357359 @default.
- W1990657636 hasRelatedWork W1990657636 @default.
- W1990657636 hasRelatedWork W1994993426 @default.
- W1990657636 hasRelatedWork W1997914936 @default.
- W1990657636 hasRelatedWork W2129995238 @default.
- W1990657636 hasRelatedWork W2168924687 @default.
- W1990657636 hasRelatedWork W2406175927 @default.
- W1990657636 hasRelatedWork W2410701524 @default.
- W1990657636 hasRelatedWork W2413547361 @default.
- W1990657636 hasRelatedWork W2417545851 @default.
- W1990657636 hasVolume "107" @default.
- W1990657636 isParatext "false" @default.
- W1990657636 isRetracted "false" @default.
- W1990657636 magId "1990657636" @default.
- W1990657636 workType "article" @default.